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排序方式: 共有425条查询结果,搜索用时 46 毫秒
71.
Adamzik M Langemeier T Frey UH Görlinger K Saner F Eggebrecht H Peters J Hartmann M 《Shock (Augusta, Ga.)》2011,35(4):339-342
Disseminated intravascular coagulation contributes to mortality of sepsis. The study was performed to investigate thromboelastometry as a potential predictor of 30-day survival in severe sepsis and to compare thromboelastometry to Simplified Acute Physiology Score II (SAPS II) and Sequential Organ Failure Assessment (SOFA) scores. Ninety-eight patients with severe sepsis were included in the cohort study. Thromboelastometry clotting time, clot formation time (CFT), maximum clot firmness (MCF), and α angle as well as SAPS II and SOFA scores were determined at the day of diagnosis. Thromboelastometry variables differed in survivors and nonsurvivors. Mean CFT was prolonged (276 ± 194 vs. 194 ± 109 s, P = 0.021; mean ± SD), and both MCF (52.7 ± 12.1 mm vs. 57.3 ± 11.5 mm, P = 0.042) and α angle (53.4 ± 12.8 degrees vs. 58.9 ± 11.8 degrees, P = 0.028) were reduced in nonsurvivors. Clotting time and SAPS II and SOFA scores were not different. Thromboelastometry values were classified as normal and pathological, respectively, using the median of the variables as the cutoff. Thromboelastometry values were normal if CFT was less than 185 s, MCF was greater than 55 mm, and α was greater than 57.5 degrees. Thirty-day survival was 85.7% when all thromboelastometry variables were normal, but 58.7% when at least one variable was pathological (P = 0.005). Multivariate analysis revealed that the absence or presence of at least one pathological thromboelastometry variable allows for better prediction of 30-day survival in severe sepsis than the SAPS II and SOFA scores (P = 0.01; odds ratio, 4.1), respectively, emphasizing the importance of the coagulation system in sepsis. 相似文献
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Roland von Känel Chiara C. Abbas Hugo Saner Monika Stutz 《Journal of psychiatric research》2010,44(14):956-963
Hypercoagulability of the blood might partially explain the increased cardiovascular disease risk in posttraumatic stress disorder (PTSD) and is also triggered by anticipatory stress. We hypothesized exaggerated procoagulant reactivity in patients with PTSD in response to a trauma-specific interview that would be moderated by momentary stress levels. We examined 23 patients with interviewer-diagnosed PTSD caused by myocardial infarction (MI) and 21 post-MI patients without PTSD. A second diagnostic (i.e., trauma-specific) interview to assess posttraumatic stress severity was performed after a median follow-up of 26 months (range 12-36). Before that interview patients rated levels of momentary stress (Likert scale 0-10) and had blood collected before and after the interview. The interaction between PTSD diagnostic status at study entry and level of momentary stress before the follow-up interview predicted reactivity of fibrinogen (P = 0.036) and d-dimer (P = 0.002) to the PTSD interview. Among patients with high momentary stress levels, PTSD patients had greater fibrinogen (P = 0.023) and d-dimer (P = 0.035) reactivity than non-PTSD patients. Among patients with low momentary stress levels, PTSD patients had less d-dimer reactivity than non-PTSD patients (P = 0.024); fibrinogen reactivity did not significantly differ between groups. Momentary stress levels, but not severity of posttraumatic stress, correlated with d-dimer reactivity in PTSD patients (r = 0.46, P = 0.029). We conclude that momentary stress levels moderated the relationship between PTSD and procoagulant reactivity to a trauma-specific interview. Procoagulant reactivity in post-MI patients with PTSD confronted with their traumatically experienced MI was observed if patients perceived high levels of momentary stress before the interview. 相似文献
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Kirsten M van Steenbergen-Weijenburg Lars de Vroege Robert R Ploeger Jan W Brals Martijn G Vloedbeld Thiemo F Veneman Leona Hakkaart-van Roijen Frans FH Rutten Aartjan TF Beekman Christina M van der Feltz-Cornelis 《BMC health services research》2010,10(1):235
Background
For the treatment of depression in diabetes patients, it is important that depression is recognized at an early stage. A screening method for depression is the patient health questionnaire (PHQ-9). The aim of this study is to validate the 9-item Patient Health Questionnaire (PHQ-9) as a screening instrument for depression in diabetes patients in outpatient clinics. 相似文献78.
Saner F Gu Y Minouchehr S Ilker K Fruhauf NR Paul A Radtke A Dammann M Katsarava Z Koeppen S Malagó M Broelsch CE 《Journal of neurology》2006,253(5):612-617
Problems related to
the central nervous system have a
major impact on survival and
quality of life. The aim of this
retrospective study was to evaluate
the incidence of neurological complications
after liver transplantation (LT), including both cadaveric
and living donor liver transplantation.
Between April 2001 and
March 2004 174 patients (120 cadaveric
liver transplantations, 54
living donor transplantations) were
admitted to our intensive care after
liver transplantation. Of the transplanted
patients 24.7% developed
neurological complications. These
patients’ stay in the intensive care
(14.2 ± 17.2 days) was much longer
than that of all admitted patients
(8.4 ± 10.5 days, p < 0.05). The most
common neurological complications
were encephalopathy (72.1%)
and seizures (11.6 %). The incidence
of neurological complications
in living donor liver transplanted
patients was significantly
lower than in cadaveric transplantation
patients (20.4% vs
26.7 %). The cold ischemia time in
living donor transplanted patients
was significantly shorter in comparison
with cadaveric transplanted
patients (215 ± 119.3 vs.
383.7 ± 214.7). The survival rate
after liver transplantation of
patients with neurological complications
was lower than that of
patients without, but not significantly
different (79.1 % vs. 82.4%,
p > 0.05). The incidence of neurological
symptoms was found to be
similar between the patients
treated with cyclosporine (25%)
and tacrolimus (23.8 %) in this
study. In conclusion, there was a
high incidence of neurological
complications after LT, prolonging
the patients’ stay in intensive care
significantly. The major neurological
manifestation in our patients
was encephalopathy followed by
seizures. Living donor liver transplantation
was associated with a
significantly lower incidence of
neurological complications compared
with patients who had received
a cadaveric graft. This might
be due to the good quality of the
organ and the much shorter cold
ischemia time of the graft when the
donor was alive. 相似文献
79.
80.
目的测定甘肃产五加中剌五加苷B、苷E的含量。方法高效液相色谱法,ODSKromasal柱。水乙晴(955)为流动相,检测波长222nm,柱温度25℃。结果本文可同时测定剌五加苷B、苷E的含量。剌五加苷B、苷E分别在0.064~0.320μg/ml;0.074~0.370μg/ml范围内峰面积与浓度呈线性关系,平均回收率分别为102.5%,RSD=4.2%,95.5%,RSD=4.6%。结论剌五加苷B、苷E在红毛五加中含量最高;茎皮中含量最高;剌五加苷E的含量高于苷B。 相似文献