全文获取类型
收费全文 | 1253篇 |
免费 | 80篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 46篇 |
妇产科学 | 60篇 |
基础医学 | 138篇 |
口腔科学 | 43篇 |
临床医学 | 96篇 |
内科学 | 253篇 |
皮肤病学 | 17篇 |
神经病学 | 44篇 |
特种医学 | 39篇 |
外科学 | 272篇 |
综合类 | 37篇 |
一般理论 | 1篇 |
预防医学 | 76篇 |
眼科学 | 13篇 |
药学 | 101篇 |
中国医学 | 8篇 |
肿瘤学 | 89篇 |
出版年
2023年 | 14篇 |
2022年 | 37篇 |
2021年 | 45篇 |
2020年 | 28篇 |
2019年 | 44篇 |
2018年 | 46篇 |
2017年 | 31篇 |
2016年 | 24篇 |
2015年 | 38篇 |
2014年 | 40篇 |
2013年 | 55篇 |
2012年 | 74篇 |
2011年 | 76篇 |
2010年 | 56篇 |
2009年 | 39篇 |
2008年 | 62篇 |
2007年 | 72篇 |
2006年 | 74篇 |
2005年 | 54篇 |
2004年 | 52篇 |
2003年 | 39篇 |
2002年 | 52篇 |
2001年 | 23篇 |
2000年 | 22篇 |
1999年 | 20篇 |
1998年 | 15篇 |
1997年 | 8篇 |
1996年 | 4篇 |
1995年 | 11篇 |
1994年 | 13篇 |
1993年 | 7篇 |
1992年 | 16篇 |
1991年 | 10篇 |
1990年 | 18篇 |
1989年 | 15篇 |
1988年 | 19篇 |
1987年 | 8篇 |
1986年 | 7篇 |
1985年 | 10篇 |
1983年 | 7篇 |
1982年 | 6篇 |
1980年 | 5篇 |
1979年 | 3篇 |
1976年 | 3篇 |
1974年 | 3篇 |
1972年 | 3篇 |
1971年 | 3篇 |
1969年 | 4篇 |
1967年 | 3篇 |
1966年 | 3篇 |
排序方式: 共有1338条查询结果,搜索用时 234 毫秒
51.
Ahmed S Nanda NC Miller AP Nekkanti R Yousif AM Pacifico AD Kirklin JK McGiffin DC 《Echocardiography (Mount Kisco, N.Y.)》2003,20(2):203-209
We evaluated the potential usefulness of three-dimensional (3D) transesophageal echocardiography (TEE) in assessing individual scallop/segment prolapse in 36 adult patients with mitral valve prolapse (MVP) undergoing surgical correction. Intraoperative 3D TEE correctly identified the location of scallop/segment prolapse in 34 of 36 patients (94%). However, in 6 of these patients 3D TEE images revealed more scallops or segments with prolapse than the surgeon noted intraoperatively. Prolapse of these areas was less prominent and this could possibly explain the lack of correlation with the surgical findings in these patients. In another 2 patients areas of prolapse seen by the surgeon were missed by 3D TEE because some of those scallops/segments could not be well imaged due to image "drop out" and artifacts. Thus, perfect correlation between 3D TEE and surgery was noted in 28 of 36 (78%) patients. Noncoaptation of the MV was also identified in 2 patients. The prolapsed area of posterior (n = 28 observations) and anterior (n = 9 observations) MV leaflets ranged from 1 cm2 to 9 cm2 (mean 3.50 cm2+/- 2.14) and 1.20 cm2 to 5.99 cm2 (mean 3.21 cm2+/- 1.33), respectively. Interobserver and intraobserver agreement for location and area of MVP was excellent (r = 0.97 and r = 0.99, respectively; all P values are <0.0001). In conclusion, 3D TEE is useful in identifying the location of MVP. It may also be potentially useful in assessing the extent of individual scallop/segment prolapse and identifying sites of MV noncoaptation. This information could aid the surgeon in deciding the extent of MV resection. 相似文献
52.
Synchronous splenectomy during cholecystectomy for hereditary spherocytosis: Is it really necessary?
Raaj K. Ruparel James N. Bogert Christopher R. Moir Michael B. Ishitani Shakila P. Khan Vilmarie Rodriguez Abdalla E. Zarroug 《Journal of pediatric surgery》2014
Background/Purpose
Expert guidelines recommend performing synchronous splenectomy in patients with mild hereditary spherocytosis (HS) and symptoms of gallstone disease. This recommendation has not been widely explored in the literature. The aim of this study is to determine if our data support expert opinion and if different practice patterns should exist.Methods
This is an IRB-approved retrospective study. All HS patients under 18 years of age who underwent cholecystectomy for symptomatic gallstones at a single institution between 1981 and 2009 were identified. Patients who underwent cholecystectomy without concurrent splenectomy were reviewed retrospectively for future need for splenectomy and evidence of recurrent gallstone disease.Results
Of the 32 patients identified, 27 underwent synchronous splenectomy. The remaining 5 patients underwent cholecystectomy without splenectomy and had a mean age of 9.4 years. One of the 5 patients eventually required splenectomy for left upper quadrant pain. None of the remaining 4 required hospitalization for symptoms related to hemolysis or hepatobiliary disease. Median follow-up is 15.6 years.Conclusion
The need for splenectomy in patients with mild HS and symptomatic cholelithiasis should be assessed on a case by case basis. Our recommendation is to not perform synchronous splenectomy in conjunction with cholecystectomy for these patients if no indication for splenectomy exists. 相似文献53.
Abdalla Henrique Ballassini Clemente-Napimoga Juliana Trindade Bonfante Ricardo Hashizume Caio Augusto Zanelli Wilian Segatto de Macedo Cristina Gomes Napimoga Marcelo Henrique Buarque e Silva Wilkens Aurélio Andrade e Silva Frederico 《Clinical oral investigations》2019,23(4):1905-1912
Clinical Oral Investigations - The goal of this study is to propose a standard protocol of experimental occlusal trauma to evaluate the inflammatory hyperalgesia induced by metallic crowns on... 相似文献
54.
Infant oral mutilation is the practice of removing developing tooth germs, commonly the mandibular canine, in infants up to the age of 1 year. Subsequent complications include missing, impacted or hypoplastic permanent anterior and canine teeth. We report on a case of bilaterally missing lower canines thought to be due to infant oral mutilation. It is important that general dental practitioners are aware of this practice and resulting complications when treating families from sub‐Saharan East Africa. 相似文献
55.
Objective:To compare changes in pharyngeal airway volume and minimal cross-sectional area (MCA) between patients undergoing rapid maxillary expansion (RME) and a matched control group and to identify markers for predicting airway changes using cone-beam computed tomography (CBCT).Materials and Methods:Pre- and posttreatment CBCT scans were selected of children who had RME (14 girls and 12 boys; mean age, 12.4 years) along with scans of a control group (matched for chronological age, skeletal age, gender, mandibular inclination) who underwent orthodontic treatment for minor malocclusions without RME. Changes in airway volume and MCA were evaluated using a standardized, previously validated method and analyzed by a mixed-effects linear regression model.Results:Upper airway volume and MCA increased significantly over time for both the RME and matched control groups (P < .01 and P = .05, respectively). Although the RME group showed a greater increase when compared with the matched controls, this difference was not statistically significant. A reduced skeletal age before treatment was a significant marker for a positive effect on the upper airway volume and MCA changes (P < .01).Conclusions:Tooth-borne RME is not associated with a significant change in upper airway volume or MCA in children when compared with controls. The younger the skeletal age before treatment, the more positive the effect on the upper airway changes. The results may prove valuable, especially in RME of young children. 相似文献
56.
57.
Andrew J Klink Landon Z Marshall Abdalla Aly Brian Seal Marcus J Healey Bruce Feinberg 《The oncologist》2022,27(3):e265
BackgroundThe treatment landscape for advanced hepatocellular carcinoma (aHCC) is rapidly expanding beyond tyrosine kinase inhibitors (TKIs) in the first-line (1L) setting, with multiple TKIs and immune-checkpoint inhibitors (ICIs) now being evaluated in combination. Real-world evidence describing current treatment patterns and reasons for 1L and 2L treatment selection in aHCC is sparse.Patients and MethodsA retrospective cohort study with a cross-sectional survey element was conducted using Cardinal Health’s Oncology Provider Extended Network. U.S. medical oncologists identified adult aHCC patients initiating 1L systemic therapy between January 1, 2017 and July 31, 2019 and abstracted data from patient medical records. Data included provider characteristics, patient demographics and clinical characteristics, treatment regimens, and physician rationale for treatment regimen choice.ResultsA total of 44 medical oncologists provided data on 284 aHCC patients. The median age at 1L initiation was 61.5 years, and the majority were male (78%) and white (66%). Nearly half (47%) initiated 1L treatment in 2019, 34% were ECOG performance status 2+, and 63% were Child-Pugh Class B/C. Among the 284 aHCC patients, TKIs were used by 94% of patients in the 1L setting, comprised predominantly of sorafenib (54%) and lenvatinib (38%). ICIs were most common among the 90 patients (66%) who received 2L treatment.ConclusionIn the community-oncology practice setting, nearly all aHCC patients received sorafenib or lenvatinib in the 1L setting, while the majority of patients received an ICI in the 2L setting. With recent ICI approvals in aHCC, this marks the beginning of an increased use of ICIs in the 1L setting. 相似文献
58.
Despoina Eleftheriadou Rachael E. Evans Emily Atkinson Ahmed Abdalla Francesca K. H. Gavins Ashleigh S. Boyd Gareth R. Williams Jonathan C. Knowles Victoria H. Roberton James B. Phillips 《RSC advances》2022,12(7):4005
Treatment options for neurodegenerative conditions such as Parkinson''s disease have included the delivery of cells which release dopamine or neurotrophic factors to the brain. Here, we report the development of a novel approach for protecting cells after implantation into the central nervous system (CNS), by developing dual-layer alginate beads that encapsulate therapeutic cells and release an immunomodulatory compound in a sustained manner. An optimal alginate formulation was selected with a view to providing a sustained physical barrier between engrafted cells and host tissue, enabling exchange of small molecules while blocking components of the host immune response. In addition, a potent immunosuppressant, FK506, was incorporated into the outer layer of alginate beads using electrosprayed poly-ε-caprolactone core–shell nanoparticles with prolonged release profiles. The stiffness, porosity, stability and ability of the alginate beads to support and protect encapsulated SH-SY5Y cells was demonstrated, and the release profile of FK506 and its effect on T-cell proliferation in vitro was characterized. Collectively, our results indicate this multi-layer encapsulation technology has the potential to be suitable for use in CNS cell delivery, to protect implanted cells from host immune responses whilst providing permeability to nutrients and released therapeutic molecules.Novel composite cell encapsulation system: dual-layer, micro-scale beads maintain cell survival while releasing immunomodulatory FK506 in a sustained manner. This biotechnology platform could be applicable for treatment of CNS and other disorders. 相似文献
59.
Nathan Beaupel Solafah Abdalla Franck Carbonnel Christophe Penna Stéphane Benoist 《Scandinavian journal of gastroenterology》2017,52(1):5-10
Objective: Exclusive polymeric diet enriched with transforming growth factor-beta 2 (ANS-TGF-β2) has been used for remission induction and maintenance in pediatric Crohn’s disease (CD). Its use in the preoperative setting has never been evaluated. The aim of this study was to evaluate preoperative ANS-TGF-β2 to decrease postoperative complications after surgery for complicated ileocolonic CD.Methods: From 2011 to 2015, data of all consecutive patients who underwent elective surgery for ileocolonic CD were collected prospectively. Preoperative, exclusive ANS-TGF-β2 was administered in high-risk patients with complicated CD. Complicated CD was defined by the presence of obstructive symptoms, and/or steroid treatment, and/or preoperative weight loss >10% and/or perforating CD. Outcomes of high-risk patients receiving preoperative ANS-TGF-β2 were compared to those of low-risk patients with no complicated CD who underwent upfront surgery.Results: Fifty-six patients underwent surgery for ileocolonic CD. Among them, 35 high-risk patients received preoperative ANS-TGF-β2 and 21 low-risk patients underwent upfront surgery. Preoperative full-dose ANS-TGF-β2 was feasible in 34/35 high-risk patients. Discontinuation of steroids during preoperative ANS-TGF-β2 could be achieved in 10/16 patients (62.5%). Postoperative complications rates were 8/35 (23.8%) and 5/21 (22.9%) in high-risk and low-risk patients, respectively (p?=?1). Temporary ileocolostomy rates in high-risk patients and in low-risk patients were 4/35 (11%) and 0/21, respectively (p?=?0.286)Conclusion: Preoperative ANS-TGF-β2 is feasible in most high-risk patients with complicated ileocolonic CD and could limit the deleterious effects of risk factors of postoperative morbidity. These results need to be confirmed in a large randomized controlled trial. 相似文献
60.
Salah Eldin M. E. Hassan Mohamed Alamin Ahmed Sabir Taha Hussein Abdallah Elamin Elsheikh Moh. Mah. Fadel Alla Eljack Mazin SalahEldien Hassan Haroun Khabab Abbasher Hussien Mohamed Ahmed Mohammed Eltahier Abdalla Omer Ghassan Elfatih Mustafa 《Clinical Case Reports》2022,10(1)
A 3‐year‐old child presented with recurrent chest pain for 3 months, echocardiography showed a thorn inside the left ventricle, the patient was diagnosed with foreign body complicated with infective endocarditis and received proper treatment, and operation was performed after inflammatory reaction subsided. 相似文献