肺癌患者血清与癌肿块中细胞因子的变化及其意义

目的：探讨肺癌患血清与癌肿块中白介素－8（IL－8），白介素－18（IL－18），肿瘤坏死因子（TNFα），血管细胞粘附因子－1（sVAM-1)的变化情况，方法：采用Elisa方法检测12例正常对照，17例肺癌患手术前后IL－8，IL－18，TNFα，sVCAM-1在血清和癌旁肺组织，癌组织中的含量。结果：肺癌患手术前后血清中的IL－8，IL－18，TNFα，sVCAM-1含量均比正常对照组增高有显差异（P值均＜0．01），术后与术前两组比较术后TNFα含量有明显下降（P＜0．05），其余3项指标有一定下降但无显差异，癌肿块中IL－8，IL－18，TNFα，sVCAM-1含量比癌旁组织中的含量4项指标均显增高（P＜0．01，P＜0．05），结论：测定血清中的IL－8，IL－18，TNFα，sVCAM-1对肺癌的诊断及判断预后，鉴别良，恶性肿瘤有重要临床意义。     

Severity of obstructive sleep apnea: correlation with clinical examination and patient perception.

OBJECTIVE: To correlate clinical history, patient self-perception of obstructive sleep apnea, and physical examination with the severity of OSA. METHODS: One hundred and two consecutive patients were prospectively enrolled over a 6-month period. All patients underwent a comprehensive history and clinical examination, nasopharyngoscopy, and an overnight-attended polysomnogram. RESULTS: There were 65 males and 37 females with a mean age of 50.2 +/- 11.3 years (range, 24 to 76 years). The mean apnea-hypopnea index (AHI) was 37.9 +/- 27.7 (range, 0.7 to 111.2). There was a strong correlation between patient self-perception of OSA severity and AHI (r = 0.499, P < 0.0001), and the correlation with AI was 0.577 (P < 0.0001). OSA severity strongly correlated with Friedman Tongue Position grade, (r = 0.389, P < 0.0001), Friedman clinical staging, (r = 0.331, P = 0.0007). Of significance, only 6.9% of patients with mild OSA had a >50% collapse of the base of tongue region, as compared to 65.9% of patients with severe OSA. CONCLUSION: There is good correlation between clinical examination parameters and the severity of OSA. An algorithm for surgical treatment of OSA should acknowledge both the site of obstruction and the severity of disease.     

Poems syndrome.

A 40 year old Chinese woman presented with anasarca and later developed features of POEMS syndrome. These are peripheral neuropathy (P), organomegaly (O), endocrine dysfunction (E), monoclonal gammopathy (M), and skin changes (S) which are usually associated with plasma cell dyscrasia. In our patient, monoclonal gammopathy was not detected on immunofixation electrophoresis and was revealed only after analysis of kappa/lambda light chain ratio of the raised serum IgA immunoglobulin. Needle liver biopsy of her grossly enlarged liver showed marked accumulation of glycogen and presence of giant mitochondria in the hepatocytes, a feature not previously reported.     

郑州市1987至1989年蚊虫密度监测报告

本文报道了郑州市蚊虫三年监测结果,总体密度(只/人工小时)为54.5,其中住房为40.2,牲畜房为68.8,后者明显高于前者。年平均密度,住房1987～39年分别为41.7、36.6和42.1;牲畜房三年分别为84.4、69.7和52.3。虽三年中大气候无明显变化,但由于稻田、藕池面积逐渐减少,使蚊虫密度呈逐年下降趋势。实践证明,蚊虫监测工作对蚊媒传染病的防治和监测,具有重要的流行病学意义。     

Histochemical study of human nasal mucosa

The histochemical study of the fetal nasal mucosa collected from fetus of different months is reported. The concentration of succinic dehydrogenase and acid phosphatase in nasal epithelium kept pace with the fetal growth which explained a steady improving metabolism and secretory activity of the fetal nasal mucosa. On the other hand, activities of alkaline phosphatase in the mesenchymal cells, the fibroblasts and the glandular cells were getting weaker and weaker indicating the functional maturation of the fetal nasal mucosa. During the sixth month, mucins occur red in the glands, which showed the establishment of the secretory function in the nasal mucous glands.     

The Capacity of Lymphokine Production by Peripheral Blood Lymphocytes from Aged Humans

The functional capability to produce interleukin 2 (IL2) and interferon gamma (IFNγ) by peripheral blood lymphocytes (PBL) from elderly humans was evaluated. Thirty-nine samples of PBL derived from donors aged from 56 to 79 yr were cultured with phytohaemagglutinin (PHA) as stimulus at 37°C for 48 hours. The IL2 activity in the supernatants was measured by its ability to sustain the IL2-dependent CTLL growth. Cultures of elder human T cells produced low level of IL2 activity, that is on the average of 9.7±9.8 μ/ml, equivalent to 28.1% the IL2 activity in parallel cultures of PBL derived from young donors (34.2±8.3 μ/ml, assessed on the basis of 145 samples). In the elder humans, the IL2 production by PBL decreased progressively as the increase of the age of the donors.

In contrast to the impairment of IL2 production, the amount of IFNγ secretion by elder human T cells was almost at the same level as that by young human T cells. The average IFNγ activity of 39 samples of elder PBL cultures and 128 samples of young PBL cultures was 2,961±736 μ/ml and 3133±950 μ/ml, respectively.

There was no significantly positive correlation between the level of IL2 and IFNγ when comparison was made based on each individual samples. This implies that it may exist an alternative way of IFNγ production which does not require the induction by IL2, and the relatively high level of IFNγ may not impose adverse effect on the IL2 production.     

眼睑恶性肿瘤的组织学控制性切除

报告眼脸恶性肿瘤81例进行组织学控制切除;20例进行单纯性切除。追踪结果显示:组织学控制切除之复发率比单纯切除明显降低,且能保存更多健康眼睑组织,有利于它的重建成形。肿瘤边缘与切除的最适宜距离在睑板腺癌为6～10毫米,在基底细胞癌为3～5毫米。     

褐稻虱自然种群生命表的组建方法

本文把褐稻虱种群按其生长发育顺序划分为卵（E）、1－2龄若虫（S）、3－4龄若虫（L）和成虫（A）4个阶段，把各阶段的作因子划分为相对独立的状态（staltes)，在稻田调查中分别记录其单位面积的数量。通过换算，计算卵、1－2龄若虫和3－5龄若虫的存活率（Sg,Ss,Sl)及各作用因子相对应的存活率（S1，S2，S3，S4，S5，S6），同时通过实验种群的产卵量（FPfP），成虫逐日产卵概率（Pn)和自然种群成虫逐日存活率（AAa)组成的下代卵量概率，∑Pfl(SAa)′组成褐稻虱自然种群生命表的各个组分，如果包含成虫迁移后的居留率St,则根据生命表组分建立的种群趋势数字模型(Morris-Watt种群数学模型^[7,10,11])可扩充为：I＝SESSSLFPFP♂St∑Pfl(SAa)协′I＝S1S2S3S4S5S6FPFP♀St∑Pfl(SAa)′。     

遗传性球形红细胞增多症红细胞膜收缩蛋白的改变

分析１５例遗传性球形红细胞增多症患者膜收缩蛋白的变化，其中３例膜收缩蛋白部分缺失；３例膜收缩蛋白四聚体减少；９例既有膜收缩蛋白缺失，还存在四聚体减少。对其中１例患者进行了透射电镜观察。