全文获取类型
收费全文 | 20159篇 |
免费 | 1183篇 |
国内免费 | 149篇 |
专业分类
耳鼻咽喉 | 166篇 |
儿科学 | 450篇 |
妇产科学 | 383篇 |
基础医学 | 2246篇 |
口腔科学 | 768篇 |
临床医学 | 1907篇 |
内科学 | 4333篇 |
皮肤病学 | 429篇 |
神经病学 | 1277篇 |
特种医学 | 489篇 |
外国民族医学 | 7篇 |
外科学 | 2686篇 |
综合类 | 526篇 |
一般理论 | 15篇 |
预防医学 | 1752篇 |
眼科学 | 785篇 |
药学 | 1900篇 |
中国医学 | 229篇 |
肿瘤学 | 1143篇 |
出版年
2024年 | 31篇 |
2023年 | 256篇 |
2022年 | 736篇 |
2021年 | 1132篇 |
2020年 | 749篇 |
2019年 | 910篇 |
2018年 | 1082篇 |
2017年 | 751篇 |
2016年 | 827篇 |
2015年 | 817篇 |
2014年 | 1110篇 |
2013年 | 1285篇 |
2012年 | 1742篇 |
2011年 | 1805篇 |
2010年 | 1059篇 |
2009年 | 802篇 |
2008年 | 1168篇 |
2007年 | 1068篇 |
2006年 | 902篇 |
2005年 | 786篇 |
2004年 | 612篇 |
2003年 | 499篇 |
2002年 | 434篇 |
2001年 | 76篇 |
2000年 | 76篇 |
1999年 | 75篇 |
1998年 | 56篇 |
1997年 | 52篇 |
1996年 | 46篇 |
1995年 | 42篇 |
1994年 | 21篇 |
1993年 | 37篇 |
1992年 | 42篇 |
1991年 | 28篇 |
1990年 | 29篇 |
1989年 | 33篇 |
1988年 | 27篇 |
1987年 | 26篇 |
1986年 | 29篇 |
1985年 | 26篇 |
1984年 | 23篇 |
1983年 | 18篇 |
1982年 | 17篇 |
1981年 | 12篇 |
1980年 | 13篇 |
1979年 | 14篇 |
1976年 | 12篇 |
1974年 | 11篇 |
1972年 | 13篇 |
1969年 | 11篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
131.
Fatemeh Karimi Esmaeil Biazar Saeed Heidari-Keshel Bahareh Pourjabbar Mohammad Reza Khataminezhad Shervin Shirinbakhsh S. Yasaman Zolfaghari-Moghaddam 《RSC advances》2022,12(21):13472
Platelet-rich fibrin (PRF) as a rich source of effective growth factors has been used as a scaffold in tissue regeneration. It is known that PRF exhibits rapid degradability against enzymes, which should be decreased using crosslinking agents to reduce the release rate of growth factors and increase the effectiveness of tissue regeneration. In this study, a carbodiimide crosslinker with different concentrations (0.01%, 0.05%, 1%, and 2%) was used to modify and improve the properties of PRF gel. The crosslinked gels were evaluated with analyses such as SEM, swelling, degradability, mechanical strength, release test, cytotoxicity, and cell adhesion. The results showed that with increasing crosslinker concentration, the morphology of the fiber structure changes drastically, the swelling rate decreases from 300% (control) to 160% for the crosslinked gel, the degradation time for the control sample increases from 8 days to more than two weeks for the crosslinked gel, and the Young''s modulus increases from 0.15 MPa (control) to 0.61 MPa for the crosslinked samples. Growth factors also showed lower release with increasing crosslinking ratio. Cytotoxicity assays demonstrated that by increasing the crosslinker concentration to 1% w/v, no cytotoxicity was observed. Cellular studies with DAPI staining showed that the cells penetrated well into the gels and were well distributed, especially in gels with lower crosslinker concentrations. In addition, the modified PRF gel can be used as a scaffold for tissue regeneration.1-Ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride (EDC) as a crosslinker can improve the physical and mechanical properties of PRF gel by forming covalent bonds. 相似文献
132.
Iqra Jabbar Yasir Zaman Khaled Althubeiti Sattam Al Otaibi M. Zahid Ishaque Nasir Rahman Mohammad Sohail Alamzeb Khan Asad Ullah Tommaso Del Rosso Quaid Zaman Rajwali Khan Aurangzeb Khan 《RSC advances》2022,12(21):13456
The hydrothermal method was used to create dilute magnetic semiconductor nanoparticles of Zn1−xCoxO (x = 0, 0.01, 0.05, 0.09). The effect of cobalt doping on the microstructure, morphological and optical properties of Zn1−xCoxO was also studied and the Co doping to host ZnO was confirmed from XRD and EDX analysis. The structural analysis showed that doping of cobalt into ZnO decreased the crystallinity, but the preferred orientation didn''t change. SEM analysis revealed that the cobalt dopant did not have a strong influence on the shape of the synthesized nanoparticles. No defect-related absorption peaks were observed in the UV-Vis spectra. The crystallinity of the doped samples was improved by high growth temperature and long growth time. Ferromagnetic behavior above room temperature was detected in co-doped ZnO nanoparticles. The ferromagnetic behavior increased with increasing Co (up to x = 0.05) doping. The ferromagnetic behavior declined when the Co content was further increased. Related research shows that doped ZnO nanoparticles have better dielectric, electrical conductivity, and magnetic properties than pure ZnO. This high ferromagnetism is usually a response reported for dilute magnetic semiconductors. These semiconductor nanoparticles were further used to designed spintronic based applications.The enlarged central part M–H loop shows for the Co = 0.09 doped ZnO sample, the ferromagnetic (FM) behavior increased, i.e., a Mr of 0.2412 emu g−1 with a Hc of 85 Oe. 相似文献
133.
Hisham S. M. Abd-Rabboh Khaled F. Fawy Mohamed S. Hamdy SeragEldin I. Elbehairi Ali A. Shati Mohammad Y. Alfaifi Hala A. Ibrahium Saad Alamri Nasser S. Awwad 《Materials》2022,15(11)
Bio-based silica, lignocellulose, and activated carbon were simply produced via the recycling of Hassawi rice biomass waste of Al-Ahsa governorate in the eastern Saudi Arabia region using a fast chemical treatment procedure. Rice husk and rice straw wastes were collected, ground, and chemically treated with sodium hydroxide to extract silica/silicate from the dried plant tissues. The liquid extract is then treated with acid solutions in order to precipitate silica/silicate at neutral medium. Lowering the pH of the supernatant to 2 resulted in the precipitation of lignocellulose. Thermal treatment of the biomass residue under N2 gas stream resulted in activated carbon production. Separated products were dried/treated and characterized using several physical examination techniques, such as FT-IR, SEM/EDX, XRD, and Raman spectroscopy in order to study their structure and morphology. Silica and lignocelluloses products were then preliminarily used in the treatment of wastewaters and water-desalination processes. 相似文献
134.
Gauri Mishra Anouk Dev Eldho Paul William Kemp Ammar Majeed John Lubel Sally Bell Paul Gow Amanda Nicoll Siddharth Sood Alex Thompson Marno Ryan Stuart K.Roberts 《肝癌研究(英文版)》2021,(7):66-79
Aim: Transarterial chemoembolisation (TACE) is recommended therapy for intermediate-stage hepatocellular carcinoma (HCC). However, the wide variations in outcom... 相似文献
135.
Mahdi Asghari Ozma Amin Abbasi Sousan Akrami Masoud Lahouty Nayyer Shahbazi Khudaverdi Ganbarov Pasquale Pagliano Sahar Sabahi ükran Kse Mehdi Yousefi Sounkalo Dao Mohammad Asgharzadeh Hedayat Hosseini Hossein Samadi Kafil 《Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive》2022,30(2):180
136.
Simona Sacco Faisal Mohammad Amin Messoud Ashina Lars Bendtsen Christina I. Deligianni Raquel Gil-Gouveia Zaza Katsarava Antoinette MaassenVanDenBrink Paolo Martelletti Dimos-Dimitrios Mitsikostas Raffaele Ornello Uwe Reuter Margarita Sanchez-del-Rio Alexandra J. Sinclair Gisela Terwindt Derya Uluduz Jan Versijpt Christian Lampl 《The journal of headache and pain》2022,23(1)
BackgroundA previous European Headache Federation (EHF) guideline addressed the use of monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway to prevent migraine. Since then, randomized controlled trials (RCTs) and real-world evidence have expanded the evidence and knowledge for those treatments. Therefore, the EHF panel decided to provide an updated guideline on the use of those treatments.MethodsThe guideline was developed following the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) approach. The working group identified relevant questions, performed a systematic review and an analysis of the literature, assessed the quality of the available evidence, and wrote recommendations. Where the GRADE approach was not applicable, expert opinion was provided.ResultsWe found moderate to high quality of evidence to recommend eptinezumab, erenumab, fremanezumab, and galcanezumab in individuals with episodic and chronic migraine. For several important clinical questions, we found not enough evidence to provide evidence-based recommendations and guidance relied on experts’ opinion. Nevertheless, we provided updated suggestions regarding the long-term management of those treatments and their place with respect to the other migraine preventatives.ConclusionMonoclonal antibodies targeting the CGRP pathway are recommended for migraine prevention as they are effective and safe also in the long-term.Supplementary InformationThe online version contains supplementary material available at 10.1186/s10194-022-01431-x. 相似文献
137.
138.
Ariff Azfarahim Ibrahim Mohd Ammar Ihsan Ahmad Zamzuri Rosnah Ismail Ahmad Husni Ariffin Aniza Ismail Muhamad Hazizi Muhamad Hasani Mohd Rizal Abdul Manaf 《Medicine》2022,101(30)
The Teleprimary Care—Oral Health Clinical Information System (TPC-OHCIS) is an updated electronic medical record (EMR) that has been applied in Malaysian primary healthcare. Recognizing the level of patient satisfaction following EMR implementation is crucial for assessing the performance of health care services. Hence, the main objective of this study was to compare the level of patient satisfaction between EMR-based clinics and paper-based clinics.The study was a quasi-experimental design that used a control group and was conducted among patients in 14 public primary healthcare facilities in the Seremban district of Malaysia from May 10, to June 30, 2021. Patient satisfaction was assessed using the validated Short-Form Patient Satisfaction Questionnaire, which consisted of 7 subscales. All data were analyzed using the IBM Statistical Package for Social Sciences version 21.A total of 321 patients consented to participate in this study, and 48.9% of them were from EMR clinics. The mean score for the communication subscale was the highest at 4.08 and 3.96 at EMR-adopted clinics and paper-based record clinics. There were significant differences in general satisfaction and communication subscales, with higher patient satisfaction found in clinics using EMR.With the utilization of EMR, patient satisfaction and communication in delivering healthcare services have improved. 相似文献
139.
Mohammad T. Yousafzai Maryam Alavi Heather Valerio Behzad Hajarizadeh Jason Grebely Gregory J. Dore 《Viruses》2022,14(7)
This study aimed to identify the factors associated with timely (within four weeks) HCV RNA testing and timely (within six months) DAA initiation following HCV notification in the DAA era. We conducted a cohort study of people with an HCV notification in NSW, Australia. Notifications of positive HCV serology were linked to administrative datasets. Weights were applied to account for spontaneous clearance. Logistic regression analyses were performed. Among 5582 people with an HCV notification during 2016–2017, 3867 (69%) were tested for HCV RNA, including 2770 (50%) who received timely testing. Among an estimated 3925 people with chronic HCV infection, 2372 (60%) initiated DAA therapy, including 1370 (35%) who received timely treatment. Factors associated with timely HCV RNA testing included age (≥30 years), female sex, non-Aboriginal ethnicity, country of birth being Australia, and no history of drug dependence. Factors associated with timely treatment were age (≥30 years), male sex, non-Aboriginal ethnicity, country of birth being Australia, no history of drug dependence, and HCV/HIV co-infection. In the DAA era, 50% of people with an HCV notification did not receive timely HCV RNA testing. Most people with an HCV infection received therapy; however, DAA initiation was delayed among many. 相似文献
140.
Yassine Chtourou Maram Morjen Rahma Ammar Rania Mhiri Mohamed Jema Ines ELBini-Dhouib Hamadi Fetoui Najet Srairi-Abid Naziha Marrakchi Jed Jebali 《Nutrients》2022,14(14)
Natural polyphenols are widely reported to have a large range of pharmacological properties, especially antioxidant activities and free radical scavenging capacities. In this study, we investigate the effects of naringin, chlorogenic acid, and quercetin mixtures (NCQ) on renal fibrosis in streptozotocin (STZ)-induced diabetic aged rats and its underlying mechanisms for ten consecutive weeks. The oxidative defense system in the kidneys of treated rats was found to be improved. Several biomarkers were investigated including the blood urea nitrogen, creatinine, and uric acid. Moreover, antioxidant parameters were evaluated and we found that superoxide dismutase, catalase, glutathione peroxidase, Na+-K+-ATPase activities, the nitric oxide production, the protein carbonyl, the advanced oxidation protein products, lipid peroxidation, and reduced glutathione levels were all significantly balanced and close to control values. In addition, NCQ restored renal injuries and fibrosis as assessed by histological method and molecular biology investigation of the matrix metalloproteinase, the transforming growth factor-beta TGF-β, the tumor necrosis factor TNFα, and p53 expression. Our study proposes the NCQ combination as potential plant-derived bioactive compounds to prevent diabetic nephropathy. 相似文献