全文获取类型
收费全文 | 125193篇 |
免费 | 11823篇 |
国内免费 | 7753篇 |
专业分类
耳鼻咽喉 | 1348篇 |
儿科学 | 1574篇 |
妇产科学 | 1166篇 |
基础医学 | 14197篇 |
口腔科学 | 2194篇 |
临床医学 | 13904篇 |
内科学 | 17454篇 |
皮肤病学 | 1926篇 |
神经病学 | 6135篇 |
特种医学 | 5760篇 |
外国民族医学 | 35篇 |
外科学 | 13199篇 |
综合类 | 22198篇 |
现状与发展 | 39篇 |
一般理论 | 7篇 |
预防医学 | 8970篇 |
眼科学 | 3215篇 |
药学 | 13611篇 |
114篇 | |
中国医学 | 7530篇 |
肿瘤学 | 10193篇 |
出版年
2024年 | 282篇 |
2023年 | 1339篇 |
2022年 | 3648篇 |
2021年 | 5184篇 |
2020年 | 3973篇 |
2019年 | 3493篇 |
2018年 | 3766篇 |
2017年 | 3750篇 |
2016年 | 3780篇 |
2015年 | 5631篇 |
2014年 | 7016篇 |
2013年 | 7242篇 |
2012年 | 10400篇 |
2011年 | 11256篇 |
2010年 | 7945篇 |
2009年 | 6908篇 |
2008年 | 8203篇 |
2007年 | 7776篇 |
2006年 | 7324篇 |
2005年 | 6373篇 |
2004年 | 5068篇 |
2003年 | 5037篇 |
2002年 | 4309篇 |
2001年 | 2955篇 |
2000年 | 2344篇 |
1999年 | 1871篇 |
1998年 | 1175篇 |
1997年 | 1065篇 |
1996年 | 873篇 |
1995年 | 789篇 |
1994年 | 739篇 |
1993年 | 484篇 |
1992年 | 473篇 |
1991年 | 467篇 |
1990年 | 364篇 |
1989年 | 326篇 |
1988年 | 231篇 |
1987年 | 217篇 |
1986年 | 178篇 |
1985年 | 132篇 |
1984年 | 80篇 |
1983年 | 50篇 |
1982年 | 46篇 |
1981年 | 32篇 |
1980年 | 38篇 |
1979年 | 21篇 |
1978年 | 11篇 |
1976年 | 16篇 |
1975年 | 13篇 |
1974年 | 12篇 |
排序方式: 共有10000条查询结果,搜索用时 62 毫秒
11.
12.
儿童晕厥临床诊治研究的发展与未来 总被引:1,自引:0,他引:1
儿童晕厥在临床常见,严重影响儿童的身心健康.儿童晕厥诊断关键技术的建立、诊断程序及个体化治疗新策略的提出,显著提高了儿童晕厥的诊治水平.基于研究成果,我国先后制定了多部儿童晕厥诊治指南与专家共识,并在国际期刊颁布了儿童和青少年晕厥指南,充分发挥了中国在国际儿童晕厥诊治领域的引领作用.今后尚需进一步开展儿童晕厥的流行病学研究,优化儿童晕厥预警体系以及干预与预防新策略,进一步推进儿童晕厥事业的发展. 相似文献
13.
皮肤损伤后的异常愈合会导致病理性瘢痕的产生。病理性瘢痕的出现不仅影响美观,严重时还会造成心理和生理功能障碍。病理性瘢痕的机制研究对于瘢痕治疗有极为重要的意义。其中,动物瘢痕模型是目前研究病理性瘢痕的重要模型手段之一。理想的动物瘢痕模型应该在组织学、细胞学等层面尽可能接近于人类的病理性瘢痕。该文分别从传统技术动物瘢痕中的啮齿类动物模型、兔耳模型和猪模型,以及新技术动物瘢痕模型这两个方面,结合近年来在瘢痕领域应用较多的研究,进行了相应系统的阐述。 相似文献
14.
Sophocarpine attenuates toll‐like receptor 4 in steatotic hepatocytes to suppress pro‐inflammatory cytokines synthesis 下载免费PDF全文
16.
目的:探讨改良三点式重睑术的临床应用疗效。方法:2012年6月-2019年6月,共165例单睑患者采用了改良三点式重睑术,沿术前标记线将三点处皮肤切开,剪刀将切口下唇的眼轮匝肌适当去除,同时将切口与切口在皮下层打通,剪除切口与切口之间的眼轮匝肌,6-0可吸收线挂睑板前筋膜或提上睑肌腱膜及切口下唇皮下组织缝合,三点切口各缝1针。再用6-0单丝尼龙线按照常规重睑线缝合方法挂切口下唇皮肤、睑板前筋膜或提上睑肌腱膜及切口上唇皮肤缝合打结,三点切口各缝1针。伴内眦赘皮者同时行内眦赘皮矫正术。结果:152例患者获得随访,随访患者大部分获得了比较满意的重睑,睁眼重睑流畅、自然,闭眼刀口痕迹不明显。2例患者出现内侧重睑线变浅,1例患者出现外侧重睑线变浅,所有患者均未出现重睑消失。5例患者双侧重睑线有轻度不对称。患者总体满意率为94.7%(144/152)。结论:改良三点式重睑术具有创伤小、并发症少、效果逼真、不易脱落、手术痕迹不明显等优点,值得推广应用。 相似文献
17.
18.
19.
JeongYun Choi Haeseung Lee EunJi Kwon HyeonJoon Kong OkSeon Kwon HyukJin Cha 《Molecular oncology》2021,15(2):679
The acquisition of chemoresistance remains a major cause of cancer mortality due to the limited accessibility of targeted or immune therapies. However, given that severe alterations of molecular features during epithelial‐to‐mesenchymal transition (EMT) lead to acquired chemoresistance, emerging studies have focused on identifying targetable drivers associated with acquired chemoresistance. Particularly, AXL, a key receptor tyrosine kinase that confers resistance against targets and chemotherapeutics, is highly expressed in mesenchymal cancer cells. However, the underlying mechanism of AXL induction in mesenchymal cancer cells is poorly understood. Our study revealed that the YAP signature, which was highly enriched in mesenchymal‐type lung cancer, was closely correlated to AXL expression in 181 lung cancer cell lines. Moreover, using isogenic lung cancer cell pairs, we also found that doxorubicin treatment induced YAP nuclear translocation in mesenchymal‐type lung cancer cells to induce AXL expression. Additionally, the concurrent activation of TGFβ signaling coordinated YAP‐dependent AXL expression through SMAD4. These data suggest that crosstalk between YAP and the TGFβ/SMAD axis upon treatment with chemotherapeutics might be a promising target to improve chemosensitivity in mesenchymal‐type lung cancer.
Abbreviations
- AUC
- area under the curve
- AXL
- AXL receptor tyrosine kinase
- BCL2
- B‐cell lymphoma 2
- CTD2
- cancer target discovery and development
- CTGF
- connective tissue growth factor
- DEG
- differentially expressed genes
- DOXO
- doxorubicin
- EMT
- epithelial–mesenchymal transition
- Eto
- etoposide
- FDA
- Food and Drug Administration
- ITGB3
- integrin beta‐3
- MAPK
- mitogen‐activated protein kinase
- MMP2
- matrix metalloproteinase‐2
- MMP9
- matrix metalloproteinase‐9
- mRNA
- messenger RNA
- NF‐κB
- nuclear factor kappa‐light‐chain‐enhancer of activated B cells
- SBE
- SMAD binding element
- SERPINE1
- serpin family E member 1
- siRNA
- small interfering RNA
- ssGSEA
- single‐sample gene set enrichment analysis
- TCGA
- The Cancer Genome Atlas
- TGFβ
- transforming growth factor beta
- YAP
- Yes‐associated protein
- YAP8SA
- mutants of inhibitory phosphorylation site at eight serine to Alanine of YAP
- ZEB1
- zinc finger E‐box binding homeobox 1
- ZEB2
- zinc finger E‐box‐binding homeobox 2
20.
Tianying Yang Jiawei Li Yichen Jia Chunchen Yang Ruirui Sang Tongyu Zhu Ming Xu Ruiming Rong Cheng Yang 《Translational andrology and urology》2021,10(1):204
BackgroundIn the field of transplantation, inducing immune tolerance in recipients is of great importance. Blocking co-stimulatory molecule using anti-CD28 antibody could induce tolerance in a rat kidney transplantation model. Myeloid-derived suppressor cells (MDSCs) reveals strong immune suppressive abilities in kidney transplantation. Here we analyzed key genes of MDSCs leading to transplant tolerance in this model.MethodsMicroarray data of rat gene expression profiles under accession number in the Gene Expression Omnibus (GEO) database were analyzed. Running the LIMMA package in R language, the differentially expressed genes (DEGs) were found. Enrichment analysis of the DEGs was conducted in the Database for Annotation, Visualization and Integrated Discovery (DAVID) database to explore gene ontology (GO) annotation and their Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Their protein-protein interactions (PPIs) were provided by STRING database and was visualized in Cytoscape. Hub genes were carried out by CytoHubba.ResultsThree hundred and thirty-eight DEGs were exported, including 27 upregulated and 311 downregulated genes. The functions and KEGG pathways of the DEGs were assessed and the PPI network was constructed based on the string interactions of the DEGs. The network was visualized in Cytoscape; the entire PPI network consisted of 192 nodes and 469 edges. Zap70, Cdc42, Stat1, Stat4, Ccl5 and Cxcr3 were among the hub genes.ConclusionsThese key genes, corresponding proteins and their functions may provide valuable background for both basic and clinical research and could be the direction of future studies in immune tolerance, especially those examining immunocyte-induced tolerance. GSE28545相似文献