复发性口疮(RAU)与唾液免疫球蛋白、补体及溶菌酶活性关系的实验研究

本文对９９例复发性口疮患者，分别在初诊治疗前（发作期）和治疗后３月未发作时进行唾液ＳＩｇＡ、ＩｇＧ、ＩｇＭ、Ｃ３、Ｃ４及溶菌酶含量和活性检测，并以４５名健康学生唾液相应成份作为正常对照。实验结果表明：复发性口疮患者治疗前唾液ＳＩｇＡ、ＩｇＧ、ＩｇＭ、Ｃ３、Ｃ４及溶菌酶含量和活性，均远远低于正常人唾液相应成份（Ｐ＜０．０１）；复发性口疮患者治疗后，其唾液ＳＩｇＡ、ＩｇＧ、ＩｇＭ、Ｃ３、Ｃ４及溶菌酶含量和活性，均较治疗前有显著提高（Ｐ＜０．０１），其中ＩｇＧ、Ｃ４及溶菌酶含量和活性恢复较明显，与正常人唾液相应成份相似（Ｐ＞０．０５）。     

An Automatic Channel Selection Approach for ICA-Based Motor Imagery Brain Computer Interface

Independent component analysis (ICA) is a potential spatial filtering method for the implementation of motor imagery brain-computer interface (MIBCI). However, ICA-based MIBCI (ICA-MIBCI) is sensitive to electroencephalogram (EEG) channels and the quality of the training data, which are two crucial factors affecting the stability and classification performance of ICA-MIBCI. To address these problems, this paper is mainly focused on the investigation of EEG channel optimization. As a reference, we constructed a single-trial-based ICA-MIBCI system with commonly used channels and common spatial pattern-based MIBCI (CSP-MIBCI). To minimize the impact of artifacts on EEG channel optimization, a data-quality evaluation method, named “self-testing” in this paper, was used in a single-trial-based ICA-MIBCI system to evaluate the quality of single trials in each dataset; the resulting self-testing accuracies were used for the selection of high-quality trials. Given several candidate channel configurations, ICA filters were calculated using selected high-quality trials and applied to the corresponding ICA-MIBCI implementation. Optimal channels for each dataset were assessed and selected according to the self-testing results related to various candidate configurations. Forty-eight MI datasets of six subjects were employed in this study to validate the proposed methods. Experimental results revealed that the average classification accuracy of the optimal channels yielded a relative increment of 2.8% and 8.5% during self-testing, 14.4% and 9.5% during session-to-session transfer, and 36.2% and 26.7% during subject-to-subject transfer compared to CSP-MIBCI and ICA-MIBCI with fixed the channel configuration. This work indicates that the proposed methods can efficiently improve the practical feasibility of ICA-MIBCI.     

Anti-apoptotic effect of Suxiao Jiuxin Pills against hypoxia-induced injury through PI3K/Akt/GSK3β pathway in HL-1 cardiomyocytes

Background

Suxiao Jiuxin Pill (SX), Chinese traditional medicine primarily consisting of tetramethylpyrazine and borneol, has been shown to protect against ischemic heart diseases. Nevertheless, the involved mechanism still remains unclear. The following study aimed to investigate the potential protective effect and molecular mechanisms of SX on apoptosis in HL-1 cardiomyocytes.

Modified Sauvé–Kapandji procedure for restoration of forearm rotation in devascularized hands

Introduction

The purpose of this study is to evaluate the clinical outcomes in patients with forearm rotation limitation after successful wrist-level revascularization who underwent a modified Sauvé–Kapandji (S–K) procedure.

Methods

This was a retrospective review of the clinical records of nine patients (three women, six men) after successful wrist-level revascularization who underwent late restoration of forearm rotation. All patients were evaluated using a Mayo Modified Wrist Score. The mean patient age was 35 (range 19–45) years. Mean time to reconstruction was 2.5 (range 0.5–4) years.

Results

Mean postoperative pronation was 74°; mean postoperative supination was 80°. Overall results were excellent/good in seven patients, fair in one, and poor in one. No bone bridge was formed between the pseudarthrosis in any patient. Two patients had neurapraxia. Moderate pain and snapping occurred in one patient during movement at the ulnar amputation site.

Conclusion

This modification of the S–K procedure can restore rotation of the forearm after hand revascularization; as such, it provides an alternative salvage procedure.     

椎间盘移植实验──生物力学研究

本实验在６只猴体上制备自体椎间盘移植模型，观察术后不同时期生理载荷下屈伸活动时移植椎间盘的刚度（ｓｔｉｆｆｎｅｓｓ）变化。结果表明：术后２月，移植的Ｌ３～４椎间盘在整个屈伸活动中较上、下正常对照椎间盘的变形增大；术后４月，移植椎间盘变形接近正常对照椎间盘；术后６月，移植椎间盘刚度明显恢复。实验结果提示术后早期有腰椎节段性不稳倾向，中晚期稳定性恢复，移植椎间盘可满足生理活动功能需要。     

椎间盘摘除术对腰椎稳定性的影响

本实验研究应用Ｅｌｉｔｅ三维立体摄像运动分析系统观察一个节段和多个节段椎间盘摘除对整个腰椎稳定性的影响。结果表明，单纯Ｌ４～５椎间盘摘除术后于屈曲３０°时，Ｌ４～５水平位移（Ｔｚ）及旋转位移（Ｒｘ）有明显增加。Ｌ４～５及Ｌ５～Ｓ１椎间盘同时摘除术后于屈曲１０°时，不但Ｌ４～５及Ｌ５～Ｓ１节段Ｔｚ和Ｒｘ显著增加，同时亦有相邻的Ｌ３～４节段活动显著增加。实验结果提示，椎间盘摘除术后，特别是多个椎间盘摘除术后，有导致腰椎在生理活动范围内出现手术节段及相邻节段不稳的倾向。     

骨盆巨大肿瘤的手术治疗

目的：探讨骨盆巨大肿瘤的手术治疗方法。方法我院自2000年1月-2007年12月共收治21例骨盆巨大肿瘤患者,男17例,女4例,平均55（35-65）岁。其中骶骨脊索瘤8例,髂骨软骨肉瘤5例,软骨母细胞瘤4例,骨巨细胞瘤3例,骨肉瘤1例,均采用双侧或单侧髂总动脉暂时阻断的方法行手术切除。结果所有患者术后获得0.5-6年（平均4年）随访,脊索瘤4例局部复发,1例死于肺部转移全身衰竭,1例于术后1年半死于肺部转移,其余无复发;8例出现手术部位不明原因疼痛不适。结论术中采用双侧或单侧髂总动脉暂时阻断的方法可明显减少术中出血,尽量彻底切除瘤体及维持骨盆稳定性等,可明显提高骨盆巨大肿瘤患者的手术疗效。     

Diagnostic significance of Wada procedure in very young children and children with developmental delay

Localization of vital components of neurological functioning has to be performed before epilepsy surgery can be considered in children with intractable epilepsy. This study reports the experience with the Wada procedure in very young children and/or developmentally delayed children with an a priori considerable chance of failing the procedure. The aim of this study was to indicate the applicability of this procedure in this patient group. The Wada procedure is described in 16 children under 10 years of age and/or have intelligence quotient scores below 50 and/or are critically ill and/or are behaviourally disturbed. Information on motor, language and memory functioning is obtained in respectively 13/15, 9/13, and 5/11 children. Nine children underwent epilepsy surgery without postoperative impairment of neurological functioning. In five children epilepsy surgery was not performed because of the results of the Wada procedure or the lack of information during the Wada procedure. One child became seizure-free before surgery. Even in very young, developmentally delayed or behaviourally disturbed children, the Wada test can provide important information with respect to the decision pro or contra epilepsy surgery.