全文获取类型
收费全文 | 3823篇 |
免费 | 378篇 |
国内免费 | 39篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 68篇 |
妇产科学 | 86篇 |
基础医学 | 455篇 |
口腔科学 | 104篇 |
临床医学 | 788篇 |
内科学 | 755篇 |
皮肤病学 | 22篇 |
神经病学 | 393篇 |
特种医学 | 211篇 |
外科学 | 350篇 |
综合类 | 108篇 |
一般理论 | 4篇 |
预防医学 | 400篇 |
眼科学 | 28篇 |
药学 | 257篇 |
中国医学 | 3篇 |
肿瘤学 | 198篇 |
出版年
2023年 | 28篇 |
2021年 | 60篇 |
2020年 | 39篇 |
2019年 | 50篇 |
2018年 | 66篇 |
2017年 | 34篇 |
2016年 | 43篇 |
2015年 | 67篇 |
2014年 | 69篇 |
2013年 | 124篇 |
2012年 | 130篇 |
2011年 | 156篇 |
2010年 | 107篇 |
2009年 | 98篇 |
2008年 | 146篇 |
2007年 | 160篇 |
2006年 | 152篇 |
2005年 | 146篇 |
2004年 | 146篇 |
2003年 | 126篇 |
2002年 | 105篇 |
2001年 | 124篇 |
2000年 | 109篇 |
1999年 | 110篇 |
1998年 | 136篇 |
1997年 | 110篇 |
1996年 | 100篇 |
1995年 | 87篇 |
1994年 | 80篇 |
1993年 | 78篇 |
1992年 | 91篇 |
1991年 | 80篇 |
1990年 | 79篇 |
1989年 | 77篇 |
1988年 | 86篇 |
1987年 | 46篇 |
1986年 | 57篇 |
1985年 | 56篇 |
1984年 | 57篇 |
1983年 | 31篇 |
1982年 | 36篇 |
1979年 | 38篇 |
1978年 | 33篇 |
1976年 | 29篇 |
1973年 | 29篇 |
1972年 | 30篇 |
1971年 | 27篇 |
1969年 | 28篇 |
1968年 | 34篇 |
1966年 | 34篇 |
排序方式: 共有4240条查询结果,搜索用时 15 毫秒
21.
Dr. Ronald L. Bauer MD Michael L. Palmer MD Andrea M. Bauer MSN RN CS Hector R. Nava MD Harold O. Douglass Jr. MD 《Annals of surgical oncology》1994,1(3):183-188
Background: The purpose of this study was to evaluate the tumor characteristics and treatment associated with an improved overall survival in patients with adenocarcinoma of the small intestine.
Methods: The records of all patients with primary adenocarcinoma of the small bowel seen between January 1971 and December 1991 were reviewed retrospectively. The study comprised 38 patients, 22 (58%) with duodenal tumors, 11 (29%) with jejunal tumors, and five (13%) with ileal tumors.
Results: Although not statistically significant, the patients with duodenal adenocarcinoma lived longer than the patients with jejunal or ileal lesions (p=0.77). The overall survival was 23% and seemed to correlate best with absence of lymph node metastases (p=0.04) and pancreaticoduodenectomy for localized duodenal tumors (p=0.04). The patient's age, duration of symptoms, disease-free interval, tumor location, type of recurrence, and histologic grade did not significantly influence survival.
Conclusions: The lethality of small-intestinal adenocarcinoma appears to be related to a delay in diagnosis and treatment. When a definitive surgical procedure is performed before lymph node metastases appear, the patient's chance for long-term survival is greatly improved.Presented at the 46th Annual Cancer Symposium of The Society of Surgical Oncology, Los Angeles, California, March 18–21, 1993. 相似文献
22.
Dr. S. K. Gupta J. C. Ritchie E. H. Ellinwood K. Wiedemann F. Holsboer 《European journal of clinical pharmacology》1992,43(1):51-55
Summary Changes in time course effected by cortisol suppression and the relationship of these changes to the plasma dexamethasone concentration of suppressor and non-suppressor patients are described in this report on a combined pharmacokinetic-pharmacodynamic model.Thirteen depressed patients (8 suppressors and 5 non-suppressors) received an intravenous dose (1.5 mg) of dexamethasone. The drug-induced effect changes are found to lag behind, in time, the plasma drug level changes. To accurately relate the temporal relationship of effect changes to plasma dexamethasone levels, a pharmacodynamic model (sigmoid-Emax) was combined with a pharmacokinetic model that incorporated an effect compartment. The magnitude of the time-lag was quantified by the half-time of equilibration between concentrations in the hypothetical effect compartment and the plasma dexamethasone levels (t&frac;keo).The t&frac;keo of the nonsuppressing group was about 50 of that of the suppressing group, indicating that for a given plasma level the onset and termination of effect for the nonsuppressing group is about two times more rapid than for the suppressing group. Moreover, the model can estimate the effect-site concentration that causes one-half of the maximal predicted effect (EC50), a measure of an individual's sensitivity to dexamethasone. The receptor sensitivity (as determined from the EC50 ratio) of the suppressing group was about twice that of the nonsuppressing group. 相似文献
23.
24.
Mr. Richard M. Reichley B.S. Pharm. Dr. David J. Ritchie Pharm.D. Dr. Thomas C. Bailey M.D. 《Pharmacotherapy》1995,15(5):625-630
Predicted gentamicin elimination rate constants (kels) using creatinine clearance (C1cr) estimates from seven equations were compared with kels calculated from steady-state serum gentamicin concentrations in 186 hospitalized patients. In predicting kel, the equations varied significantly in precision (mean absolute percentage error), and were particularly imprecise among patients with serum creatinine values of 71 μmol/L or less. Significant differences in bias (mean prediction error) were also observed. All equations using serum creatinine as an element showed improved precision, and most showed reduced bias when a minimum value of 71 μmol/L was used. The Cockcroft-Gault normalized to 72 kg and the Hull equations are among the simplest to calculate and, when using a minimum serum creatinine of 71 μmol/L, had significantly greater precision and less bias than several of the equations. We recommend one of these two methods for predicting gentamicin kel in patients with low serum creatinine values. 相似文献
25.
Action of three ectopeptidases on corticotropin-releasing factor: metabolism and functional aspects.
Using purified enzyme preparations, we investigated the actions of angiotensin-converting enzyme, aminopeptidase N, and endopeptidase 24.11 on corticotropin-releasing factor (CRF). The effects of inhibition of these enzymes on CRF action in rat anterior pituitary cultures were also determined. Finally, specific inhibitors were used to evaluate ectopeptidase action on the regional brain metabolism of CRF. K(m) values for CRF were 165, 90, and 42 microM for angiotensin-converting enzyme, aminopeptidase N, and endopeptidase 24.11, respectively. A CRF metabolite profile for each enzyme was determined. In pituitary cultures, inhibition of endopeptidase 24.11 and aminopeptidase N potentiated CRF-stimulated release of adrenocorticotropic hormone (ACTH). In rat pituitary and hypothalamus membrane preparations, specific inhibitor experiments indicated that CRF hydrolysis involved members of the neutral endopeptidase and aminopeptidase enzyme families. In cortex membranes, similar peptidase inhibition was without effect. These data support the hypothesis that ectopeptidases play a major role in CRF metabolism and biological function. 相似文献
26.
Nancy J. Fishwick RN PhD CS 《Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG》1998,27(6):661-670
Nearly 4 million women in the United States were physically hurt by their husbands or boyfriends in 1994. The health and well-being of these women and their children, as well as the women who are overlooked in these statistics, are jeopardized by past and current experiences with abuse within intimate relationships. Strategies for nurses in women's health care settings to screen women for current or past abuse within their intimate personal relationships, guidelines for effective responses to disclosure of abuse, and supportive interventions are described. 相似文献
27.
28.
Sarah L. Turner Trudy L. Horton Pamela Ritchie John D. Horton 《Developmental and comparative immunology》1991,15(4):319-328
A miniaturized, “hanging-drop” bioassay reveals that splenocytes from earlythymectomized (Tx) Xenopus can respond (by enhanced thymidine incorporation) to thymicdependent “cytokines” generated in PHA- or alloantigen-stimulated cultures. Preliminary evidence, using fluorescence activated cell sorting, indicates that surface IgM− splenocytes, rather than sIgM+ cells, from Tx toads are sensitive to the crude, splenocyte-derived, active supernatants. Although these responsive cells display residual, but low, reactivity to PHA, their thymus independence is suggested by flow cytometric observations using the anti-T cell monoclonal antibody XT-1. The development of “T-like” cells in Tx Xenopus is discussed. 相似文献
29.
30.