2003～2007年肇庆市血吸虫病监测

2003～2007年肇庆市血吸虫病监测未查到钉螺和病人,疫情稳定。     

血清肺肿瘤抗原检测对肺癌诊断的价值

目的 探讨一种敏感的肺癌辅助诊断方法。方法 采用乳胶凝集法对１４４例良、恶性肺部疾病患者和２８例健康人血清肺肿瘤抗原（ＬＴＡ）进行检测。结果 肺癌组阳性率７８．３％，对照组阳性率７．６％，差异有非常显著意义（Ｐ〈０．０１）；其中非小细胞肺癌阳性率８８．２％，小细胞肺癌阳性率７．７％，差异亦有非常显著意义（Ｐ〈０．０１）。肿瘤组中包括２例原位癌患者，血清ＬＴＡ检测均呈阳性，说明血清ＬＴＡ检测有助于早     

Lymph Node Metastasis Patterns in Right-Sided Colon Cancers: Is Segmental Resection of These Tumors Oncologically Safe?

Purpose  The type of surgery and the extent of lymphadenectomy depend on the tumor location and should be based on the extent of lymphatic spread and the oncologic outcome. The aim was to analyze patterns of lymph node metastasis in patients with right-sided colon cancer. Methods  Between 1996 and 2007, a total of 419 patients underwent curative resection for right-sided colon cancer. Lymph nodes were grouped immediately after surgery on the basis of the location of the tumor. Results  There were 75, 208, 78, and 58 tumors in the cecum, ascending colon, at the hepatic flexure, and in the transverse colon, respectively. Of the 58 patients with transverse colon tumors, 43, 11, 3, and 1 underwent right hemicolectomies, transverse colectomies, left hemicolectomies, and a subtotal colectomy, respectively. Patients with cecal and ascending colon cancers most frequently had metastases in the ileocolic lymph nodes. Metastasis to the lymph nodes along the right branch of the middle colic artery occurred in 6.1% of patients with cecal cancer. In patients with hepatic flexure cancers, the epicolic lymph nodes along the right and middle colic arteries were most commonly metastatic lymph nodes. In transverse colon cancer, the middle colic node was the most commonly involved lymph node. Approximately 10% of patients had metastases to the right colic nodes. Conclusions  Metastasis to lymph nodes along the right colic artery occurred in approximately 10% of the patients with transverse cancer, indicating the need for great care in deciding the extent of segmental resection for these patients.     

以“标准化医嘱”为重点的同质化临床教学平台在临床实习中的应用

临床实习是当代医学生合法行医之前必须经历的重要实践过程，由于诸多原因目前存在着教学资源供需失衡、教学带教理念滞后，考核、反馈机制不健全等问题。通过对实习教学和改革的探索，坚持以成熟的临床路径信息系统为依托，以临床常见疾病临床路径“标准化医嘱”为临床带教重点，切实地构建 “标准化医嘱”同质化实习平台，不断总结和探索新的带教手段。为进一步提高临床带教效率、改进临床教学效果，保证后期临床实践的“同质化”教学提供有益的借鉴。     

Comparative Genomics of Korean Infectious Bronchitis Viruses (IBVs) and an Animal Model to Evaluate Pathogenicity of IBVs to the Reproductive Organs

The K-I and nephropathogenic K-II genotypes of infectious bronchitis virus (IBV) have been isolated since 1995 and 1990, respectively, in Korea and commercial inactivated oil-emulsion vaccines containing KM91 (K-II type) and Massachusetts 41 strains have been used in the field. To date, genomic analyses of Korean IBV strains and animal models to test the pathogenicity of Korean IBVs to the reproductive organs have been rare. In the present study, comparative genomics of SNU8067 (K-I type) and KM91 IBVs was performed, and an animal model to test the pathogenicity of SNU8067 was established and applied to vaccine efficacy test. The genome sizes of SNU8067 (27,708 nt) and KM91 (27,626 nt) were slightly different and the nucleotide and amino acid identities of the S1 (79%, 77%), 3a (65%, 52%), and 3b (81%, 72%) genes were lower than those of other genes (94%–97%, 92%–98%). A recombination analysis revealed that SNU8067 was a recombinant virus with a KM91-like backbone except S1, 3a, and 3b genes which might be from an unknown virus. An SNU8067 infection inhibited formation of hierarchal ovarian follicles (80%) and oviduct maturation (50%) in the control group, whereas 70% of vaccinated chickens were protected from lesions.     

Herbal dietary regimen combined with massage along the Meridian-and-collateral system to relieve angina pectoris

目的 探讨药膳调理联合经络推按操缓解冠心病心绞痛的临床疗效.方法 将233例冠心病心绞痛患者随机分为四组:对照组57例子常规治疗护理;在此基础上,其余三组辅助给予药膳(药膳组,56例),经络推按操(经络组,60例),药膳调理联合经络推按操(联合组,60例).2周为1个疗程,共观察3个疗程.结果 治疗后四组患者运动试验心电图改变程度及西雅图心绞痛量表(SAQ)评分比较,差异有统计学意义(P＜0.05,P＜0.01),联合组效果最优,对照组效果最差.结论 药膳调理联合经络推按操能提高冠心病心绞痛的临床疗效,更好地改善患者生活质量,且安全、简便.     

胃脘痛患者的精神心理评价报告

目的：了解不同病程的胃脘痛患者的心理状况。方法：采用汉密尔顿焦虑抑郁量表，对228名胃脘痛患者进行焦虑抑郁和不同病程焦虑抑郁的程度进行测定和比较。结果：胃腕痛患者普遍存在焦虑或抑郁或两者并存，且病程越长，焦虑抑郁症状越多，程度越重。     

Mesenchymal Stromal Cells Engineered to Express Erythropoietin Induce Anti-erythropoietin Antibodies and Anemia in Allorecipients

Autologous bone marrow mesenchymal stromal cells (MSCs) have been successfully used for the delivery of erythropoietin (EPO) in murine models of anemia and myocardial infarction. For clinical applications where a transient effect would be adequate, such as myocardial infarction, the use of EPO-engineered universal donor allogeneic MSCs would be a substantial convenience. We thus investigated whether MSCs from C57BL/6 mice would permit robust transient EPO delivery in normal BALB/c allorecipients. Implantation of MSCs overexpressing murine EPO led to increases in hematocrit in syngeneic and allogeneic mice, but the latter eventually developed severe anemia due to acquired neutralizing anti-EPO antibodies. As MSCs constitutively produce the CCL2 chemokine which may behave as an adjuvant to the anti-EPO immune response, experiments were performed using EPO-engineered MSCs derived from CCL2^–/– mice and similar results were obtained. In conclusion, MHC-mismatched MSCs can break the tolerance to autoantigens and lead to the development of pathogenic autoantibodies.     

一次性针头断线控制人工晶状体术后角膜散光

目的 探讨控制白内障摘出及人工晶状体植入术后角膜散光的简易而有效的方法。方法 采用一次性２６号注射针头进行断线处理，观察其角膜散光度及视力的变化，并进行空白对照。结果 处理组角膜散光显著降低，裸眼视力呈明显提高（Ｐ〈０．０１）。结论 一次性针头断线能有效地控制缝线源性角膜散光。     

电视腹腔镜泌尿外科手术36例报告

目的 :探讨腹腔镜治疗泌尿外科疾病的效果。方法 :应用电视腹腔镜治疗泌尿外科疾病 36例 ,其中肾囊肿去顶术 2 2例 ,肾上腺肿瘤切除 10例 ,肾切除 2例 ,隐睾切除 1例 ,肾错构瘤剜除 1例。结果 :一次手术成功 34例 ,1例肾错构瘤 ,1例肾囊肿术中中转开放术。术后平均住院 6± 4d。结论 :腹腔镜手术治疗泌尿外科疾病安全 ,有效 ,损伤小 ,患者术后康复快 ,疤痕少 ,值得推广 ,但须掌握适应证