全文获取类型
收费全文 | 6346篇 |
免费 | 343篇 |
国内免费 | 36篇 |
专业分类
耳鼻咽喉 | 161篇 |
儿科学 | 147篇 |
妇产科学 | 165篇 |
基础医学 | 860篇 |
口腔科学 | 139篇 |
临床医学 | 470篇 |
内科学 | 1484篇 |
皮肤病学 | 380篇 |
神经病学 | 455篇 |
特种医学 | 347篇 |
外科学 | 891篇 |
综合类 | 56篇 |
预防医学 | 363篇 |
眼科学 | 109篇 |
药学 | 354篇 |
中国医学 | 6篇 |
肿瘤学 | 338篇 |
出版年
2021年 | 78篇 |
2020年 | 47篇 |
2019年 | 70篇 |
2018年 | 96篇 |
2017年 | 64篇 |
2016年 | 103篇 |
2015年 | 124篇 |
2014年 | 149篇 |
2013年 | 180篇 |
2012年 | 270篇 |
2011年 | 263篇 |
2010年 | 163篇 |
2009年 | 174篇 |
2008年 | 262篇 |
2007年 | 300篇 |
2006年 | 258篇 |
2005年 | 268篇 |
2004年 | 273篇 |
2003年 | 268篇 |
2002年 | 223篇 |
2001年 | 187篇 |
2000年 | 252篇 |
1999年 | 232篇 |
1998年 | 96篇 |
1997年 | 93篇 |
1996年 | 74篇 |
1995年 | 55篇 |
1994年 | 46篇 |
1993年 | 44篇 |
1992年 | 95篇 |
1991年 | 109篇 |
1990年 | 109篇 |
1989年 | 134篇 |
1988年 | 102篇 |
1987年 | 78篇 |
1986年 | 81篇 |
1985年 | 72篇 |
1984年 | 54篇 |
1983年 | 51篇 |
1979年 | 53篇 |
1978年 | 41篇 |
1977年 | 43篇 |
1976年 | 34篇 |
1975年 | 47篇 |
1974年 | 47篇 |
1973年 | 56篇 |
1972年 | 43篇 |
1971年 | 46篇 |
1970年 | 37篇 |
1969年 | 37篇 |
排序方式: 共有6725条查询结果,搜索用时 15 毫秒
111.
Reduction of monocyte-platelet interaction and monocyte activation in patients receiving antiplatelet therapy after coronary stent implantation 总被引:2,自引:0,他引:2
May A. E.; Neumann F.-J.; Gawaz M.; Ott I.; Walter H.; Schomig A. 《European heart journal》1997,18(12):1913-1920
BACKGROUND: Monocyte activation induces different procoagulant and proadhesiveinflammatory responses and thus may play a role in thromboticcomplications after coronary interventions. Monocyte-plateletinteraction may trigger these effects inducing monocyte activation. AIMS: To characterize the effect of antiplatelet vs anticoagulationtherapy on monocyte-platelet interaction and monocyte functionafter intracoronary stenting. METHODS AND RESULTS: Immediately before, and during the first 12 days after successfulcoronary stenting, monocyteplatelet conjugates and monocytefunction were assessed by flow cytometric detection of GPIIb/IIIa(CD41) on monocytes and by monocyte surface exposure of Mac-1(CD11b/ CD18) and L-selectin (CD62L). Twenty patients receivingcombined antiplatelet therapy (ticlopidine, aspirin) were comparedto 20 patients with standard anticoagulation (phenprocoumon,overlapping heparin, aspirin). Before stenting, monocyte-plateletconjugates and Mac-1 surface expression in both groups weresignificantly increased, while L-selectin was significantlydiminished. Anticoagulation did not change these variables significantlyduring the subsequent 12 days. In contrast, antiplatelet therapyreduced platelet-monocyte conjugates by 46±9·3%(mean±SEM, P=0·0019) within 4 days, which wasassociated with a decrease in Mac-1 expression (28±6·7%,P=0·0013) and an increase in L-selectin (56±15·0%,P=0·0061). CONCLUSION: After intracoronary stenting, combined antiplatelet therapy,but not anticoagulation, causes reduction of monocyte-plateletinteraction, which is associated with monocyte deactivation.This may contribute to a decreased risk for thrombotic events. 相似文献
112.
Martin MJ Heymann C Neumann T Schmidt L Soost F Mazurek B Böhm B Marks C Helling K Lenzenhuber E Müller C Kox WJ Spies CD 《Alcoholism, clinical and experimental research》2002,26(6):836-840
BACKGROUND: Alcoholics are at risk of developing major complications in the postoperative period. Adequate prophylactic treatment, as well as preoperative abstinence, can significantly decrease the rate of complications. However, the preoperative diagnosis of alcoholism is difficult to establish. The purpose of this study was to assess whether three preoperative visits, an alcohol-related questionnaire (CAGE), and the laboratory markers carbohydrate-deficient transferrin (CDT) and gamma-glutamyltransferase (GGT) would increase the rate of detection of chronic alcoholics. METHODS: The study included the Departments of ENT, Facial and Maxillofacial Surgery, and General Surgery of a university hospital; 705 male patients were assessed for tumor surgery of the upper digestive tract and were allocated to 5 different groups. All patients were seen three times, and five different strategies were used to detect chronic alcoholics. The gold standard was the diagnosis of alcohol misuse made by an experienced (blinded) investigator according to the DSM-III-R. The main outcome measurements were the detection rates of the different test strategies. RESULTS: By clinical routine alone, only 16% were detected during the first visit and 34% after three visits. If the CAGE questionnaire was added, sensitivity increased to 64%. The further addition of GGT or CDT led to 80 and 85% detections, respectively. A combination of all tests had a sensitivity of 91%. CONCLUSIONS: To detect more alcoholic patients at risk for major complications, patients should be seen more often, and additional diagnostic tools such as the CAGE, CDT, and GGT should be used before surgery. 相似文献
113.
114.
115.
116.
Thomas A. Ravenscroft Matt C. Baker Nicola J. Rutherford Manuela Neumann Ian R. Mackenzie Keith A. Josephs Bradley F. Boeve Ronald Petersen Glenda M. Halliday Jillian Kril John C. van Swieten William W. Seeley Dennis W. Dickson Rosa Rademakers 《Neurobiology of aging》2013
The nuclear protein fused in sarcoma (FUS) is found in cytoplasmic inclusions in a subset of patients with the neurodegenerative disorder frontotemporal lobar degeneration (FTLD-FUS). FUS contains a methylated arginine–glycine–glycine domain that is required for transport into the nucleus. Recent findings have shown that this domain is hypomethylated in patients with FTLD-FUS. To determine whether the cause of hypomethylation is the result of mutations in protein N-arginine methyltransferases (PRMTs), we selected 3 candidate genes (PRMT1, PRMT3, and PRMT8) and performed complete sequencing analysis and real-time polymerase chain reaction mRNA expression analysis in 20 FTLD-FUS cases. No mutations or statistically significant changes in expression were observed in our patient samples, suggesting that defects in PRMTs are not the cause of FTLD-FUS. 相似文献
117.
Christopher Beale Stefanie Hamacher Alexey Yakushenko Oumaima Bensaid Sabine Willbold Guillermo Beltramo Sren Mller Heinrich Hartmann Elmar Neumann Gregor Mussler Alexander Shkurmanov Dirk Mayer Bernhard Wolfrum Andreas Offenhusser 《RSC advances》2020,10(53):32102
Correction for ‘Tantalum(v) 1,3-propanediolate β-diketonate solution as a precursor to sol–gel derived, metal oxide thin films’ by Christopher Beale et al., RSC Adv., 2020, 10, 13737–13748, DOI: 10.1039/D0RA02558E.The authors regret that the plasma treatment and printing parameters were reported incorrectly in the subsection “Deposition on a-SiO2 for UV/Vis spectrophotometry” in the Experimental section of the original article.Before printing, the substrate for both samples was subjected to an argon plasma treatment for 5 minutes (150 W, 0.6 mbar). The plasma power is now corrected to be the same as stated in the “Deposition on a-SiO2 for Raman/XRD” subsection, where originally it was incorrectly stated that “the power was set slightly higher” for the Raman/XRD samples. For both the acetylacetone and benzoylacetone inks, the inks were printed on their respective substrates with a 75 μm drop pitch having dimensions of 400 × 220 drops to create a uniform layer.The correct section is as follows: 相似文献
118.
119.
120.
A N DeMaria L A Vismara R R Miller A Neumann D T Mason 《The American journal of medicine》1975,59(5):713-720
Although echocardiography has provided a useful noninvasive means for detecting cardiac myxomas, the ultrasound manifestations of these tumors may be variable. We describe our experiences with unusual echographic features encountered in left and right heart myxomas. Thus the left atrial tumor may be manifested predominantly by multiple, discrete, linear echoes behind the mitral valve, the anterior leaflet of which may exhibit an abrupt mid-systolic posterior movement. In right heat myxomatous tumor arising from the septal tricupsid leaflet and adjacent interventricular septum, the echographic characteristics include a cloud of echoes throughout the cardiac cycle in the right ventricular outflow tract which are present in the right ventricle body only during relaxation and are anterior to the tricuspid valve in early diastole. Therefore, discrete linear echoes may be the principal echographic presentation of left atrial myxoma, and special attention should be focused on all areas of the tricuspid valve and right ventricle by ultrasound in patients in whom diagnosis of myxoma is suspected. 相似文献