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71.
Kuo-Chung Lan Hsin-Ju Chiang Tiao-Lai Huang Yu-Jie Chiou Te-Yao Hsu Yu-Che Ou Yao-Hsu Yang 《Journal of assisted reproduction and genetics》2021,38(1):85
PurposeTo study the association between paternal age and schizophrenia in offspring.MethodsThis report describes a nationwide population-based cohort study from 1997 to 2013. Data from Taiwan’s National Health Insurance Research Database were utilized to answer the research question. A total of 17,649 offspring with schizophrenia were selected from 11 million offspring in the general population. Additionally, we established the offspring without schizophrenia as the comparison group by matching the study cohort by age, gender in a 1:4 ratio (n = 70,596).ResultsThe median age at first presentation with schizophrenia was 20 years (interquartile range (IQR), 17 to 24). Comparison of the schizophrenia and non-schizophrenia groups indicated that father’s age at birth (30.0 (IQR), 27 to 33 vs. 29.0 (IQR), 26 to 32 years), mother’s age at birth (26.0 (IQR), 24 to 29 vs. 26.0 (IQR), 23 to 29 years), paternal schizophrenia (2.6% vs. 0.6%), and maternal schizophrenia (4.4% vs. 0.7%) were all significantly greater in the schizophrenia group. In addition, each 5-year increase in father’s age increased the odds of being diagnosed with schizophrenia (model 1: aOR = 1.22; 95% CI 1.20, 1.24; model 2: aOR = 1.20; 95% CI 1.18, 1.23). Subgroup analysis showed that each 5-year increase in father’s age increased the odds of being diagnosed with schizophrenia in male and female offspring, as well as in offspring of mothers and fathers with or without schizophrenia (aOR = 1.20 to 2.20, all p values < 0.01).ConclusionThis study indicated that advanced paternal age increased the risk of schizophrenia in offspring. Offspring born to fathers older by 5-year increments were at heightened risk of schizophrenia. 相似文献
72.
目的:观察头皮针联合康复训练对脑卒中后轻度认知障碍患者血管内皮功能及脑血流动力学的影响。方法:选取2011年3月至2017年3月辽宁中医药大学附属第二医院收治并确诊为脑卒中(缺血性脑梗死与脑出血)后合并轻度认知障碍的患者100例,按照入选的先后顺序分为观察组与对照组,每组50例,对照组给予常规药物治疗与康复训练治疗,观察组在对照组基础上给予头皮针治疗,连续治疗3个月。治疗前与治疗过程中(2周、1个月、3个月)比较2组脑循环参数[经颅多普勒超声(TCD)测量双侧椎动脉(VA)、大脑中动脉(MCA)、大脑前动脉(ACA)阻力指数(RI)]、血管内皮功能[血清一氧化氮(NO)、内皮素-1(ET-1)]的变化。结果:治疗后2组的双侧VA、MCA、ACA的RI均低于治疗前,差异有统计学意义(P 0. 05),且治疗后各时间点观察组低于对照组,差异有统计学意义(P 0. 05);治疗过程中(2周、1个月、3个月) 2组的血清NO均高于治疗前,差异有统计学意义(P 0. 05),且治疗后各时间点观察组高于对照组,差异有统计学意义(P 0. 05),治疗后2组的血清ET-1均低于治疗前,差异有统计学意义(P 0. 05),且治疗后各时间点观察组低于对照组,差异有统计学意义(P 0. 05)。结论:头皮针结合康复训练能通过改善脑卒中后合并轻度认知障碍患者的血管内皮功能而调节血流动力学。 相似文献
73.
目的:探讨冠心病经皮冠状动脉介入术(PCI)术后双联抗血小板治疗中消化道大出血的相关危险因素。方法:收集湖南省人民医院2015年1月~2020年12月冠心病PCI术后患者1335例为研究对象,因消化道大出血再入院患者46例(占3.4%),纳入消化道大出血组;无消化道出血者1289例(占96.6%)用等距随机抽样法选出50例作为对照组。比较两组患者的性别、年龄、肾功能、低蛋白血症、糖尿病史、高血压史、高脂血症、吸烟史、饮酒史、联合口服PPI、血管病变支数等相关情况,探讨冠心病双联抗血小板治疗中消化道大出血的相关危险因素。结果:单因素logistic回归分析显示PCI术后消化道大出血组年龄≥65岁、肾功能异常、低蛋白血症、吸烟史占比高于对照组,联合口服PPI占比低于对照组。差异具有统计学意义,出血组与对照组在性别、高血压史、糖尿病史、饮酒史、血管病变支数病史两组比较差异无统计学意义。多因素logistic回归分析显示低蛋白血症是消化道大出血的独立危险因素。结论:高龄、肾功能异常、低蛋白血症、吸烟史等是PCI术后双联抗血小板导致消化道大出血的危险因素,尤其低蛋白血症是消化道大出血的独立危险因... 相似文献
74.
75.
目的探讨急性冠状动脉综合征(ACS)患者中医辨证分型与冠状动脉病变的关系及对短期预后的影响。方法252例ACS患者根据中医辨证分型分为4组:D血瘀阻证组(178例)、气阴两虚证组(50例)、心肾阴虚证组(14例)和痰阻心脉证组(10例)。经冠状动脉造影明确冠状动脉病变,分析不同证型对住院期间和短期预后的影响。结果252例患者中,三支和二支病变者182例(72.2%),B型和C型病变214例(85.0%),左主干病变44例(17.5%),慢性完全闭塞病变68例(27.0%)。痰阻心脉证组(10例)、心血瘀阻证组(178例)、心肾阴虚证组(14例)、气阴两虚证组(50例)患者SYNTAX评分分别为(33.2±2.0)、(29.7±2.3)、(27.6±1.9)、(28.5±2.5)分,痰阻心脉证组SYNTAX评分明显高于心肾阴虚证组及气阴两虚证组,差异有统计学意义(P〈0.05)。痰阻一tk,脉证组三支病变(7/10)、左主干病变(5/10)、慢性完全闭塞性病变(4/10)、c型病变(9/10)比例均明显高于其他3组,差异有统计学意义(P〈0.05)。住院期间4组均无主要心血管不良事件(MACE)发生。随访半年时痰阻心脉证组MACE发生率(3/10)高于心血瘀阻证组[3.9%(7/178)]、气阴两虚证组[4.0%(2/50)]和心肾阴虚证组(0)。结论ACS主要中医证型为心血瘀阻证。尽管痰阻心脉证患者较少,但冠状动脉SYNTAX积分高,病变高危复杂,短期预后较差,临床上应该高度重视这一证型的患者,及早行冠状动脉检查以明确病变并规范治疗。 相似文献
76.
目的建立测定血浆及膀胱组织中阿霉素含量的反相高效液相色谱法。初步应用于膀胱癌患者膀胱内灌注阿霉素预防膀胱肿瘤术后复发的疗效观察。方法血浆中样品用二氯甲烷-异丙醇混合液提取,膀胱组织制成匀浆后经二氯甲烷-异丙醇混合液提取,Hypersil ODS柱(4.6 mm×200 mm,10μm)为分析柱,甲醇-0.01 mol.L-1磷酸二氢钾-冰醋酸(85∶15∶0.5)为流动相,检测波长为E4X75 nm、E54M5 nm,以柔红霉素为内标。结果血浆及膀胱组织中阿霉素的线性范围分别为10~300 ng.ml-1和0.1~1.0μg.g-1,日内、日间误差RSD均小于10%,平均回收率分别为104.39%和94.52%。结论本法测定血浆及膀胱组织中阿霉素含量准确、简便,适用于阿霉素药代动力学的研究。 相似文献
77.
洛美沙星体内外抗菌活性研究 总被引:5,自引:0,他引:5
洛美沙星对革兰氏阴性菌具有强的抑菌活力。对克氏肺炎杆菌的抗菌活性最强,MIC_(50)为0.12mg/L;对痢疾杆菌、产气杆菌、粘质沙雷氏菌、不动杆菌和枸椽酸杆菌的MIC_(50)分别为1和4mg/L。洛美沙星对肠细菌科细菌的活力比诺氟沙星和依诺沙星强2~16倍,明显地比丁胺卡那霉素、庆大霉素强。对金葡球菌MIC_(50)为1mg/L, MRSA对洛美沙星同样敏感。洛美沙星对表葡球菌、链球菌、粪链球菌及肺炎双球菌等的抗菌活性与地氟沙星相似,比诺氟沙星、依诺沙星、丁胺卡那霉素、庆大霉素和头孢三嗪分别强2~4倍。 洛美沙星对小鼠全身感染的疗效优于诺氟沙星。对大肠杆菌、克氏肺炎杆菌和绿脓杆菌感染小鼠iv的ED_(50)分别是0.74、0.13和3.45mg/kg, po的ED_(50)分别是0.94、1.46和6.20mg/kg。 相似文献
78.
盐酸雷尼替丁泡腾颗粒剂的生物等效性研究 总被引:3,自引:0,他引:3
目的:测定盐酸雷尼替丁泡腾颗粒剂的生物等效性。方法:10名男性健康志愿者交叉口服盐酸雷尼替丁泡腾颗粒剂和盐酸雷尼替丁胶囊,采用HPLC法测定人血清中药物浓度进行生物等效性的研究。以ALLTMA C18为固定相,0.02mol·L-1磷酸二氢钾溶液-甲醇(70:30)为流动相,流速1.0mL·min-1,检测波长为320nm。结果:泡腾颗粒剂与胶囊的血药浓度曲线均符合二室模型。其主要药物动力学参数:Tpeak分别为(1.96±0.55)h和(2.21±0.39)h,Cmax分别为(665±213)μg·L-1和(547±181)μg·L-1,AUC分别为(3452±601)h·μg·L-1和(3053±579)h·μg·L-1。各参数经配对t-检验处理,均无显著差异(P>0.05),泡腾颗粒剂的生物等效性经含量校正后为108%。结论:结果表明泡腾颗粒剂与胶囊剂具有生物利用等效性。 相似文献
79.
Yan Sun Rashmi Supriya Yang Gao Dan Tao Siyue Yu Aiwei Wang Hardaway Chun-Kwan Chan Xiaoting Ou Jingjing Wang Julien S. Baker 《Nutrients》2022,14(15)
To investigate the prevalence of hypertension and associated risk factors in Chinese children with intellectual disability, a cross-sectional study was conducted in a sample of 558 children with intellectual disability aged 6–18 years in Hong Kong, and 452 (81.0%) with valid data were included in the data analysis. Blood pressure was measured according to a standard protocol. Hypertension was defined using the age-, gender-, and height-specific classification criteria recommended by the 2018 Chinese Guidelines for Children. Multivariate and hierarchical logistic regression was fitted to examine the associations of hypertension with potential risk factors. Overall, 31.4% of the participants were classified as having hypertension. Obese children were more likely to develop hypertension than non-obese children (adjusted OR = 2.77, 95% CI: 1.28, 5.99, p = 0.010). A paternal education of college or above and a paternal occupation of clerks, sales representatives, and workers were also associated with an increased risk of hypertension. The prevalence of hypertension is high among Chinese children with intellectual disability. Obesity was the strongest risk factor. Further longitudinal studies are warranted to confirm our findings. Nevertheless, preventions against obesity are promising to receive doubled benefits in reducing both obesity and hypertension, given its strong relationship with hypertension in this special population. 相似文献
80.
Background:The efficacy of alfentanil supplementation for the sedation of bronchoscopy remains controversial. We conduct a systematic review and meta-analysis to explore the influence of alfentanil supplementation on the sedation during bronchoscopy.Methods:We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through December 2019 for randomized controlled trials (RCTs) assessing the effect of alfentanil supplementation versus placebo for the sedation during bronchoscopy. This meta-analysis is performed using the random-effect model.Results:Five RCTs are included in the meta-analysis. Overall, compared with control group for bronchoscopy, alfentanyl supplementation is associated with significantly reduced coughing scores (Std. MD = –0.55; 95% CI = –0.96 to –0.14; P = 0.009) and dose of propofol (Std. MD = –0.34; 95% CI = –0.64 to –0.04; P = 0.03), but reveals the increase in hypoxemia (RR = 1.56; 95% CI = 1.17 to 2.08; P = 0.002).Conclusions:Alfentanyl supplementation benefits to reduce coughing scores and dose of propofol for bronchoscopy, but increases the incidence of hypoxemia. The use of alfentanyl supplementation for bronchoscopy should be with caution. 相似文献