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991.
Nakanishi C Kawagishi N Sekiguchi S Akamatsu Y Sato K Miyagi S Takeda I Hukushima K Aiso T Sato A Fujimori K Satomi S 《The Tohoku journal of experimental medicine》2007,211(2):195-200
The majority of acute cellular rejection occurs in the first few months after liver transplantation. It has been, however, reported that some recipients experience late acute rejection, which occurs more than 3 months after transplantation. We herein report a case of late acute rejection that occurred nearly 10 years after liver transplantation. The patient is a 27-year-old male who underwent a living donor liver transplantation when he was 17 years old. At 9 years 6 months after transplantation, the patient presented with the elevated serum levels of liver enzymes and total bilirubin. A liver biopsy showed acute cellular rejection. Steroid bolus therapy was not effective, but we successfully used deoxyspergualin as a rescue therapy. Late acute cellular rejection that occurs nearly 10 years after transplantation has so far been rarely reported. It is generally believed that late acute rejection may be more resistant to treatment and be associated with a higher rate of graft loss, as well being associated with the development of chronic ductopenic rejection. In this report, we have shown that deoxyspergualin is safe and effective for treatment of steroid-resistant late acute rejection, preventing from graft loss of chronic rejection. 相似文献
992.
S. Miyagi C. Nakanishi Y. Hara W. Nakanishi K. Tokodai K. Shimizu S. Uematsu H. Kumata Y. Kakizaki M. Goto T. Kamei M. Unno S. Satomi 《Transplantation proceedings》2018,50(9):2611-2613
Objectives
In adults undergoing living donor liver transplantation (LDLT), the transplanted livers are partial grafts, and the portal venous pressure is higher than that observed with whole liver grafts. In patients undergoing LDLT concomitant with splenomegaly, portal venous flow is often diverted to collateral vessels, leading to a high risk of portal vein thrombosis. In such cases, occlusion of the collateral veins is important; however, complete occlusion of all collaterals without blocking the blood flow through the splenic artery causes portal hypertension and liver failure. We aimed to examine the effect of performing a splenectomy concomitant with LDLT to reduce portal vein complications.Methods
Between 1991 and 2017, we performed 170 LDLT operations, including 83 in adults. For this cohort study, adult cases were divided into 2 groups. Group I was those who underwent LDLT without splenectomy (n = 60); Group II was those who underwent LDLT with splenectomy for the reduction of portal hypertension (n = 23). We investigated the incident rates of complications, including blood loss, lethal portal vein thrombosis (intrahepatic thrombosis), acute rejection, and so on. We also investigated the survival rates in both groups.Results
The incident rate of lethal portal vein thrombosis in Group II was significantly lower than that observed in Group I (4.4% vs 21.7%, respectively, P = .0363). There were no statistically significant differences observed between the groups with respect to blood loss, survival rates, and other such parameters.Conclusion
LDLT concomitant with splenectomy might effectively reduce the occurrence of portal vein complications in adults. 相似文献993.
Vein wrapping promotes M2 macrophage polarization in a rat chronic constriction injury model
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Naoya Hirosawa Kentaro Uchida Kazuki Kuniyoshi Kenichi Murakami Gen Inoue Masayuki Miyagi Yusuke Matsuura Sumihisa Orita Kazuhide Inage Takane Suzuki Masashi Takaso Seiji Ohtori 《Journal of orthopaedic research》2018,36(8):2210-2217
994.
995.
Tsutomu?AkazawaEmail authorView authors OrcID profile Toshiaki?Kotani Tsuyoshi?Sakuma Shohei?Minami Yoshiaki?Torii Sumihisa?Orita Kazuhide?Inage Kazuki?Fujimoto Yasuhiro?Shiga Gen?Inoue Masayuki?Miyagi Wataru?Saito Seiji?Ohtori Hisateru?Niki 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2018,28(2):177-181
Purpose
Our previous study reported a good health-related quality of life (HRQOL) in adolescent idiopathic scoliosis (AIS) patients 21 years or more after surgery. The purpose of this study is to investigate midlife changes in HRQOL among AIS patients who passed further 5 years from the previous survey.Methods
Subjects were 252 individuals who underwent spinal fusion for AIS between 1968 and 1988. The survey was administered twice—in 2009 and in 2014 using Scoliosis Research Society Patient Questionnaire (SRS-22). We analysed survey responses from 42 individuals (39 females, 3 males) who responded to both surveys.Results
The average scores for each respective domain of the SRS-22 in 2009 and 2014, respectively, were: function, 4.3 and 4.2; pain, 4.3 and 4.3; self-image, 3.0 and 2.9; mental, 3.9 and 3.8; satisfaction, 3.6 and 3.5. There were no significant differences in any domain of the SRS-22 between 2009 and 2014. Comparing non-fused segments of the lumbar spine of patients with fewer than four discs remaining with patients with four discs or more remaining, SRS-22 satisfaction score decreased more in patients with fewer than four discs (change in patients with four discs or more: ?0.02; change in patients with fewer than four discs: ?0.38; P = 0.05).Conclusion
Each SRS-22 subscore was similar between 2009 and 2014 surveys. Those scoliosis patients who underwent spinal fusion during adolescence had good HRQOL scores in midlife. Even after five years passed, good conditions were maintained.996.
997.
998.
Miyagi Chihiro Miyamoto Takuma Kuroda Taiyo Karimov Jamshid H. Starling Randall C. Fukamachi Kiyotaka 《Heart failure reviews》2022,27(2):595-608
Heart Failure Reviews - Heart failure with preserved ejection fraction (HFpEF) is characterized by diastolic dysfunction and multiple comorbidities. The number of patients is continuously... 相似文献
999.
Anton Mihic Jiao Li Yasuo Miyagi Mark Gagliardi Shu-Hong Li Jean Zu Richard D. Weisel Gordon Keller Ren-Ke Li 《Biomaterials》2014
The goal of cardiac tissue engineering is to restore function to the damaged myocardium with regenerative constructs. Human embryonic stem cell–derived cardiomyocytes (hESC-CMs) can produce viable, contractile, three-dimensional grafts that function in vivo. We sought to enhance the viability and functional maturation of cardiac tissue constructs by cyclical stretch. hESC-CMs seeded onto gelatin-based scaffolds underwent cyclical stretching. Histological analysis demonstrated a greater proportion of cardiac troponin T–expressing cells in stretched than non-stretched constructs, and flow sorting demonstrated a higher proportion of cardiomyocytes. Ultrastructural assessment showed that cells in stretched constructs had a more mature phenotype, characterized by greater cell elongation, increased gap junction expression, and better contractile elements. Real-time PCR revealed enhanced mRNA expression of genes associated with cardiac maturation as well as genes encoding cardiac ion channels. Calcium imaging confirmed that stretched constructs contracted more frequently, with shorter calcium cycle duration. Epicardial implantation of constructs onto ischemic rat hearts demonstrated the feasibility of this platform, with enhanced survival and engraftment of transplanted cells in the stretched constructs. This uniaxial stretching system may serve as a platform for the production of cardiac tissue-engineered constructs for translational applications. 相似文献
1000.
Kyoko Mochizuki Masato Shinkai Hiroshi Take Norihiko Kitagawa Hidehito Usui Fumio Asano Hisayuki Miyagi Kouji Fukumoto 《Pediatric surgery international》2014,30(9):941-944
Type IV laryngotracheoesophageal cleft (LTEC) is a rare congenital anomaly that is associated with high morbidity and mortality despite various forms of surgical repair. This article presents our strategy for surgical management of type IV LTECs using a combination of lateral thoraco-cervical and laryngoscopic approaches. 相似文献