收费全文 | 1660350篇 |
免费 | 136678篇 |
国内免费 | 2689篇 |
耳鼻咽喉 | 22215篇 |
儿科学 | 54617篇 |
妇产科学 | 47333篇 |
基础医学 | 235424篇 |
口腔科学 | 48368篇 |
临床医学 | 147879篇 |
内科学 | 325467篇 |
皮肤病学 | 34900篇 |
神经病学 | 135132篇 |
特种医学 | 66948篇 |
外国民族医学 | 476篇 |
外科学 | 252742篇 |
综合类 | 40600篇 |
现状与发展 | 3篇 |
一般理论 | 613篇 |
预防医学 | 129648篇 |
眼科学 | 37759篇 |
药学 | 125518篇 |
34篇 | |
中国医学 | 3101篇 |
肿瘤学 | 90940篇 |
2018年 | 16091篇 |
2016年 | 13895篇 |
2015年 | 16190篇 |
2014年 | 22348篇 |
2013年 | 33780篇 |
2012年 | 46150篇 |
2011年 | 48444篇 |
2010年 | 28448篇 |
2009年 | 27150篇 |
2008年 | 46246篇 |
2007年 | 48807篇 |
2006年 | 49539篇 |
2005年 | 48042篇 |
2004年 | 47237篇 |
2003年 | 45217篇 |
2002年 | 44146篇 |
2001年 | 76781篇 |
2000年 | 79402篇 |
1999年 | 67406篇 |
1998年 | 18436篇 |
1997年 | 16898篇 |
1996年 | 16879篇 |
1995年 | 16575篇 |
1994年 | 15576篇 |
1993年 | 14651篇 |
1992年 | 56104篇 |
1991年 | 54356篇 |
1990年 | 53127篇 |
1989年 | 51356篇 |
1988年 | 47681篇 |
1987年 | 47025篇 |
1986年 | 44747篇 |
1985年 | 43319篇 |
1984年 | 32465篇 |
1983年 | 27913篇 |
1982年 | 16462篇 |
1981年 | 14734篇 |
1980年 | 13828篇 |
1979年 | 30781篇 |
1978年 | 21357篇 |
1977年 | 18009篇 |
1976年 | 16913篇 |
1975年 | 17790篇 |
1974年 | 21754篇 |
1973年 | 20903篇 |
1972年 | 19097篇 |
1971年 | 17961篇 |
1970年 | 16491篇 |
1969年 | 15462篇 |
1968年 | 14130篇 |
Background
In November 2017, the World Health Organization received initial reports of suspected diphtheria cases in camps established for displaced Rohingyas in Cox’s Bazar district, Bangladesh. By January 11, 2018, over 4,000 suspected cases of diphtheria and 30 deaths were reported. The Bangladesh government and partners implemented a diphtheria vaccination campaign in December 2017. Outbreak response staff reported anecdotal evidence of vaccine hesitancy. Our assessment aimed to understand vaccination barriers and opportunities to enhance vaccine demand among displaced Rohingyas in Bangladesh.Methods
In January 2018, we conducted a qualitative assessment consisting of nine focus group discussions and 15 key informant interviews with displaced Rohingyas in three camps. Participants included mothers and fathers with under five-year-old children, community volunteers, majhis (camp leaders), Islamic religious leaders, traditional and spiritual healers, and teachers. We recruited participants using purposive sampling, and analyzed the data thematically.Results
Across focus groups and in-depth interviews, trusted information sources cited by participants included religious leaders, elders, village doctors, pharmacists, majhis, and mothers trained by non-governmental organizations to educate caregivers. Treatment of diphtheria and measles was usually sought from multiple sources including traditional and spiritual healers, village doctors, pharmacies, and health clinics. Major barriers to vaccination included: various beliefs about vaccination causing people to become Christian; concerns about multiple vaccines being received on the same day; worries about vaccination side effects; and, lack of sensitivity to cultural gender norms at the vaccination sites.Conclusion
Although vaccination was understood as an important intervention to prevent childhood diseases, participants reported numerous barriers to vaccination. Strengthening vaccine demand and acceptance among displaced Rohingyas can be enhanced by improving vaccination delivery practices and engaging trusted leaders to address religious and cultural barriers using community-based channels. 相似文献Background
Post-stroke dysphagia is characterized by reduced corticolingual excitability and lingual pressure; however, it remains unknown if transcranial magnetic stimulation (TMS) directly facilitates lingual pressure generation. 相似文献Objectives
Triazole resistance in Aspergillus spp. is emerging and complicates prophylaxis and treatment of invasive aspergillosis (IA) worldwide. New polymerase chain reaction (PCR) tests on broncho-alveolar lavage (BAL) fluid allow for detection of triazole resistance at a genetic level, which has opened up new possibilities for targeted therapy. In the absence of clinical trials, a modelling study delivers estimates of the added value of resistance detection with PCR, and which empiric therapy would be optimal when local resistance rates are known.Design
A decision-analytic modelling study was performed based on epidemiological data of IA, extended with estimated dynamics of resistance rates and treatment effectiveness. Six clinical strategies were compared that differ in use of PCR diagnostics (used vs not used) and in empiric therapeutic choice in case of unknown triazole susceptibility: voriconazole, liposomal amphotericin B (LAmB) or both. Outcome measures were proportion of correct treatment, survival and serious adverse events.Results
Implementing aspergillus PCR tests was projected to result in residual treatment-susceptibility mismatches of <5% for a triazole resistance rate up to 20% (using voriconazole). Empiric LAmB outperformed voriconazole at resistance rates >5–20%, depending on PCR use and estimated survival benefits of voriconazole over LAmB. Combination therapy of voriconazole and LAmB performed best at all resistance rates, but the advantage over the other strategies should be weighed against the expected increased number of drug-related serious adverse events. The advantage of combination therapy over LAmB monotherapy became smaller at higher triazole resistance rates.Conclusions
Introduction of current aspergillus PCR tests on BAL fluid is an effective way to increase the proportion of patients that receive targeted therapy for IA. The results indicate that close monitoring of background resistance rates and adverse drug events are important to attain the potential benefits of LAmB. The choice of strategy ultimately depends on the probability of triazole resistance, the availability of PCR and individual patient characteristics. 相似文献Methods: This retrospective, non-randomized, interventional comparative study included 38 eyes of 38 patients. All cases underwent PPV with silicone oil tamponade. The main outcome measure was improvement of final visual acuity relative to the presenting visual acuity and factors affecting the same Group A included eyes with favorable vision of 20/400 or better and Group B included the others.
Results: Group A included 16 eyes (42.10%), group B included 22 eyes (57.89%). In Group A 2 eyes out of 16 (12.5%) and in Group B 12 eyes out of 22 (54.54%) had RRD at presentation (p = 0.02, 95% CI for the difference 7.88–65.78%). The time interval between first presentation and development of RRD in Group A was 30.94 ± 38.8 days (median 30 days) whereas that in Group B was 10.81 ± 11.73 days (median 8 days) (p = 0.02). The odds of visual improvement post-vitrectomy when RRD occurred later was 8.4 (p = 0.01, 95% CI 1.53–46.1). The usage of systemic steroids (odds 5.2, p = 0.03, 95% CI 1.14–23.54) and oral valacyclovir (odds 4.33, p = 0.04, 95% CI 1.05–17.84) were associated with odds favoring a good visual outcome. Recurrent RRD was noted in 3/16 eyes (18.75%) in Group A and 13/22 eyes (59.09%) in Group B (p = 0.03).
Conclusion: Delayed occurrence of RRD after ARN is a good prognostic factor. Usage of systemic steroids and oral valacylocvir are associated with a favorable visual outcome when started before the onset of RRD. 相似文献