Angiographic uterine artery embolization followed by immediate curettage: an efficient treatment for controlling heavy bleeding and avoiding recurrent bleeding in cervical pregnancy

Two cases of cervical pregnancy with heavy bleeding successfully treated by uterine artery embolization (UAE) followed by immediate curettage are described in this report. Case 1 demonstrated intermittent bleeding after serious bleeding was successfully controlled by UAE. Serum beta human chorionic gonadotropin (beta-hCG) level rose remarkably after a short time decline. Transvaginal sonography consistently revealed a heterogeneous mass in the cervix. Repeated UAE followed by immediate curettage was performed and complete resolution was achieved. Case 2 was also successfully managed by UAE followed by immediate curettage after failure of medical treatment. This report suggests that UAE followed by immediate curettage is a safe and efficient procedure for controlling heavy bleeding and avoiding recurrent bleeding when fertility capacity is desired in cases of cervical pregnancy with fetal cardiac activity and high beta-hCG concentration.     

Matrix metalloproteinase-1 promoter polymorphism and epithelial ovarian cancer: does ethnicity matter?

AIM: To estimate the relationship between matrix metalloproteinase (MMP)-1 promoter -1607 bp polymorphism and the risk of epithelial ovarian cancer (EOC) in Korean women and to clarify the ethnic difference in genotype distribution of this polymorphism. METHODS: Single nucleotide polymorphism (SNP) of MMP-1 promoter -1607 region in 133 EOC patients and 332 cancer-free patients were investigated. Then the associations of this polymorphism with EOC or its clinicopathological parameters were analyzed. In addition, genotype distributions of this polymorphism in Korean women were compared with those of other races by extracting data from the previously published literature. RESULTS: We found no relationship between MMP-1 promoter -1607 bp polymorphism and epithelial ovarian cancer in a Korean population. Furthermore, we found ethnicity-dependent differences in genotype distributions and allele frequencies by comparison with previous articles on this topic. We report significant ethnic differences in the genotype distributions and allele frequencies of the MMP-1 promoter -1607 bp polymorphism. CONCLUSION: Our results indicate that MMP-1-1607 bp polymorphism shows ethnic diversity, and that the hypothesis that this polymorphism is associated with epithelial ovarian cancer is not supported by this study in a Korean population. Moreover, this finding concurs with results obtained in white Americans and Europeans.     

非甾体类抗炎药在皮肤病治疗上的研究进展

非甾体类抗炎药（nonsteroidal anti-inflammatory drugs,NSAIDs）是-类具有解热镇痛、抗炎作用的药物.在皮肤科广泛应用于炎症性疾病.近期研究发现,NSAIDs除具有传统的治疗作用外,在紫外线相关性疾病和皮肤肿瘤的预防和治疗上也有显著的疗效.该文就这几方面的研究进展作一综述.     

首发精神分裂症患者IL-1β的血清蛋白水平及PBMC mRNA表达

目的从基因转录和蛋白水平,观察精神分裂症中IL-1β的动态变化情况,了解其免疫状态,并探讨IL-1β与精神病理的关系。方法采用病例对照研究方法,精神分裂症组为根据DSM—Ⅳ诊断为精神分裂症的本地汉族患者83例,单一应用利培酮治疗,在治疗前后评定PANSS量表;对照组为健康志愿者65例。应用ELISA和RT—PCR方法,同时检测血清IL-1β蛋白水平和PBMC中IL-1β mRNA表达。结果（1）精神分裂症组治疗前、后与对照组血清IL--1β水平相比,均明显增高,差异有显著性（P〈0．05）。精神分裂症组治疗后血清IL—-1β水平与治疗前相比明显下降,差异有显著性（P〈0．05）。（2）IL-1β治疗前后的差值与PANSS量表降分率呈显著正相关（r=0．388,P〈0．05）。（3）精神分裂症组治疗前、后PBMC中IL-1β mRNA表达与对照组相比明显增高,差异有显著性（P〈0．05）。精神分裂症组治疗后PBMC中IL-1β mRNA表达与治疗前相比明显下降,差异有显著性（P〈0．05）。结论（1）精神分裂症患者存在免疫激活,IL-1β水平的变化可作为病情缓解的一个灵敏指标。（2）精神分裂症患者PBMC呈激活状态,是IL-1β的主要来源之一,探讨影响PBMC细胞因子mRNA表达的因素,有助于反映对机体的免疫状况的影响。     

国际卫生保健体制中筹资方式的比较与思考

本文通过对美国、英国、新加坡、澳大利亚几种典型筹资方式的分析，结合中国历史、现状及存在问题，描述中国城市的公费、劳保医疗及农村的合作医疗的筹资方式及变迁。分析存在问题和挑战，提出设置卫生税、采用具有储蓄制的合作医疗制度，建立医疗救助基金。为探讨今后的筹资办法作一些有益的思考。     

老年性胆道疾病患者急诊外科手术治疗的临床观察

目的 探讨老年性胆道疾病患者急诊外科手术治疗的术式与疗效.方法 回顾性分析本院收治的56例老年性胆道疾病患者的病例资料,所有患者均为急诊手术治疗,并随机分为两组,治疗组使用改良胆总管空肠Roux-en-y吻合术进行治疗,对照组使用胆管十二指肠吻合术进行治疗,并对两组疗效进行对比.结果 治疗组各项指标均高于对照组,差异有统计学意义（P〈0.05）.结论 改良胆总管空肠Roux-en-y吻合术治疗老年胆道疾病患者的远期疗效要高于胆管十二指肠吻合术,其可作为急诊手术的首选手术术式.     

黑米花色素苷对大鼠血液生化指标和巨噬细胞功能影响的研究

目的观察黑米花色素苷(black rice anthocyanin,BA)对大鼠血液生化指标的影响及其对腹腔巨噬细胞(peritoneal macrophage,PM)与肺泡巨噬细胞(alveolar macrophage,AM)的激活作用,探讨其对大鼠的免疫调节作用。方法雌性SD大鼠24只,随机分为对照组和BA低(BAL,25mg/kgbw),中(BAM,50mg/kgbw),高(BAH,100mg/kgbw)剂量组4组。除对照组给生理盐水外,另三组分别给予相应剂量的BA,1/d连续30d。实验结束时,从股动脉取血,用生化方法测定巨噬细胞内乳酸脱氢酶(LDH)、酸性磷酸酶(ACP)、超氧化物歧化酶(SOD)活力、及丙二醛(MDA)含量,并进一步观察巨噬细胞摄取中性红的能力。结果BA组大鼠血液中尿素氮(UN)、尿酸(UA)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)水平都有不同程度的降低,PM内ACP、LDH活力显著升高,PM和AM内SOD活力升高,MDA水平降低,而且能显著增强PM、AM的吞噬能力。结论BA对大鼠血液和巨噬细胞生化指标有重要的免疫调节作用。     

圣脑康丸防治急性高原反应的现场观察

目的研究圣脑康丸对急性高原反应的即时防治效果。方法随机选择54名空运至拉萨(海拔3 700 m)的新兵,分为对照组(n=18)、红景天组(n=18)、圣脑康组(n=18),在进入高原前3 d开始分别服用空白胶囊、红景天胶囊、圣脑康丸,连续服用至进入高原的第7天止,定期测定血氧饱和度(SaO2)和心率(HR),以军用卫生标准GJB1098-91《急性高原反应的诊断和处理原则》随访记录受试者急性高原反应症状并评分。结果圣脑康组预防急性高原反应的效果明显优于对照组,圣脑康组急性高原反应评分以及进入高原第1,3,5天时的血氧饱和度(SaO2)和心率(HR)均显著优于对照组(P<0.05或0.01)。结论圣脑康丸能减轻缺氧症状的严重程度,降低急性高原反应的发生率,具有防治急性高原反应的功效。