Observations on the therapeutic effect of acupuncture plus tuina on retention of urine

将118例尿潴留患者随机分为2组,即针灸推拿治疗组和药物注射治疗组分别进行治疗观察.结果2组疗效有显著差异.并对2组治疗效果、治疗次数、疗效影响等比较分析,提示针灸推拿组显效率明显优于药物注射组.反映针灸配合推拿治疗尿潴留是临床一种较好的治疗方法.     

银翘解毒丸中金银花药材HPLC-UV鉴定及绿原酸含量测定

目的:建立银翘解毒丸(金银花,连翘,甘草,薄荷等)中金银花药材的鉴别和绿原酸含量测定的方法.方法:采用YWG C18色谱柱;甲醇-10%的磷酸氢二钠(冰醋酸调pH值为2.7)为流动相进行梯度洗脱;检测波长为326nm;流速为1.0mL·min-1;柱温为室温.结果:HPLC-UV法定性鉴别制剂中金银花药材;绿原酸在5.0～60μg·mL-1的范围内呈良好线性关系(r=0.9999),平均回收率为98.71%(RSD=1.57%).结论:本法操作简单,准确,重现性好,可用于银翘解毒丸的质量控制.     

Lnczc3h7a对结直肠癌细胞增殖和迁移的影响及其机制

目的 分析Lnczc3h7a在结直肠癌细胞中的表达及其对结肠癌细胞增殖和迁移的影响,并探讨其潜在的作用机制.方法 选择6种结直肠癌细胞株SW620、SW480、HCT116、DLD-1、Caco-2、HT-29与正常结直肠上皮细胞株FHC,采用RT-PCR法检测Lnczc3h7a在结直肠癌细胞株及正常结直肠上皮细胞株中...     

Determination of heavy metals in water using an FTO electrode modified with CeO2/rGO nanoribbons prepared by an electrochemical method

The rGO/CeO₂/FTO nanocomposite modified electrode was prepared by an electrochemical method. A simple and highly sensitive electrochemical sensing platform for electrochemical rGO and modified CeO₂ nanoribbons directly on FTO electrodes was developed. Simultaneous determination of Pb²⁺ and Cd²⁺ used the differential pulse anodic stripping voltammetry (DPASV) method. The method was simple to operate, and CeO₂ nanobelts could be obtained simultaneously by electrodeposition and reduction of GO without further processing. This is an environmentally friendly electrochemical method to obtain modified electrodes under mild conditions. The experimental results showed that the linear calibration curves of Pb²⁺ and Cd²⁺ are 1–300 and 0.2–500 μg L⁻¹, respectively. At the same time, no interference from other coexisting metal ions was found during the detection process, which proved that the modified electrode had good stability and repeatability.

The rGO/CeO₂/FTO nanocomposite modified electrode was prepared by an electrochemical method.     

Improved nitrogen reduction activity of NbSe2 tuned by edge chirality

Efficient catalysts for the electroreduction of N₂ to NH₃ are of paramount importance for sustainable ammonia production. Recently, it was reported that NbSe₂ nanosheets exhibit an excellent catalytic activity for nitrogen reduction under ambient conditions. However, existing theoretical calculations suggested an overpotential over 3.0 V, which is too high to interpret the experimental observations. To reveal the underlying mechanism of the high catalytic activity, in this work, we assessed NbSe₂ edges with different chirality and Se vacancies by using first principles calculations. Our results show that N₂ can be efficiently reduced to NH₃ on a pristine zigzag edge via the enzymatic pathway with an overpotential of 0.45 V. Electronic structure analysis demonstrates that the N₂ molecule is activated by the back-donation mechanism. The efficient tuning of the local chemical environments by edge chirality provides a promising approach for catalyst design.

The zigzag edge of the NbSe₂ monolayer exhibits an overpotential as low as 0.45 V along the enzymatic pathway.     

细针穿刺肝脏孤立性坏死结节的临床病理特征

目的研究B超下穿刺肝孤立性坏死结节的临床及病理学特点。方法收集32例肝孤立性坏死结节的临床资料,并在光镜下观察其细针穿刺组织病理形态,同时复习相关文献。结果本组男性21例,女性11例,平均年龄46.8岁,结节直径0.8~4.0 cm,临床及影像学缺少特异表现,光镜下结节中央为凝固性坏死,坏死外周围绕着一层弹力纤维及胶原组织,伴少数炎细胞浸润,结节周围的肝细胞基本正常。结论肝孤立性坏死结节是一种少见的非肿瘤性结节状病变,对B超引导下穿刺标本进行组织病理学观察能够准确诊断。     

A Novel Herbal Extract Blend Product Prevents Particulate Matters-Induced Inflammation by Improving Gut Microbiota and Maintaining the Integrity of the Intestinal Barrier

Air pollutants of PM2.5 can alter the composition of gut microbiota and lead to inflammation in the lung and gastrointestinal tract. The aim of this study was to evaluate the protective effect of a novel herbal extract blend, FC, composed of Lonicera japonica extract, Momordica grosvenori extract, and broccoli seed extract, on PM2.5-induced inflammation in the respiratory and intestinal tract. A549 cells and THP-1 cells, as well as C57BL/6 mice, were stimulated with PM2.5 to establish in vitro and in vivo exposure models. The models were treated with or without FC. The expression of inflammatory cytokines and tight junction proteins were studied. Proteomic analysis was performed to elucidate mechanisms. Mouse feces were collected for gut microbiota analysis. FC was shown to modulate the upregulation of pro-inflammatory cytokines mRNA expression in A549 and THP-1 cells and downregulated tight junction proteins mRNA expression in A549 cells due to PM2.5 stimulation. In animal models, the decreased expression of the anti-inflammatory factor il-10, tight junction protein ZO-1, and the elevated expression of COX-2 induced by PM2.5 were improved by FC intervention, which may be associated with zo-1 and cox-2 signaling pathways. In addition, FC was shown to improve the gut microbiota by increasing the abundance of beneficial bacteria.     

Liquid Guayule Natural Rubber,a Sustainable Processing Aid,Enhances the Processability,Durability and Dynamic Mechanical Properties of Rubber Composites

Petroleum-based oils are widely used as processing aids in rubber composites to improve processability but can adversely affect rubber composite performance and increase carbon footprint. In this research, liquid guayule natural rubber (LGNR), produced from guayule natural rubber, was used as a renewable processing aid to replace naphthenic oil (NO) in Hevea natural rubber, styrene-butadiene rubber (SBR) and guayule natural rubber (GNR) composites. The rheological properties, thermal stability, glass transition temperature, dynamic mechanical properties, aging, and ozone resistance of rubber composites with and without NO or LGNR were compared. Natural and synthetic rubber composites made with LGNR had similar processability to those made with NO, but had improved thermal stability, mechanical properties after aging, and ozone resistance. This was due to the strong LGNR–filler interaction and additional crosslinks formed between LGNR and the rubber matrices. The glass transition temperature of SBR composites was reduced by LGNR because of its increased molecular mobility. Thus, unlike NO, LGNR processing aid can simultaneously improve rubber composite durability, dynamic performance and renewability. The commercialization of LGNR has the potential to open a new sustainable processing-aid market.     

不同模式新辅助治疗食管癌的疗效分析

目的 探讨食管癌不同模式新辅助治疗的疗效分析。方法 回顾性分析2015年1月至2022年5月于安阳市肿瘤医院行新辅助治疗的食管鳞癌(ESCC)患者的资料,共纳入542例患者,其中放化疗(NCRT)组137例,化疗(NCT)组241例,免疫加化疗(NICT)组164例;女性198例,男性344例;≤65岁289例,＞65岁253例。首要研究终点包括主要病理缓解(MPR)率、病理完全缓解(pCR) 率,次要研究终点包括总生存(OS)、无进展生存(PFS)和安全性。生存分析采用Kaplan-Meier方法,并采用Log-rank检验进行组间比较。采用Cox比例风险回归模型进行预后因素分析。结果 NCRT组的MPR率和pCR率分别为66.4%(91/137)和35.8%(49/137),NCT组分别为35.3%(85/241)和6.6%(16/241),NICT组分别为63.4%(104/164)和31.1%(51/164)(χ²=1.67, P＜0.001)。NCRT组的1、2、3年的OS分别为89.8%、82.3%、72.3%,NCT组分别为85.9%、71.4%、61.4%,NICT组分别为91.9%、81.5%、77.8%,差异有统计学意义(χ²=9.20,P＜0.01);NCRT组的1、2、3年的PFS分别为81.5%、67.9%、66.6%,NCT组分别75.9%、61.0%、53.5%,NICT组分别为80.1%、65.5%、65.3%,差异有统计学意义(χ²=4.62,P＜0.05)。多因素分析显示,治疗方式、T分期、N分期是OS的独立影响因素(P＜0.05)。3组不良反应及术后并发症差异无统计学意义(P＞0.05)。结论 与NCT对比,NICT与NCRT有更高的pCR、MPR和生存获益,因此新辅助免疫可作为食管癌术前治疗手段之一,但仍需大型的随机对照研究进一步证实。