全文获取类型
收费全文 | 964篇 |
免费 | 43篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 21篇 |
妇产科学 | 27篇 |
基础医学 | 50篇 |
口腔科学 | 21篇 |
临床医学 | 85篇 |
内科学 | 119篇 |
皮肤病学 | 8篇 |
神经病学 | 31篇 |
特种医学 | 175篇 |
外科学 | 216篇 |
综合类 | 22篇 |
预防医学 | 37篇 |
药学 | 51篇 |
中国医学 | 1篇 |
肿瘤学 | 186篇 |
出版年
2023年 | 3篇 |
2021年 | 5篇 |
2020年 | 5篇 |
2018年 | 5篇 |
2017年 | 9篇 |
2016年 | 10篇 |
2015年 | 35篇 |
2014年 | 44篇 |
2013年 | 76篇 |
2012年 | 55篇 |
2011年 | 20篇 |
2010年 | 31篇 |
2009年 | 36篇 |
2008年 | 32篇 |
2007年 | 76篇 |
2006年 | 34篇 |
2005年 | 36篇 |
2004年 | 26篇 |
2003年 | 43篇 |
2002年 | 35篇 |
2001年 | 39篇 |
2000年 | 31篇 |
1999年 | 29篇 |
1998年 | 26篇 |
1997年 | 30篇 |
1996年 | 16篇 |
1995年 | 23篇 |
1994年 | 23篇 |
1993年 | 14篇 |
1992年 | 13篇 |
1991年 | 14篇 |
1990年 | 8篇 |
1989年 | 17篇 |
1988年 | 14篇 |
1987年 | 9篇 |
1986年 | 9篇 |
1985年 | 7篇 |
1984年 | 8篇 |
1983年 | 9篇 |
1982年 | 8篇 |
1981年 | 5篇 |
1980年 | 7篇 |
1976年 | 10篇 |
1975年 | 3篇 |
1971年 | 3篇 |
1968年 | 3篇 |
1949年 | 4篇 |
1948年 | 3篇 |
1947年 | 6篇 |
1908年 | 2篇 |
排序方式: 共有1054条查询结果,搜索用时 31 毫秒
51.
Ching-Wei D. Tzeng Matthew H. G. Katz Jason B. Fleming Jeffrey E. Lee Peter W. T. Pisters Holly M. Holmes Gauri R. Varadhachary Robert A. Wolff James L. Abbruzzese Jean-Nicolas Vauthey Thomas A. Aloia 《Journal of gastrointestinal surgery》2014,18(1):146-156
Background
We previously described the clinical classification of patients with resectable pancreatic tumor anatomy but marginal performance status (PS) or reversible comorbidities as “borderline resectable type C” (BR-C). This study was designed to analyze the incidence and risk factors for post-pancreaticoduodenectomy (PD) morbidity/mortality in a multi-institutional cohort of BR-C patients.Methods
Elective PDs were evaluated from the 2005-10 ACS-NSQIP database. BR-C was defined as age?≥?80, poor PS, weight loss?>?10 %, pulmonary disease, recent myocardial infarction/angina, stroke history, and/or preoperative sepsis. Variables associated with 30-day postoperative major complications (PMC) and mortality were analyzed.Results
A total of 3,033/8,266 (36.7 %) patients were BR-C. BR-C patients were more likely to suffer PMC (31.3 vs. 26.2 %) and mortality (4.1 vs. 2.3 %). BR-C patients with PMC suffered 50 % higher mortality versus non-BR-C patients with PMC (11.5 vs. 7.7 %) (all p?<?0.001). For BR-C patients, multivariate analysis identified the following risk factors for PMC or mortality: albumin?<?3.5 g/dL, dyspnea, preoperative sepsis, age?≥?80, poor PS, anesthesia score?≥?4, and intraoperative transfusion?≥?4 units.Conclusions
Nationwide, one third of patients undergoing PD are medically borderline. These BR-C patients are at higher risk for and less able to be rescued from PMC. Surgeons should identify and optimize comorbidities and utilize prehabilitation to address functional deficits before elective PD. 相似文献52.
Platelet-melanoma cell interaction is mediated by the glycoprotein IIb- IIIa complex 总被引:3,自引:0,他引:3
A human malignant melanoma cell line (M3Dau) was observed by electron microscopy to interact directly with human platelets and induced platelet aggregation. Fab fragments of a monoclonal antibody MoAb (LYP18), directed against the platelet glycoprotein (GP) IIb-IIIa complex, inhibited platelet-melanoma interactions and platelet-platelet aggregation. M3Dau melanoma cells bind LYP 18 and synthesize IIb-IIIa- like GPs. When the melanoma cells were preincubated with LYP 18, tumor- platelet interaction did not occur, suggesting that the interaction may be mediated by the IIb-IIIa-like GPs present on the melanoma cell surface. Glanzmann's thrombasthenic platelets, lacking GPIIb and IIIa, did not interact with melanoma cells, indicating that the platelet GPIIb-IIIa complex is also necessary for the platelet-melanoma cell interaction. This work demonstrates the importance of the IIb-IIIa-like GPs, present on M3Dau melanoma cells, in mediating tumor-platelet interactions. 相似文献
53.
LL Patton 《Oral diseases》2014,20(3):223-225
Over the last 30 years, there have been significant advances in our scientific knowledge of HIV disease, including prevention, detection, medical management, and attempts at cure. Investigations and observations of the oral cavity in individuals with HIV disease have contributed substantially to scientific discovery and innovation. Challenges remain for managing existing and emerging oral diseases associated with HIV and understanding the contribution of latent oral mucosal reservoirs to HIV eradication. 相似文献
54.
Badgwell B Cormier JN Xing Y Yao J Bose D Krishnan S Pisters P Feig B Mansfield P 《Annals of surgical oncology》2009,16(1):42-50
The purpose of this study was to determine the outcome of surgery for patients with recurrent gastric or gastroesophageal
cancer. We queried records from 7,459 patients who presented with gastric or gastroesophageal cancer to our institution from
1973 through 2005 to identify those for whom resection of recurrent disease had been attempted. We assessed the associations
between various clinicopathologic factors and resectability with logistic regression analysis and between clinicopathologic
factors and overall survival (OS) with the Cox proportional hazards model. Sixty patients underwent attempted resection for
recurrent cancer. In 31 cases (52%), recurrent disease proved unresectable at laparotomy. Factors associated with the ability
to undergo re-resection included neoadjuvant treatment prior to initial resection [odds ratio (OR) 12.2, 95% confidence interval
(CI) 1.9–75.6] and having an isolated local recurrence (OR 5.1, 95% CI 1.3–20.5). Of the 29 patients who underwent re-resection,
14 required adjacent organ resection, and 6 required interposition grafting. Three- and 5-year OS rates for all 60 patients
were 21% and 12%, respectively; median follow-up time was 23 months. Median OS for patients undergoing resection was 25.8 months
(95% CI 17.1–49.8) versus 6.0 months (95% CI 4.0–10.5) for unresectable patients (P < 0.001). Initial tumor location at the gastroesophageal junction was associated with diminished OS [hazard ratio (HR) 2.8,
95% CI 1.2–6.5] and ability to undergo resection of recurrence was associated with improved OS (HR 0.2, 95% CI 0.1–0.6). We
conclude that surgical resection of select patients with recurrent gastric or gastroesophageal cancer can result in improved
OS but often requires adjacent organ resection or interposition graft placement. 相似文献
55.
Effect of transforming growth factor-beta 1 on proliferation and induction of hemoglobin accumulation in K-562 cells 总被引:1,自引:1,他引:1
The effects of transforming growth factor-beta 1 (TGF-beta 1) on proliferation and hemoglobinization in K-562 cells, a human multipotential hematopoietic cell line, were studied. We found that TGF- beta 1 could induce hemoglobin accumulation in K-562 cells. Various clones were selected on the basis of the inducibility of hemoglobinization by TGF-beta 1. One high response clone (no. 1) and one low response clone (no. 8) were studied in detail. Hemoglobin accumulation peaked on day 5 of culture in the presence of TGF-beta 1 (0.5 ng/mL, 20 pmol/L), when 90% of clone 1 cells, 55% of parent line cells, and less than 10% of clone 8 cells contained hemoglobin. There was a concomitant reduction in proliferation of 60% for clone 1, 40% for the parent line, and 30% for the clone 8 on day 5 of culture. Quantitative analysis showed that the hemoglobin contents in clone 1 after 5-day induction by TGF-beta 1 and hemin were 1.0 pg/cell and 2.9 pg/cell, respectively. The hemoglobin induced by TGF-beta 1 showed the same electrophoretic characteristics as the hemoglobin induced by hemin. The expression of epsilon-globin mRNA was minimally detectable in control cells and was induced in both TGF-beta 1 and hemin treated cells. Other cytokines with potential effects on K-562 cell proliferation and differentiation were also studied. Interleukin-1, interleukin-3, interferon alpha, interferon gamma, and inhibin, tested as single agents, showed minimal effects on proliferation. None of these agents could induce hemoglobinization or inhibit the hemoglobinization induced by TGF-beta 1. 相似文献
56.
57.
58.
MSTM Almeida SCB Lima LL Carvalho JVM Almeida LG Santos JRA Rolim TE Rocha 《Journal of cutaneous pathology》2010,37(11):1170-1173
Systemic sclerosis (SSc) is an autoimmune systemic disease characterized by small vessel involvement that leads to tissue ischemia and fibroblast stimulation resulting in accumulation of collagen (fibrosis) in the skin and internal organs. Lipomembranous panniculitis is a peculiar type of fat necrosis and has been reported with clinical conditions, commonly with peripheral vascular diseases. We describe a case of a 43‐year‐old woman with SSc manifestations, who presented with black scaly skin plaques, associated with thickening of the subcutaneous fat tissue, on the lateral surface of her thighs, her calves, gluteal area and lower abdomen. Biopsy revealed lipomembranous panniculitis. Lipomembranous changes have been seen in connective tissue disorders such as lupus profundus, morphea, systemic sclerosis and panniculitis associated with dermatomyositis, but rarely in thighs, calves, gluteal area and lower abdomen. Almeida MSTM, Lima SCB, Carvalho LL, Almeida JVM, Santos LG, Rolim JRA, Rocha TE. Panniculitis–An unusual cutaneous manifestation of systemic sclerosis. 相似文献
59.
60.