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91.
Wen Lihong Chen Xin Cheng Qi Nie Liuyan Xu Jieying Yan Tingting Zhang Xin Yang Huanhuan Sun Wenjia Liu Lei Xue Jing Du Yan 《Clinical rheumatology》2022,41(11):3419-3427
Clinical Rheumatology - The purpose of this study was to determine the incidence of myositis-specific autoantibodies (MSAs) in a cohort of Chinese patients with idiopathic inflammatory myopathies... 相似文献
92.
Background:Pain caused by oral mucositis (OM) is the main problem in the process of concurrent chemoradiotherapy for the nasopharyngeal carcinoma (NPC). This protocol aims to explore the standardized nursing and therapeutic effect of OxyContin on OM pain in the patients with NPC undergoing the concurrent chemoradiotherapy.Methods:The experiment is a randomized clinical research, which was granted through the Research Ethics Committee of Shandong Provincial Third Hospital (No.20200802097). In this research, 90 NPC patients with OM induced by chemotherapy are enrolled, and the score of visual analogue >5 and the grade of OM >1 are evaluated. Patients with known allergy to OxyContin, the opioid abuse history, or major organ dysfunction, for instance, hepatic insufficiency, renal failure, and respiratory and heart failure, as well as a series of severe mental illness are excluded from our research. Patients in study groups receive standardized nursing and oral OxyContin. Patients in control groups only receive oral OxyContin. The analgesic effect could be assessed with the comparison of the visual analogue scale after and before the treatment. Safety evaluations contain the assessment of the vital signs, laboratory tests, as well as adverse events. The Karnofsky performance status standards of the International Cancer Control Union is utilized to evaluate the quality of life.Results:The comparison of outcomes after taking OxyContin in both groups will be shown in Table Table1Table1 .Table 1The comparison of outcomes after taking OxyContin in both groups.
Open in a separate windowConclusion:The combination of OxyContin and standardized nursing care appears to improve the analgesic efficacy and life quality in NPC patients.Trial registration: We registered this protocol in Research Registry (researchregistry6098). 相似文献
Variables | Study group (n = 45) | Control group (n = 45) | P value |
Pain relief | |||
Quality of life measures before and after treatment | |||
Psychological field | |||
OxyContin consumption | |||
Complications |
93.
Deciphering principles of morphogenesis from temporal and spatial patterns on the integument 下载免费PDF全文
Ang Li Yung‐Chih Lai Seth Figueroa Tian Yang Randall B. Widelitz Krzysztof Kobielak Qing Nie Cheng Ming Chuong 《Developmental dynamics》2015,244(8):905-920
Background : How tissue patterns form in development and regeneration is a fundamental issue remaining to be fully understood. The integument often forms repetitive units in space (periodic patterning) and time (cyclic renewal), such as feathers and hairs. Integument patterns are visible and experimentally manipulatable, helping us reveal pattern formative processes. Variability is seen in regional phenotypic specificities and temporal cycling at different physiological stages. Results: Here we show some cellular/molecular bases revealed by analyzing integument patterns. (1) Localized cellular activity (proliferation, rearrangement, apoptosis, differentiation) transforms prototypic organ primordia into specific shapes. Combinatorial positioning of different localized activity zones generates diverse and complex organ forms. (2) Competitive equilibrium between activators and inhibitors regulates stem cells through cyclic quiescence and activation. Conclusions: Dynamic interactions between stem cells and their adjacent niche regulate regenerative behavior, modulated by multi‐layers of macro‐environmental factors (dermis, body hormone status, and external environment). Genomics studies may reveal how positional information of localized cellular activity is stored. In vivo skin imaging and lineage tracing unveils new insights into stem cell plasticity. Principles of self‐assembly obtained from the integumentary organ model can be applied to help restore damaged patterns during regenerative wound healing and for tissue engineering to rebuild tissues. Developmental Dynamics 244:905–920, 2015. © 2015 Wiley Periodicals, Inc. 相似文献
94.
Yanghao Liu Wen Nie Yubing Mu Haihan Zhang Hongkun Wang Hu Jin Zhiqiang Liu 《RSC advances》2018,8(21):11498
In this paper, a highly efficient and environmentally-friendly dust depressor was developed based on the sodium lignosulfonate–acrylic acid graft copolymer. Using the grafting ratio as an index, a three-factor and four-level orthogonal experiment was conducted to optimize the fabrication conditions of the graft copolymer. At a reaction temperature of 60 °C, feed ratio mSLS–AA of 1 : 3, and FeSO4·7H2O content of 2.5%, the prototype produced the highest grafting ratio. The microstructure of the graft copolymer was measured using Fourier transform infrared spectrometry (FTIR) and nuclear magnetic resonance (1H-NMR). Furthermore, the influence of glycerol and the JFC penetrant on the contact angle between the compound solution and coal powder was investigated. Finally, four formulas of dust depressor were selected based on the experimental results. The dust-control performance of the four dust depressors was then tested on a large-scale spray dust suppression simulation platform. The results show that after applying formula 1 at various distances from the spray field, the average dust reduction rates of the total dust (respirable dust) at each point increased. Compared to the water-spraying dust suppression technique, the dust concentration is significantly reduced after the graft copolymer dust depressor is applied.In this paper, a highly efficient and environmentally-friendly dust depressor was developed based on the sodium lignosulfonate–acrylic acid graft copolymer. 相似文献
95.
目的探讨电子支气管镜检查术在儿童反复咳喘性疾病中的应用价值。方法对该院2015年3月-2017年11月收治的297例反复咳嗽、喘息的患儿行支气管镜检查及治疗的临床资料进行综合分析。结果 297例反复咳喘的患儿支气管镜检查镜下表现最常见的是支气管内膜炎,共193例,占65.0%,是反复咳喘患儿最常见的表现;气管、支气管软化的患儿23例,占7.7%;喉软化者18例,占6.1%;气管、支气管狭窄者13例,占4.4%;异物者7例,占2.4%;结构异常者17例,占5.8%;肺含铁血黄素沉着症2例,占0.7%;肿瘤2例,占0.7%;左主支气管未发育1例,占0.3%;支气管憩室1例,占0.3%;支气管镜下未见明显异常者20例,占6.7%。结论对于儿童反复咳喘性疾病,支气管镜检查能够明确病因并且指导治疗,在临床上应用价值较高。 相似文献
96.
目的 分析河南省MSM人群HIV感染流行趋势,为河南省艾滋病防治政策与策略制定提供科学依据。方法 分析2008-2013年艾滋病病例报告系统中同性性传播HIV/AIDS病例的变化趋势,利用MSM人群艾滋病综合防治专项调查数据分析该人群HIV感染率及危险行为变化。结果 2008-2013年河南省同性性传播病例构成从1.3%上升到17.1%,呈现快速增长趋势;专项调查数据显示,MSM人群HIV感染率呈现快速上升趋势,从2008年的4.69%增至2013年的8.33%(趋势χ2=39.24,P<0.001).单因素分析结果显示,年龄(χ2=21.03,P<0.001)、文化程度(χ2=31.66,P<0.001)、职业(χ2=14.59,P=0.01)、最近1次肛交行为安全套使用情况(χ2=134.97,P<0.001)、最近6个月同性性行为安全套使用情况(χ2=97.15,P<0.001)、最近1年性病症状(χ2=67.21,P<0.001)以及梅毒感染(χ2=163.60,P<0.001)均为感染HIV的影响因素。多因素分析结果显示,年龄、性病症状史、感染梅毒与艾滋病防治知识不知晓为感染HIV的危险因素。结论 河南省MSM人群中HIV感染呈不断上升趋势,男男同性性传播已经成为主要感染途径,该人群不安全性行为普遍存在,亟需采取有效措施控制HIV在该人群中的传播。 相似文献
97.
目的 了解武汉市进行抗病毒治疗(ART)的HIV感染者及艾滋病患者(HIV/AIDS) 社会支持现状,并探讨其影响因素。方法 应用社会支持评定量表(SSRS)评价武汉市330例进行ART的HIV/AIDS社会支持现状;采用t检验、方差分析和多元线性回归模型分析社会支持的影响因素。结果 HIV/AIDS主观支持、客观支持、对社会支持利用度以及社会支持总体得分均低于中国常模(P<0.05)。多元线性回归分析显示,未婚/离异/丧偶者客观支持(β''=-0.260)、主观支持(β''=-0.196)、社会支持总体(β''=-0.141)得分低于已婚者(P<0.05);文化程度较高者客观支持(β''=0.250)、对支持利用度(β''=0.232)得分高于文化程度低者(P<0.05);近两周没有AIDS相关症状者主观支持得分高于有相关症状者(β''=0.232,P<0.05)。结论 武汉市进行ART的HIV/AIDS社会支持状况低于正常人群,应关注未婚/离异/丧偶者、文化程度较低者和伴有HIV相关症状者,提高其社会支持水平。 相似文献
98.
聂上伟 《成都中医药大学学报(教育科学版)》2015,(2):63-64,70
运用文献资料法、数理统计法和对比实验法等研究方法,对多媒体技术在高校羽毛球课堂教学中的应用研究,探讨多媒体技术对促进教学效果和提高学习效率中的作用与意义。结果表明:多媒体技术的运用符合高校羽毛球教学目标,并能够充分调动学生的积极性,更快建立完整、正确的技术动作表象,更好掌握技术要领,提高羽毛球教学效果,促进高校体育教师教学观念的转变和教学手段的现代化,适应现代教育的发展。 相似文献
99.
Bei Hu Xin Ouyang Liming Lei Cheng Sun Ruibin Chi Jian Guo Wenlong Guo Yanlin Zhang Yong Li Daoyong Huang Huafeng Sun Zhiqiang Nie Jieyang Yu Yuan Zhou Hao Wang Jinhe Zhang Chunbo Chen 《Intensive care medicine》2018,44(12):2174-2182
Purpose
To determine whether erythromycin is non-inferior to metoclopramide in facilitating post-pyloric placement of self-propelled spiral nasoenteric tubes (NETs) in critically ill patients.Methods
A prospective, multicenter, open-label, parallel, and non-inferiority randomized controlled trial was conducted comparing erythromycin with metoclopramide in facilitating post-pyloric placement of spiral NETs in critically ill patients admitted to intensive care units (ICUs) of eight tertiary hospitals in China. The primary outcome was procedure success defined as post-pyloric placement (spiral NETs reached the first portion of the duodenum or beyond confirmed by abdominal radiography 24 h after tube insertion).Results
A total of 5688 patients were admitted to the ICUs. Of these, in 355 patients there was a plan to insert a nasoenteric feeding tube, of whom 332 were randomized, with 167 patients assigned to the erythromycin group and 165 patients assigned to the metoclopramide group. The success rate of post-pyloric placement was 57.5% (96/167) in the erythromycin group, as compared with 50.3% (83/165) in the metoclopramide group (a difference of 7.2%, 95% CI ??3.5% to 17.9%), in the intention-to-treat analysis, not including the prespecified margin of ??10% for non-inferiority. The success rates of post-D1 (reaching the second portion of the duodenum or beyond), post-D2 (reaching the third portion of the duodenum or beyond), post-D3 (reaching the fourth portion of the duodenum or beyond), and proximal jejunum placement and the incidence of any adverse events were not significantly different between the groups.Conclusions
Erythromycin is non-inferior to metoclopramide in facilitating post-pyloric placement of spiral NETs in critically ill patients. The success rates of post-D1, post-D2, post-D3, and proximal jejunum placement were not significantly different.100.
目的:评价Ahmed 青光眼阀植入术治疗玻璃体手术后继发性青光眼的临床疗效。
方法:回顾分析在我院眼科应用Ahmed青光眼阀植入术治疗玻璃体手术后继发性青光眼患者23例23眼。
结果:患者术后平均随访29±3.7mo,术前平均眼压48.79±7.12mmHg,手术后24mo时平均眼压23.28±10.53mmHg,与术前眼压相比明显降低,具有显著性统计学差异(P<0.05); 术后1mo时,手术成功率82.6%,随访12、24mo时手术成功率分别为65.2%、52.2%。
结论:采用Ahmed青光眼阀植入术治疗玻璃体手术后的继发性青光眼是比较有效和相对安全的治疗方法。 相似文献