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Mohamed Safwan Priya Ramachandran Mettu Srinivas Reddy Naresh Shanmugam Mohamed Rela 《Pediatric transplantation》2016,20(8):1045-1050
LT has played a significant role in improving the outcome of children with BA. We review our five‐yr experience of LDLT for children with BA. Records of all children who underwent LDLT in our institution over a five‐yr period (August 2010–June 2015) were reviewed and those with a primary diagnosis of BA were selected for our study. Data were extracted from a prospectively maintained database. Additional data were collected by review of case notes and imaging studies. Analysis was carried out using standard statistical means. One hundred and thirty‐two children underwent LDLT at our center over the study period, of which 58 children (31 females) had a primary diagnosis of BA. Thirty‐three (56.9%) children had undergone a prior KPE and 25 (43.1%) had a primary LT. Thirty‐four children had at least one post‐op complication, of which 13 had minor complications (Clavien grades I and II) and 21 had major complications (Clavien grade >II). Thirty‐day survival was 96.6% and one‐yr survival was 91.4%. Univariate analysis of variables comparing children who did and did not have a KPE prior to LT showed that age at LT, weight at LT, PELD, and GRWR were significantly different. LDLT provides excellent outcomes in children with BA. Primary LDLT and LT after KPE provide equivalent results, although the former is technically more challenging as the child is younger. 相似文献
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Ashok Apurva Niyogi Devayani Ranganathan Priya Tandon Sandeep Bhaskar Maheema Karimundackal George Jiwnani Sabita Shetmahajan Madhavi Pramesh C. S. 《Surgery today》2020,50(4):323-334
Surgery Today - Esophageal cancer surgery, comprising esophagectomy with radical lymphadenectomy, is a complex procedure associated with considerable morbidity and mortality. The enhanced recovery... 相似文献
47.
Nadeem Siddiqui Md. Jawaid Akhtar M. Shahar Yar Priya Ahuja Waquar Ahsan Sharique Ahmed 《Medicinal chemistry research》2014,23(11):4915-4925
A series of 3-(4-substitutedphenyl)-N-(5-(4-substitutedphenyl-1,3,4-oxadiazol-2-yl)but-2-enamide were synthesized using pharmacophoric elements for in vivo anticonvulsant activity yielding two potent candidates (4d and 4j) in the Phase I and Phase II screening employing maximal electroshock seizure and subcutaneous pentylenetetrazole test having minimal neurotoxicity. Their Phase II screen depicted an increment of nearly 2–10 times for MES and 7–67 folds for scPTZ in the therapeutic index and protective index—the two mainstays in the drug discovery. 相似文献
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Sara E. Murray Priya R. Pathak Sarah C. Schaefer Herbert Chen Rebecca S. Sippel 《World journal of surgery》2014,38(3):542-548
Background
The aim of the present study was to investigate the incidence of sleep disturbance and insomnia in patients with primary hyperparathyroidism (PHPT), and to evaluate the effect of parathyroidectomy.Methods
A questionnaire was prospectively administered to adult patients with PHPT who underwent curative parathyroidectomy over an 11-month period. The questionnaire, administered preoperatively and 6 months postoperatively, included the Insomnia Severity Index (ISI) and eight additional questions regarding sleep pattern. Total ISI scores range from 0 to 28, with >7 signifying sleep difficulties and scores >14 indicating clinical insomnia.Results
Of 197 eligible patients undergoing parathyroidectomy for PHPT, 115 (58.3 %) completed the preoperative and postoperative questionnaires. The mean age was 60.0 ± 1.2 years and 80.0 % were women. Preoperatively, 72 patients (62.6 %) had sleep difficulties, and 29 patients (25.2 %) met the criteria for clinical insomnia. Clinicopathologic variables were not predictive of clinical insomnia. There was a significant reduction in mean ISI score after parathyroidectomy (10.3 ± 0.6 vs 6.2 ± 0.5, p < 0.0001). Postoperatively, 79 patients (68.7 %) had an improved ISI score. Of the 29 patients with preoperative clinical insomnia, 21 (72.4 %) had resolution after parathyroidectomy. Preoperative insomnia patients had an increase in total hours slept after parathyroidectomy (5.4 ± 0.3 vs 6.1 ± 0.3 h, p = 0.02), whereas both insomnia patients and non-insomnia patients had a decrease in the number of awakenings (3.7 ± 0.4 vs 1.9 ± 0.2 times, p = 0.0001).Conclusions
Sleep disturbances and insomnia are common in patients with PHPT, and the majority of patients will improve after curative parathyroidectomy. 相似文献49.
Graham Cocks Sarah Curran Priya Gami Dafe Uwanogho Aaron R. Jeffries Annie Kathuria Walter Lucchesi Victoria Wood Rosemary Dixon Caroline Ogilvie Thomas Steckler Jack Price 《Psychopharmacology》2014,231(6):1079-1088
Until now, models of psychiatric diseases have typically been animal models. Whether they were to be used to further understand the pathophysiology of the disorder, or as drug discovery tools, animal models have been the choice of preference in mimicking psychiatric disorders in an experimental setting. While there have been cellular models, they have generally been lacking in validity. This situation is changing with the advent of patient-specific induced pluripotent stem cells (iPSCs). In this article, we give a methodological evaluation of the current state of the iPS technology with reference to our own work in generating patient-specific iPSCs for the study of autistic spectrum disorder (ASD). In addition, we will give a broader perspective on the validity of this technology and to what extent it can be expected to complement animal models of ASD in the coming years. 相似文献
50.
Authors Priya Nambisan Donna Lamkin Carrie DeLong 《Online Journal of Public Health Informatics》2014,6(2)
Telemonitoring is being increasingly used to provide services to patients with
developmental disabilities in residential community settings. The objective of
this study is to assess the feasibility, benefits and challenges of using
telemonitoring for aging patients with developmental disabilities. We also
assess the benefits and challenges of telemonitoring for the caregivers of these
patients. Focus groups and questionnaire-based surveys were used to collect data
from patients and caregivers. The study found that telemonitoring was feasible
and beneficial for the aging with developmental disabilities, albeit for those
who are moderate to high functioning. It was not beneficial or feasible for
those with very low functional capabilities. The study found that telemonitoring
was beneficial towards providing more independence, more self-confidence in
carrying out daily activities, and more knowledge regarding their disease. The
study also found that telemonitoring was useful for caregivers to better
understand their patients and their needs, better coordinate the services
delivered, and to enhance the satisfaction of caregiving. The discussions
include limitations of using quantitative methods in this type of setting. 相似文献