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991.
Buprenorphine is a mixed opioid agonist/antagonist analgesic. This study was designed to determine the role of opioid receptor subtypes, especially κ3, in buprenorphine-induced analgesia in mice. Buprenorphine, when injected systemically, revealed a potent analgesic effect by tailflick assay, with a biphasic dose–response curve, which was reversed by naloxone. The presence of analgesic cross-tolerance between buprenorphine and naloxone benzoylhydrazone (NalBzoH) and morphine indicated a role for κ3 and μ receptor subtype in buprenorphine analgesia. Additional studies with selective opioid antagonists indicated κ1 mechanisms of action. We did not detect any involvement of the δ receptor subtype. Low doses of buprenorphine antagonized morphine analgesia, while high doses of buprenorphine coadministered with morphine elicited increasing analgesia in a dose-dependent manner. These findings suggest that buprenorphine elicits analgesia through an interaction with κ3 receptors and to a lesser extent with κ1 as well as its activity as partial μ receptor agonist. 相似文献
992.
G. Brix W. Schreiber U. Hoffmann F. Gückel H. Hawighorst M. V. Knopp 《Der Radiologe》1997,37(6):470-480
Summary
The development of rapid magnetic resonance imaging (MRI) sequences makes it possible to detect the fast kinetics of tissue
response after intraveneous administration of paramagnetic contrast media (CM), reflecting the status of tissue microcirculation.
In this paper, the basic physical and tracer kinetic principles of dynamic relaxivity and susceptibility contrast MRI techniques
are reviewed. The quantitative analysis of the acquired dynamic image data is broken up into an MR specific part, in which
the observed signal variations are related to the CM concentration in the tissue, and an MR independent part, in which the
computed concentration-time-courses are analyzed by tracer kinetic modeling. The purpose of the applied models is to describe
the underlying physiological processes in mathematical terms and thus to enable the estimation of tissue specific parameters
from measured dynamic image series. Whereas the capillary permeability can be estimated from dynamic relaxivity contrast enhanced
MRI studies, the regional blood volume as well as the regional blood flow can be determined from dynamic susceptibility contrast
enhanced image series. However, since there are no intravascular but only diffusible CM available at present, the application
of the susceptibility technique is currently restricted to brain tissues with intact blood brain barrier. The practical realization
of both dynamic MRI techniques is demonstrated by case studies.
Eingegangen am 5. M?rz 1997 Angenommen am 24. April 1997 相似文献
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R Hehlmann V Erfle H Schetters A Luz H Rohmer M A Schreiber H Pralle U Essers W Weber 《Cancer》1984,54(12):2927-2935
Human sera contain antigens and also circulating immune complexes that are related to the primate retroviral envelope glycoprotein gp70 of simian sarcoma/simian sarcoma associated virus (SiSV) and of gibbon ape leukemia virus (GaLV). SiSVgp70 related antigens (AG) and immune complexes (IC) are detected both in leukemic and in nonleukemic sera. In a further analysis of these data, the prognostic significance of SiSVgp70 related AG and IC in leukemic patients was examined. The data show that the presence of SiSVgp70 related AG and IC indicates an unfavorable clinical course and a shorter survival time in acute leukemias (AL) and in chronic myelogenous leukemia in blast crisis (CML-BC). Survival data of 56 of 64 patients tested were analyzed (38 patients with AL and 18 patients with CML-BC). Patients with AL whose sera were positive for SiSVgp70 related AG and IC had a median survival time of 9.5 months after diagnosis versus 16 months for patients negative for such AG and IC. This difference in survival time was more pronounced for patients with acute nonlymphocytic leukemia (ANLL) (6.5 versus 19 months). The difference in survival between SiSVgp70 related AG- and IC-negative and positive groups as tested by life table analysis (log-rank test) is significant (P less than 0.05). Patients with AL of the AG- and/or IC-positive group had fewer complete remissions. Patients who had no remissions belong to the AG- and/or IC-positive group (P = 0.06). Patients with CML-BC whose sera were positive for SiSVgp70 related AG and/or IC had a median survival time of 2 months after diagnosis versus 7 months for patients with sera negative for such AG and IC. As tested by log-rank test, survival curves between the two groups are significantly different (P less than 0.05). These findings suggest that SiSVgp70 related AG and IC may play an important role in the course of acute leukemia and can provide useful prognostic information. 相似文献
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F Schreiber G Brandst?tter H Pristautz H Wenzl H Savli M Kronawetter 《Zeitschrift für Gastroenterologie》1991,29(9):429-432
A huge common bile duct stone of 6 to 3 cm in diameter in a 64 year old lady was approached by ESWL, after endoscopic therapy such as mechanical lithotripsy and removal with the Dormia basket had failed because of the extraordinary size of this stone. A surgical therapy was not possible because of pronounced vascular and cardiopulmonary risk, so ESWL was applied to this patient. The stone was fragmented in two sessions of ESWL under sonographic targeting and the fragments were removed endoscopically. After one month one fragment still remained in the common bile duct, which then was removed also endoscopically. Two months later the ERC showed a stone-free common bile duct. This case demonstrates, that even common bile duct stones of extraordinary size can be removed by combining ESWL with endoscopic techniques. Following the trend to minimally invasive therapy, sonography should be preferred over XRay in diagnosis before ESWL as well as during ESWL. 相似文献
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