全文获取类型
收费全文 | 1278660篇 |
免费 | 98055篇 |
国内免费 | 1992篇 |
专业分类
耳鼻咽喉 | 18442篇 |
儿科学 | 44359篇 |
妇产科学 | 35008篇 |
基础医学 | 182193篇 |
口腔科学 | 33593篇 |
临床医学 | 111255篇 |
内科学 | 258244篇 |
皮肤病学 | 28024篇 |
神经病学 | 100369篇 |
特种医学 | 51200篇 |
外国民族医学 | 660篇 |
外科学 | 196390篇 |
综合类 | 27082篇 |
现状与发展 | 1篇 |
一般理论 | 377篇 |
预防医学 | 95729篇 |
眼科学 | 27912篇 |
药学 | 94778篇 |
2篇 | |
中国医学 | 2427篇 |
肿瘤学 | 70662篇 |
出版年
2018年 | 13135篇 |
2017年 | 9965篇 |
2016年 | 10897篇 |
2015年 | 12380篇 |
2014年 | 17171篇 |
2013年 | 26214篇 |
2012年 | 36029篇 |
2011年 | 38056篇 |
2010年 | 22806篇 |
2009年 | 21809篇 |
2008年 | 36638篇 |
2007年 | 39250篇 |
2006年 | 39509篇 |
2005年 | 38452篇 |
2004年 | 37599篇 |
2003年 | 36458篇 |
2002年 | 35798篇 |
2001年 | 63995篇 |
2000年 | 66498篇 |
1999年 | 56411篇 |
1998年 | 15133篇 |
1997年 | 13759篇 |
1996年 | 14201篇 |
1995年 | 13456篇 |
1994年 | 12769篇 |
1993年 | 11793篇 |
1992年 | 44559篇 |
1991年 | 43467篇 |
1990年 | 42222篇 |
1989年 | 40118篇 |
1988年 | 36903篇 |
1987年 | 36241篇 |
1986年 | 33622篇 |
1985年 | 32283篇 |
1984年 | 24139篇 |
1983年 | 20272篇 |
1982年 | 11726篇 |
1981年 | 10692篇 |
1980年 | 9518篇 |
1979年 | 21343篇 |
1978年 | 14822篇 |
1977年 | 12534篇 |
1976年 | 11693篇 |
1975年 | 12625篇 |
1974年 | 14662篇 |
1973年 | 14117篇 |
1972年 | 12944篇 |
1971年 | 11729篇 |
1970年 | 11050篇 |
1969年 | 10024篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
191.
192.
A. Heinig S. H. Heywang-Köbrunner P. Viehweg D. Lampe J. Buchmann R. P. Spielmann 《Der Radiologe》1997,37(9):710-717
Summary
Early recognition of recurrence and work-up of clinically indeterminate lesions may be impaired after reconstruction with
silicone implants due to superimposition of the implant or to scarring. This study was undertaken to evaluate the use of contrast-enhanced
MRI in patients with silicone implant after breast cancer. Contrast-enhanded MRI was offered to 169 patients. Comparative
two- to three-view mammography was also performed in 169 patients, as well as comparative sonography in 144 patients. Conventional
imaging and clinical examination detected only 8/13 recurrences, whereas 12/13 were detected by MRI. One recurrence had been
visible as a strongly enhancing 2-mm dot in a previous examination (2 years before), but was not called. It was therefore
counted as false negative. In addition, multicentricity was detected by MRI alone in two of three cases. MRI correctly diagnosed
scar tissue in all cases with indeterminate findings. However, due to false-positive calls caused by enhancing granulomas
specificity could not be improved. Contrast-enhanded MRI allowed decisive additional information in our study group and improved
the sensitivity significantly (concerning all diagnoses). Contrast-enhanded MRI is recommended in patients with diagnostic
problems or high risk of recurrence after silicone implants.
相似文献
193.
T. Schneider W. Menke B. Fink W. Rüther K. P. Schulitz 《Archives of orthopaedic and trauma surgery》1997,116(1-2):46-49
In this study 17 patients with recurrent dislocation of the patella were followed up 10 years after their Goldthwait operation. The subjective and clinical findings were excellent or good in 70%. X-radiographs indicated osteoarthritis of the femoropatellar joint in 60%. Concerning the aetiopathological factors, we found an increased external torsion of the afflicted extremity (measured by computed tomography). 相似文献
194.
The pulsed tunable dye laser (PTDL) is generally considered to have a very low incidence of adverse effects, allowing it to become the treatment of choice for the majority of port wine stains (PWS). The low incidence of adverse effects has led to difficulties in determining the true incidence and type of adverse effect seen with this laser. We therefore undertook a retrospective study of 701 patients with PWS, who received 3877 full treatments to determine the incidence and type of adverse effects seen following treatment with the PTDL. Blistering and crusting were seen in 5·9% and 0·7% of patients, respectively, but were transient events which usually healed without permanent sequelae. Hyperpigmentation was the most frequently observed adverse effect seen in 9·1% of patients but generally showed gradual resolution over 6–12 months. Hypopigmentation was infrequent, seen in 1.4% of patients. The most significant adverse effects were atrophic and hypertrophic scarring seen in 4·3% and 0·7% of patients, respectively. Our observations show that there is a small but definite risk of atrophic scarring with a predisposition for younger patients. Hypertrophic scarring can occur albeit rarely and there may be a predisposition towards the neck. In most cases test areas were not predictive of scarring. This underlines the need for a full discussion of scarring risk in patients with PWS undergoing treatment with the PTDL. 相似文献
195.
Bullous pemphigoid in association with cutaneous lesions specific to a myelodysplastic syndrome 总被引:1,自引:0,他引:1
P. MODIANO S. REICHERT A. BARBAUD P. BERNARD† M. WEBER J.L. SCHMUTZ 《The British journal of dermatology》1997,136(3):402-405
Specific cutaneous lesions are a rare occurrence in myelodysplastic syndromes (MDS). The concurrent association of blistering skin lesions similar to those in bullous pemphigoid (BP), even though a rare event, suggests that BP may be a paraneoplastic syndrome. We report an 86-year-old man who had a refractory anaemia with excess bone marrow blasts in transformation, who developed a generalized pruritic blistering eruption. Immunohistopathological tests showed subepidermal blisters with linear deposits of IgG and C3 along the basement membrane zone of the epidermis surrounding a tumoral dermal infiltrate of CD13+ and CD15+ cells. Immunoblotting studies using epidermal extracts revealed circulating IgG antibodies against three protein bands: a 210–215 kDa band. a 180kDa band which co-migrated with the BP 180 antigen, and a 190kDa band. The tumour infiltrate may have revealed antigenic determinants which led to the onset of BP. The concept of paraneoplastic pemphigoid remains to be either confirmed or invalidated by further epidemiological studies. 相似文献
196.
The objective of this article is to describe various radiographic projections which can be used during endodontic therapy. Changes to the angulation of the X-ray beam in relation to the teeth and film can help diagnosis and treatment by producing images which provide additional information not always visible on radiographs taken with standard angulations. For example, changes in angulation can be useful to determine the number and curvature of roots and canals, to identify superimposed roots and to distinguish between anatomical landmarks and apical pathology. Although use of such techniques increases the diagnostic yield of films, it must be appreciated that such views lead to images that are less distinct because of inherent image distortion. Nevertheless, use of the various techniques during endodontics can provide substantial benefit for clinicians in their daily practice. 相似文献
197.
M. A. García-Pérez C. Climent P. Briones M. A. Vilaseca M. Rodés V. Rubio 《Journal of inherited metabolic disease》1997,20(6):769-777
Mutations P225L and P225R were identified in codon 225 of the gene for ornithine transcarbamylase (OTC) in two patients with the neonatal form of OTC deficiency. The mutations occur at a CpG dinucleotide and eliminate a unique MspI restriction site in exon 7 of the OTC gene. They do not alter existing splice sites or create new sites, as judged from the nucleotide sequence. Both mutations are associated with undetectable levels of OTC antigen in liver homogenates, and with either complete lack of OTC activity (P225R mutation) or very small residual activity (0.15% of normal in the P225L mutation). The residual activity observed with P225L exhibits normal pH dependence, little or no increases in the Km values for ornithine and carbamoyl phosphate and normal stability at either 37°C or, in the presence of 0.66 mol/L urea, at 0°C. The latter conditions were used to examine whether the P225L mutation favours dissociation of the active OTC trimer. Given the normal stability and lack of tendency to dissociation of the mutant enzyme, it appears likely that the dramatic reduction in the level of OTC protein is due to inefficient conversion of the mutant OTC precursor polypeptide (pOTC) into the correctly localized, appropriately folded, mature enzyme trimer, suggesting degradation of pOTC in transit to the mitochondria. 相似文献
198.
199.
A 60-year-old man developed hemiballismus due to an intracranial hemorrhage involving the subthalamic nucleus 8 weeks after orthotopic liver transplantation. The hemorrhage was thought to be due to alterations in cerebral blood flow following a period of hypotensive shock due to sepsis, in the presence of anticoagulant therapy and thrombocytopenia. This represents a rare neurologic complication of liver transplantation. 相似文献
200.
Paul P. W. van Buul Iris M. Zandman Mira Grigorova Jan J. W. A. Boei Adayapalam T. Natarajan 《Chromosome research》1995,3(7):427-432
The efficiency of two methods of detection of translocations induced in mouse stem cell spermatogonia by X-ray doses of 2, 5 and 7 Gy was compared: classical multivalent analysis at diakinesis-metaphase I of meiosis and observation via fluorescencein situ hybridization analysis of mitotic or meiotic stages. Specific DNA libraries for chromosomes 1, 11 and 13 were used. The results obtained indicate that (a) chromosomes 1, 11 and 13 are more involved in multivalent formation than expected on the basis of DNA content and (b) if the mitotic FISH analysis data are corrected for the observed over-representation, the frequencies of induced translocations are similar to those recorded in the classical multivalent studies, suggesting equal scoring efficiencies in both systems. 相似文献