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A portable target controlled infusion system for propofol has been developed based on a Psion hand-held microcomputer and the Ohmeda 9000 syringe pump. The system uses a pharmacokinetic model which describes the distribution and elimination of propofol to achieve and maintain any selected target blood concentration. Target blood concentrations of 1 g/ml, 3 g/ml and 5 g/ml were selected in laboratory trials and the cumulative volumes delivered by the Psion system each minute were compared with the theoretical output calculated by the pharmacokinetic model. The results obtained showed that the computer system delivered volumes which were always within 2% of the theoretical values. This system offers a convenient and simple method of maintaining anaesthesia using propofol. 相似文献
84.
NC Molony BSc FRCS D Santana-Hernandez DLO LMS PJ Wardrop FRCS M Armstrong FRCS SJ Moralee FRCS 《International journal of clinical practice》1998,52(6):372-373
SUMMARY Anecdotal evidence from several ENT departments suggests that pain following tonsillectomy is worst on the second and/or third days after surgery. This study tests this hypothesis. A pilot study with 19 subjects suggested this theory might well be true. A fuller study was then carried out on 91 subjects with standardised surgical and anaesthetic techniques, and standardised analgesia for five days postoperatively. Pain on the second and third postoperative days was compared with that eight hours after the operation and on the first, fourth and fifth postoperative days. No statistically significant difference was found. There is increasing pressure for early discharge from hospital after surgery. If pain following tonsillectomy is not going to become worse at home, this will tend to make early discharge more acceptable to patients. 相似文献
85.
Martha J Foxall PhD RN Lani Zimmerman PhD RN Roberta Standley MSN RN Barbara Bene Captain USAF NC MSN RN 《Journal of advanced nursing》1990,15(5):577-584
This study compared the frequency and sources of nursing job stress perceived by 35 intensive care (ICU), 30 hospice and 73 medical-surgical nurses. Analysis of variance revealed no significant differences among the three groups of nurses on the overall frequency of job stress. Post-hoc Tukey tests demonstrated a significant difference in three stress subscales among the three groups. ICU and hospice nurses perceived significantly more stress than medical-surgical nurses related to death and dying; ICU and medical-surgical nurses perceived significantly more stress than hospice nurses related to floating; and medical-surgical nurses perceived significantly more stress than ICU and hospice nurses related to work-overload/staffing. Spearman-Rank Correlation revealed no significant correlations among the three groups in their rank-ordering of the eight stress subscales. Death and dying situations were the most stressful to ICU and hospice nurses, while work-overload/staffing situations were the most stressful to medical-surgical nurses. Results of the study, although not generalizable, have implications for nurse managers. 相似文献
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SUMMARY Drugs affecting the leukotriene pathway are emerging as a new class of asthma treatment — the first for more than 20 years. Development of these leukotriene antagonists should lead to greater understanding of the underlying processes in asthma and may result in a safe, oral, anti-asthmatic drug to benefit particular groups of asthmatic patients. 相似文献
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A224 Lenalidomide,Bortezomib, and Dexamethasone Has Notable Activity in High-Risk First-Line Myeloma
88.
Components of the protein synthesis machinery are subjected to
alterations in cancer cells. eEF1D gene, which lies within the frequently amplified
8q24 locus, is one of the subunits of the human eukaryotic elongation factor
complex. This study aimed to evaluate the prognostic and predictive significance
of eEF1D in breast cancer using in silico analysis tools. For this purpose, we
analyzed genomic alterations of the eEF1D gene using TCGA datasets via
cBioPortal. Histopathological analysis was performed on patient tissue images
obtained from cBioPortal and the Human Protein Atlas. Survival analysis was
carried out using the KM Plotter and the prediction of response to therapy was
assessed via the ROC Plotter. We found that eEF1D was highly amplified and
overexpressed in breast invasive carcinoma. Increased expression of eEF1D was
correlated with increased structural disorganization and morphological alterations
at the cellular level, as well as a shorter period of overall survival. Furthermore,
prediction of response to therapy showed that patients with eEF1D overexpression
responded significantly better to endocrine therapy. In conclusion, our results
suggest a cancer-promoting role for eEF1D, associated with poor prognosis and
points towards its predictive value in providing better tailored treatment options
for a patient. 相似文献
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Jason A Thomas Randi E Foraker Noa Zamstein Jon D Morrow Philip R O Payne Adam B Wilcox the NC Consortium 《J Am Med Inform Assoc》2022,29(8):1350
ObjectiveThis study sought to evaluate whether synthetic data derived from a national coronavirus disease 2019 (COVID-19) dataset could be used for geospatial and temporal epidemic analyses.Materials and MethodsUsing an original dataset (n = 1 854 968 severe acute respiratory syndrome coronavirus 2 tests) and its synthetic derivative, we compared key indicators of COVID-19 community spread through analysis of aggregate and zip code-level epidemic curves, patient characteristics and outcomes, distribution of tests by zip code, and indicator counts stratified by month and zip code. Similarity between the data was statistically and qualitatively evaluated.ResultsIn general, synthetic data closely matched original data for epidemic curves, patient characteristics, and outcomes. Synthetic data suppressed labels of zip codes with few total tests (mean = 2.9 ± 2.4; max = 16 tests; 66% reduction of unique zip codes). Epidemic curves and monthly indicator counts were similar between synthetic and original data in a random sample of the most tested (top 1%; n = 171) and for all unsuppressed zip codes (n = 5819), respectively. In small sample sizes, synthetic data utility was notably decreased.DiscussionAnalyses on the population-level and of densely tested zip codes (which contained most of the data) were similar between original and synthetically derived datasets. Analyses of sparsely tested populations were less similar and had more data suppression.ConclusionIn general, synthetic data were successfully used to analyze geospatial and temporal trends. Analyses using small sample sizes or populations were limited, in part due to purposeful data label suppression—an attribute disclosure countermeasure. Users should consider data fitness for use in these cases. 相似文献