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711.
Microstructural assessment of rare corneal dystrophies using real-time in vivo confocal microscopy 总被引:1,自引:0,他引:1
Christina N Grupcheva MD Tahira Y Malik FRCOphth Jennifer P Craig PhD Trevor Sherwin PhD Charles NJ McGhee PhD FRANZCO 《Clinical & experimental ophthalmology》2001,29(5):281-285
Purpose : To analyse and describe three cases of rare corneal dystrophy and highlight their in vivo microstructural features. Methods : Subject 1 was diagnosed with a posterior stromal fleck corneal dystrophy. Two of her three children were also affected. Subjects 2 and 3 exhibited an almost identical clinical appearance on biomicroscopic examination, such that both clinically were diagnosed as having pre‐Descemet’s dystrophies. All subjects underwent in vivo confocal microscopy and approximately 300 sequential digital images were obtained and analysed for each cornea. Results : In vivo confocal microscopy of subject 1 demonstrated an abnormal appearance of numerous large ovoid particles, measuring 50–70 μm in diameter in the mid and posterior stroma as well as smaller hyperreflective dot‐like intracellular deposits, of less than 1 μm diameter. Despite the near‐identical clinical appearance, subjects 2 and 3 could be clearly differentiated by in vivo confocal microscopy. Subject 2 exhibited small, irregular, optically dense particles, mainly in the anterior stroma, whereas subject 3 possessed classical involvement of the stroma immediately adjacent to Descemet’s membrane, with numerous regular, small, hyperreflective particles. Conclusions : The ability of in vivo confocal microscopy to localize and accurately measure various elements in different corneal layers may help to resolve whether abnormalities are intra‐ or extracellular, and aid clearer differentiation of rare corneal disorders. 相似文献
712.
Yi Wei Goh MBChB Charles NJ McGhee PhD FRCOphth Dipika V Patel PhD MRCOphth Rachel Barnes MBChB FRANZCO Stuti Misra MSc BOptom 《Clinical & experimental optometry》2014,97(3):274-277
Traditionally, photodynamic therapy (PDT) has been used to treat choroidal neovascularisation. More recently, its use in corneal neovascularisation has provided promising clinical results. The major advantage of PDT is that it is minimally invasive, resulting in closure of the neovascular network without damaging the surrounding healthy tissue. This report describes the positive results of PDT, clinically and microstructurally, as imaged by in vivo confocal microscopy, for treating corneal neovascularisation with lipid keratopathy, secondary to herpes zoster infection. 相似文献
713.
Estimation of aneuploidy for chromosomes 3, 7, 16, X and Y in spermatozoa from 10 normospermic men using fluorescence in-situ hybridization 总被引:3,自引:0,他引:3
Fluorescence in-situ hybridization (FISH) is a fast and efficient method of
estimating aneuploidy in human spermatozoa. In this study, we have
estimated baseline disomy frequencies in spermatozoa from a group of 10
normospermic men, using stringent scoring criteria. A triple- probe FISH
procedure was used for chromosomes 3, X and Y, while a double-probe FISH
method was used for chromosomes 7 and 16. A total of 101273 spermatozoa
were scored for chromosomes 3, X and Y, resulting in 97.83% haploidy (3X or
3Y), 0.39% disomy (33X, 33Y, 3XX, 3YY or 3XY) and 0.35% diploidy (33XX,
33YY or 33XY). A total of 100760 spermatozoa were scored for chromosomes 7
and 16, giving 98.9% haploidy (716), 0.11% disomy (7716 or 71616) and 0.27%
diploidy (771616). Disomy frequencies for individual chromosomes differed
(chromosome 3, 0.20%; chromosome 7, 0.05%, chromosome 16, 0.06%; X + Y,
0.19%). The frequency of disomy 3 was significantly higher than disomy 7 (P
= 0.019) and disomy 16 (P = 0.022), while the frequency of sex chromosome
disomy was significantly higher than disomy 7 (P = 0.0058) and disomy 16 (P
= 0.0067), but not disomy 3 (P = 0.73). The disomy and diploidy (0.27-
0.35%) estimates obtained for this normospermic population were generally
low and were similar to other recent reports.
相似文献
714.
M. T. PITKÄNEN P. H. ROSENBERG P. J. PERE M. K. TUOMINEN T. A. SEPPÄLÄ 《Anaesthesia》1992,47(5):395-398
The effect of the addition of 0.1 mg or 0.2 mg fentanyl to 40 ml 0.5% prilocaine in intravenous regional anaesthesia of the arm was investigated in 37 patients in a randomised, double-blind study. The characteristics of the sensory and motor block were studied. There was no difference in the speed of onset of analgesia in the groups (mean latency approximately 4 min in each group). However, significantly more patients in the fentanyl 0.2 mg group (7/12) had complete anaesthesia at 15 min than in the fentanyl 0.1 mg group (1/13) and the control group (2/12) (p less than 0.05). There were no differences in the incidence of tourniquet pain immediately before cuff deflation (tourniquet time 45-87 min). After cuff deflation, in those patients who complained of wound pain within 30 min, on average the pain appeared later in the fentanyl 0.2 mg group (six patients, mean 14.3 min) than in the control group (eight patients, mean 9.4 min) (ns). In the fentanyl groups, the incidence of central nervous system side effects was greater than in the control group (fentanyl 0.1 mg 7/13 patients, fentanyl 0.2 mg 6/12 patients, control 1/12 patients) (p less than 0.05). The plasma concentrations of prilocaine after cuff deflation were higher, in a dose-dependent fashion, in the fentanyl groups than in the control group, but the concentrations of prilocaine and fentanyl did not correlate with the symptoms. Postoperative nausea occurred only in the patients who had received fentanyl. 相似文献
715.
T. TAIVAINEN M. PITKNEN M. TUOMINEN P. H. ROSENBERG 《Acta anaesthesiologica Scandinavica》1993,37(7):702-705
This prospective investigation was conducted to evaluate the efficacy of different volumes of epidural blood patch (EBP) for treatment of postdural puncture headache (PDPH) in 81 consecutive patients. In the first part of the investigation (Study part I), 10 ml of blood was injected for EBP in 28 patients. In the second randomized part of the investigation (Study part II), the patients were allocated to receive for EBP either 10 ml (27 patients) or 10–15 ml (26 patients), according to the height of the patient. The procedure was considered initially successful if PDPH disappeared completely during the 2–h recovery room follow–up. To evaluate the long–term success, a questionnaire was mailed to all patients. The EBP performed 3.7± 2.9 days following the dural puncture was initially successful in 88–96% of the patients in the different study groups. In the questionnaire, only 50–68% of the patients reported that PDPH had disappeared immediately without recurrence. In 16–36% of the patients the PDPH returned at lesser intensity and in 14–17% PDPH was reported to have continued, disappearing gradually in all patients. Despite this, 87% of all patients were satisfied with the EBP treatment. There were no statistically significant differences between the groups. The results indicate that a larger, height–adjusted volume of blood for EBP in adults does not produce a better effect on PDPH compared to a standard 10–ml volume. Despite the excellent initial effect (91%) seen in our patients, a permanent effect of the blood patch was only achieved in 61%. 相似文献
716.
717.