门诊牙周病患者相关知识掌握和健康服务需求状况调查

目的 了解牙周病患者相关健康知识掌握情况和相关服务的需求状况,为开展牙周病健康教育提供依据。方法 采取随机抽样的方法 ,抽取304医院口腔门诊及第二炮兵设计研究院门诊部口腔科的牙周病患者进行相关知识掌握情况和对相关服务需求情况调查。结果 牙周病患者12.70%有治疗意识;对相关知识了解的占19.44%;不知道已经患牙周病的占51.59%;92.20%的人最希望从医生处获取健康知识,93.90%的患者认可健康教育讲座,78.40%的患者希望每年进行一次保健性质的口腔检查,40.00%的患者愿意成为会员制口腔诊所的会员。结论 牙周病患者掌握了一定的口腔健康知识,但对牙周病仍存在一定的盲区和误区,口腔科医务人员应该根据调查患者的知识掌握情况和实际需求开展健康教育和健康服务。     

伍用TRH与ICI174,864对兔失血性休克心功能的影响

采用脑室给药方法研究了促甲状腺素释放激素（ＴＲＨ）与δ－阿片受体特异性拮抗剂ＩＣＩ１７４，８６４合用对失血性休克兔心功能指标的影响，旨在探讨ＴＲＨ与ＩＣＩ１７４，８６４是否可配伍用药治疗休克。ＴＲＨ、ＩＣＩ１７４，８６４两药单用剂量各为５０μｇ，合用剂量各２５μｇ。结果显示，两药半量合用改善失血性休克兔心血管功能作用不仅可达单药５０μｇ的效果，且较单用效果更佳。表明两药可配伍用药治疗失血性休克，且有一定的协同作用。     

The Protein Expression of Bcl-2, Bax, Fas/Apo-1 in Acute Myeloid Leukemia

Homeostasisof11ematopoiesisiscontrollednotoillybytheproliferationanddifferentiationofcells,butalsobycelldeath.Inadditiontolossofcontrolofcellproliferation,disruptionofapoptosis--inducedf[lnctionalsocontributestotumordevelopment.Althoughdiversesignalscaninduceapoptosisinawidevarietyofcelltypes,anumberofevolutionarilyconservedgenesregulateafinalcommoncelldeathpathway,thatisconservedinmanyspeciesfromwormstohumansll].Thehcf--2proto--oncogeneisoneofthecrucialapoptosisantagonizinggenes.Highlevelofhc…     

双酚胺酸对小鼠和大鼠氯化镍解毒及分布的影响

AIM: To study the effect of catecholamic acid (CBMIDA) on detoxication of NiCl2. METHODS: Mice and rats were injected s.c. or i.m. CBMIDA immediately after i.p. NiCl2. Each mouse was injected i.p. CBMIDA after i.v. 63NiCl2 185 kBq, and radioactivities of various tissues were measured with liquid scintillation counter at 24 h. The localization of 63Ni was shown by the whole-body autoradiography. RESULTS: CBMIDA s.c. 0.5-1.5 g.kg-1 markedly reduced the mortality from acute poisoning of i.p. NiCl2 500 mg.kg-1. After i.p. NiCl2 in mice, the LD50 was 82.7 mg.kg-1. Mice were injected s.c. CBMIDA 1.5 or 2.5 g.kg-1 after Ni poisoning, the LD50 of NiCl2 were raised to 789 or 820 mg.kg-1, respectively. The LD50 of NiCl2 was 39 mg.kg-1 in rat. If CBMIDA was injected i.m. 0.5 g.kg-1 after i.p. NiCl2, the LD50 was 332 mg.kg-1. CBMIDA 1.5 g.kg-1 i.m. after i.v. 63NiCl2, decreased the contents of 63Ni in blood and lung of mice vs control mice at 24 h. The contents of 63Ni in brain, heart, spleen, and kidney were similar to those of the control mice. The content of 63Ni in bone was more than the control. The excretions of 63Ni through urine and feces were not increased by CBMIDA at 24 h. The whole-body autoradiography showed that the radioactivity was highly localized in the kidney, lung, and Harder's gland. There was a moderate level of 63Ni in the liver, bone, skin, and blood. A pronounced accumulation occurred in the bone. There was a marked reduction of 63Ni in the lung, skin, liver, and blood after i.p. CBMIDA. CONCLUSION: The CBMIDA markedly raised the survival rate of nickel-poisoned mice and rats, and decreased 63Ni levels in lung and blood.     

维生素E、C和B_2联用对小鼠血糠的影响

本实验研究用四氧嘧啶造成小鼠糖尿病模型，灌胃给予小鼠按一定比例配伍的维生素Ｅ、Ｃ、Ｂ_２，观察其对小鼠血糖水平的影响。结果显示，维生素Ｅ、Ｃ和Ｂ_２联用能有效地降低小鼠的高血糖，其血糖值（３５．５１±６．０２ｍｍｏｌ／Ｌ）明显低于四氧嘧啶组（５２．５８±８．０３ｍｍｏｌ／Ｌ），两者之间差异有显著性意义（Ｐ＜０．０１）。     

乙型肝炎肝内血管病变免疫组织化学观察

目的 研究乙型肝炎（乙肝）肝内血管病变与肝病变的关系。方法 ２７０例肝活检标本取自住院乙肝患者，选择１０例大致正常肝组织作对照。石蜡包埋，４μｍ切片，除依次作ＨＥ、弹力、网状及胶原杂色外另用特异性平滑肌肌动蛋白单克隆抗生进行免疫组织化学标记，结果 正常肝组织α－ＳＭＡ仅在原有的肝内动、静脉及胆管壁表达。乙肝病变较轻组肝组织α－ＳＭＡ示阳必表达占７５％；乙肝病变较重及肝硬变组肝组织α－ＳＭＡ示强阳性     

眼色素膜黑色素瘤的CT与MRI研究

目的研究色素膜黑色素瘤的ＣＴ和ＭＲＩ表现，探讨最佳ＭＲＩ的扫描序列。材料与方法１５例患者用各种ＭＲＩ序列进行扫描，其中１１例行ＣＴ扫描，并与手术病理进行对照。结果ＣＴ示９例表现为与眼外肌等密度的肿块，２例肿瘤太小未能显示。ＭＲＩ示１４例具有典型的短Ｔ１、短Ｔ２信号，１例３ｍｍ高度的虹膜黑色素瘤在Ｔ１ＷＩ上未能显示；１１例伴有视网膜脱离，呈短Ｔ１及长Ｔ２信号，与肿瘤在Ｔ１ＷＩ上很难区分。使用脂肪抑制和增强扫描的Ｔ１ＷＩ能较好地显示较小肿瘤（高度＜５ｍｍ）能区分肿瘤及其伴发的视网膜脱离。结论ＭＲＩ显示黑色素瘤的准确率和特异性较ＣＴ和Ｂ超优越。     

胃微小腺癌的组织发生研究

从２１０５例胃癌癌旁组织中找出微小腺癌３１例（〈０．１ｃｍ），观察其组织发生的特征，发现胃腺癌的发生有８种形式：①腺颈部干细胞癌变；②表面上皮癌变；③腺上皮癌变；④肠化生上皮癌变；⑤微腺囊癌变；⑥溃疡边缘上皮癌变；⑦扁平腺瘤癌变；⑧贲门交界处柱状上皮癌变。     

酵母菌2号培养最佳条件的选择

成人特发性乳糖酶缺乏症的发生率极高，这些人进食牛奶后会出现胃肠胀气、腹痛、腹泄等对牛奶不耐受的消化不良症状。为解决这一问题，自１９８９年起，国内外不少学者是主张有产替代疗法，即将人工培养制备纯化的乳糖酶直接加入牛奶中以水解其中的乳糖来弥补成人乳糖酶的缺乏。