全文获取类型
收费全文 | 4539篇 |
免费 | 302篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 40篇 |
儿科学 | 138篇 |
妇产科学 | 61篇 |
基础医学 | 598篇 |
口腔科学 | 103篇 |
临床医学 | 287篇 |
内科学 | 1107篇 |
皮肤病学 | 124篇 |
神经病学 | 511篇 |
特种医学 | 105篇 |
外科学 | 727篇 |
综合类 | 13篇 |
预防医学 | 208篇 |
眼科学 | 73篇 |
药学 | 381篇 |
中国医学 | 20篇 |
肿瘤学 | 362篇 |
出版年
2023年 | 31篇 |
2022年 | 49篇 |
2021年 | 126篇 |
2020年 | 90篇 |
2019年 | 117篇 |
2018年 | 141篇 |
2017年 | 115篇 |
2016年 | 131篇 |
2015年 | 106篇 |
2014年 | 166篇 |
2013年 | 183篇 |
2012年 | 352篇 |
2011年 | 326篇 |
2010年 | 174篇 |
2009年 | 135篇 |
2008年 | 243篇 |
2007年 | 229篇 |
2006年 | 222篇 |
2005年 | 232篇 |
2004年 | 183篇 |
2003年 | 201篇 |
2002年 | 177篇 |
2001年 | 69篇 |
2000年 | 84篇 |
1999年 | 76篇 |
1998年 | 37篇 |
1997年 | 24篇 |
1996年 | 14篇 |
1995年 | 17篇 |
1994年 | 15篇 |
1993年 | 18篇 |
1992年 | 61篇 |
1991年 | 45篇 |
1990年 | 51篇 |
1989年 | 38篇 |
1988年 | 56篇 |
1987年 | 56篇 |
1986年 | 51篇 |
1985年 | 50篇 |
1984年 | 51篇 |
1983年 | 35篇 |
1979年 | 36篇 |
1978年 | 13篇 |
1977年 | 18篇 |
1974年 | 23篇 |
1973年 | 15篇 |
1971年 | 24篇 |
1970年 | 19篇 |
1968年 | 23篇 |
1966年 | 12篇 |
排序方式: 共有4858条查询结果,搜索用时 390 毫秒
81.
Izumi Mihashi Kazuhiro Ishii Yasuhiro Ogawa Ayako Uchida Hisato Hara Akira Tamaoka 《Internal medicine (Tokyo, Japan)》2021,60(6):953
We herein report a 39-year-old woman who had aggravated body pain, waddling gait, and fatigability for the past 2 years. A neurological examination showed hyperreflexia and proximal muscle weakness. The serum calcium level was normal (10.1 mg/dL). However, serum alkaline phosphatase (3,855 IU/I) and parathyroid hormone (1,008 pg/mL) levels were remarkably high. Cervical ultrasonography revealed parathyroid goiter. The patient was diagnosed with hyperparathyroidism. Her muscle weakness and pain improved within three months after parathyroidectomy. Our findings suggest that clinicians should consider hyperparathyroidism as a differential diagnosis in patients with proximal muscle weakness, even if the serum calcium level is normal. 相似文献
82.
83.
84.
Masami Taniguchi Naomi Tsurikisawa Noritaka Higashi Hiroshi Saito Haruhisa Mita Akio Mori Hiroki Sakakibara Kazuo Akiyama 《Allergology international》2007,56(2):97-103
Churg-Strauss syndrome (CSS) is characterized by the presence of asthma, eosinophilia, and small-vessel vasculitis with granuloma. It is a distinct entity, as determined from all classifications of systemic vasculitis. The poor prognostic factors in CSS are renal insufficiency, cardiomyopathy, severe gastrointestinal (GI) tract, and central nervous systems (CNS) involvement. The initial management of CSS should include a high dose of a corticosteroid: prednisone at 1 mg/kg/day or its equivalent for methylprednisolone with tapering over 6 months. In patients with severe or rapidly progressing CSS, the administration of methylprednisolone pulse at 1 g/body/day for 3 days is recommended. When corticosteroid therapy does not induce remission, or when patients have poor prognostic factors, immunosuppressive cytotoxic therapy is indicated. However, some patients with severe CSS often show resistance to conventional treatment. We think that IVIG therapy is a hopeful candidate for second-line treatment for CSS patients, particularly in the case of neuropathy and/or cardiomyopathy, which are resistant to conventional therapy. However, there is not much evidence supporting the effectiveness of IVIG in CSS, and the mechanisms underlying the action of IVIG remain unclear. Now we are performing clinical trials of IVIG therapy for CSS patients who are resistant to conventional treatment, through a nationwide double-blinded placebo-controlled study in Japan. 相似文献
85.
Masayoshi Yokoyama Atsushi Sakamoto Souji Konno Shigeru Sakakibara 《American heart journal》1974,87(1):15-20
Patients with mitral stenosis usually showed a marked increase in the P negativity following exercise. The P terminal force in Lead V1 in 20 cases with isolated mitral stenosis was ?0.090 mm. sec. before exercise, which changed to ?0.177 mm. sec. following the single Master two-step test.Normal adults never showed such changes on exercise. The phenomenon was considered to be due to the posterior rotation of the P wave vector in the horizontal plane, which was induced by the enlargement of the left atrial wall on exercise. 相似文献
86.
87.
Takeshi Igarashi Tatsuhiko Kurose Kouichi Itabashi Ikuo Nakano Kenzo Okamoto Ayako Sano Kiyonobu Kimura Hiroshi Kaji 《Nihon Kokyūki Gakkai zasshi》2004,42(7):629-633
In a 43-year-old Japanese Brazilian who came to Japan in 2001, since subjective symptoms such as cough, sputum, and dyspnea on exertion had become severe, he was referred to our hospital because of suspicion of pulmonary tuberculosis in chest radiography and CT findings. A chest radiograph of initial examination showed interstitial shadows in both lungs with nodular, infiltrative or cavitary changes. No Mycobacterium tuberculosis was found. The mycetocyte with multipolar budding resembling the steerage of a ship, which was characteristic of Paracoccidioides was observed in sputum and transbronchial lung biopsy specimens. We cultured a fungus to show dimorphism of temperature dependency, and a diagnosis of chronic lung paracoccidioidomycosis was arrived at. By administration of ITCZ 200 mg/day, the chest radiography findings and clinical manifestations were improved. This case seems to be worthy of reporting in Japan since the affected site or organ was limited to the two lungs with multiple cavitary lesions and fibrotic changes on radiographic examination, and final diagnosis was made by cytology of sputum and pathology of TBLB specimens. 相似文献
88.
89.
90.
Yasuhiro Chihara Ayako Sato Michiteru Ohtani Chisato Fujimoto Takahiro Hayashi Hironobu Nishijima Masato Yagi Shinichi Iwasaki 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2013,231(3):257-266
First-generation H1-antihistamines are known to cause fatigue and drowsiness, due to their poor receptor selectivity and their high penetration rate of the blood–brain barrier. However, little is known about the effects of first-generation H1-antihistamines on postural stability. The purpose of this study was to evaluate the effects of d-chlorpheniramine on postural stability using posturography with and without foam rubber. A double-blind study with three parallel groups was conducted. Twenty-seven healthy young volunteers (mean age 21.9 years) were recruited and orally administered d-chlorpheniramine, 2 or 4 mg, or placebo. Postural sway was measured every hour up to 8 h after administration. Two-legged stance tasks were performed by each subject in four conditions: eyes open or eyes closed and with or without foam rubber. Inter-group comparisons showed that the group receiving 4-mg d-chlorpheniramine showed significantly larger sway in the eyes open with foam rubber condition (visual and vestibular information available, somatosensory information reduced). Inter-subject analysis in the 4-mg d-chlorpheniramine group showed that the effect of d-chlorpheniramine on postural control was variable. Our results suggest that among the three main sensory systems responsible for postural control (visual, vestibular, and somatosensory), d-chlorpheniramine may have a larger effect on the visual and/or vestibular systems in susceptible individuals. 相似文献