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Shravankumar Kankala Niranjan Thota Fredrik Björkling Myles K. Taylor Ravinder Vadde Ramesh Balusu 《Drug development research》2019,80(2):188-199
Cancer is a major global health problem with large therapeutic challenges. Although substantial progress has been made in cancer therapy, there still remains a need to develop novel and effective treatment strategies to treat several relapsed and refractory cancers. Recently, there has been growing demand for considering organometallics as antineoplastic agents. This review is focused on a group of organometallics, silver N-heterocyclic carbene complexes (SCCs) and their anticancer efficacy in targeting multiple pathways in various in vitro cancer model systems. However, the precise molecular mechanism of SCCs anticancer properties remains unclear. Here, we discuss the SCCs chemistry, potential molecular targets, possible molecular mechanism of action, and their application in cancer therapies. 相似文献
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D. Kishorkumar P. Stalin R. Vishnu Prasad Zile Singh J. P. Tripathy A. Sharma S. Prinja Vijay Gupta Victoria Job Niranjan Thomas Nalinikant Panigrahy Poddutoor Preetham Kumar Dinesh Kumar Chirla Shivanarayan Reddy Vennapusa M. Noll P. R. S. Noll E. M. Santos A. R. Silva Neto C. T. Candotti Pankaj Kumar Mohanty Karthik Nagesh N Abdul Razak 《Indian pediatrics》2016,53(2):165-172
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Novel cardiovascular magnetic resonance oxygenation approaches in understanding pathophysiology of cardiac diseases 下载免费PDF全文
Karthigesh Sree Raman Gaetano Nucifora Joseph B Selvanayagam 《Clinical and experimental pharmacology & physiology》2018,45(5):475-480
Cardiovascular magnetic resonance imaging (CMR) permits accurate phenotyping of many cardiac diseases. CMR’s inherent advantages are its non‐invasive nature, lack of ionizing radiation and high accuracy and reproducibility. Furthermore, it is able to assess many aspects of cardiac anatomy, structure and function. Specifically, it can characterize myocardial tissue, myocardial function, myocardial mass, myocardial blood flow/perfusion, irreversible and reversible injury, all with a high degree of accuracy and reproducibility. Hence, CMR is a powerful tool in clinical and pre‐clinical research. In recent years there have been novel advances in CMR myocardial tissue characterization. Oxygenation‐sensitive CMR (OS‐CMR) is a novel non‐invasive, contrast independent technique that permits direct quantification of myocardial tissue oxygenation, both at rest and during stress. In this review, we will address the principles of the OS‐CMR technique, its recent advances and summarize the studies in the effects of oxygenation on cardiac diseases. 相似文献
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Chehaibou Ismael Manoharan Niranjan Govetto Andrea Francone Anibal Andrés Sarraf David Hubschman Jean-Pierre 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(12):2611-2619
Graefe's Archive for Clinical and Experimental Ophthalmology - To evaluate and compare the rate and characteristics of vitreoretinal disorders in fellow eyes of lamellar macular holes (LMH)... 相似文献
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Timothy W. Farrell MD AGSF Leslie Francis PhD JD Teneille Brown JD Lauren E. Ferrante MD MHS Eric Widera MD Ramona Rhodes MD MPH MSCS AGSF Tony Rosen MD MPH Ula Hwang MD MPH Leah J. Witt MD Niranjan Thothala MD MRCP MBA Shan W. Liu MD SD Caroline A. Vitale MD AGSF Ursula K. Braun MD MPH Caroline Stephens PhD RN GNP-BC Debra Saliba MD MPH AGSF 《Journal of the American Geriatrics Society》2020,68(6):1143-1149
Coronavirus disease 2019 (COVID-19) continues to impact older adults disproportionately with respect to serious consequences ranging from severe illness and hospitalization to increased mortality risk. Concurrently, concerns about potential shortages of healthcare professionals and health supplies to address these issues have focused attention on how these resources are ultimately allocated and used. Some strategies, for example, misguidedly use age as an arbitrary criterion that disfavors older adults in resource allocation decisions. This is a companion article to the American Geriatrics Society (AGS) position statement, “Resource Allocation Strategies and Age-Related Considerations in the COVID-19 Era and Beyond.” It is intended to inform stakeholders including hospitals, health systems, and policymakers about ethical considerations that should be considered when developing strategies for allocation of scarce resources during an emergency involving older adults. This review presents the legal and ethical background for the position statement and discusses these issues that informed the development of the AGS positions: (1) age as a determining factor, (2) age as a tiebreaker, (3) criteria with a differential impact on older adults, (4) individual choices and advance directives, (5) racial/ethnic disparities and resource allocation, and (6) scoring systems and their impact on older adults. It also considers the role of advance directives as expressions of individual preferences in pandemics. J Am Geriatr Soc 68:1143–1149, 2020. 相似文献
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Jian Yan Daniel O. Villarreal Trina Racine Jaemi S. Chu Jewell N. Walters Matthew P. Morrow Amir S. Khan Niranjan Y. Sardesai J. Joseph Kim Gary P. Kobinger David B. Weiner 《Vaccine》2014
Despite an intensive vaccine program influenza infections remain a major health problem, due to the viruses’ ability to change its envelope glycoprotein hemagglutinin (HA), through shift and drift, permitting influenza to escape protection induced by current vaccines or natural immunity. Recently a new variant, H7N9, has emerged in China causing global concern. First, there have been more than 130 laboratory-confirmed human infections resulting in an alarmingly high death rate (32.3%). Second, genetic changes found in H7N9 appear to be associated with enabling avian influenza viruses to spread more effectively in mammals, thus transmitting infections on a larger scale. Currently, no vaccines or drugs are effectively able to target H7N9. Here, we report the rapid development of a synthetic consensus DNA vaccine (pH7HA) to elicit potent protective immunity against the H7N9 viruses. We show that pH7HA induces broad antibody responses that bind to divergent HAs from multiple new members of the H7N9 family. These antibody responses result in high-titer HAI against H7N9. Simultaneously, this vaccine induces potent polyfunctional effector CD4 and CD8T cell memory responses. Animals vaccinated with pH7HA are completely protected from H7N9 virus infection and any morbidity associated with lethal challenge. This study establishes that this synthetic consensus DNA vaccine represents a new tool for targeting emerging infection, and more importantly, its design, testing and development into seed stock for vaccine production in a few days in the pandemic setting has significant implications for the rapid deployment of vaccines protecting against emerging infectious diseases. 相似文献