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排序方式: 共有481条查询结果,搜索用时 14 毫秒
51.
Bastard C Bosisio MR Chabert M Kalopissis AD Mahrouf-Yorgov M Gilgenkrantz H Mueller S Sandrin L 《World journal of gastroenterology : WJG》2011,17(8):968-975
AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below ... 相似文献
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Karoui S Laz S Serghini M Bibani N Boubaker J Filali A 《Digestive diseases and sciences》2011,56(6):1801-1805
Background and Aims
Evaluating disease activity is important in ulcerative colitis. Laboratory markers should be a non-invasive alternative to endoscopy for patients. The objective of our study was to scrutinize the correlation between C-reactive protein (CRP) levels and clinical and endoscopic activity in ulcerative colitis patients. 相似文献56.
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Chenik M Douagi F Ben Achour Y Khalef NB Ouakad M Louzir H Dellagi K 《Parasitology research》2005,98(1):5-13
Here, we report the existence of two different mucolipin-like genes in Leishmania parasites. The Leishmania major mucolipin-like A and B genes (lmmlA and lmmlB) encode two proteins of 776 and 590 amino acids, respectively, and may be classified among the mucolipins family [transient receptors potential mucolipin (TRPML)] because (1) they include a large region that exhibits significant similarities with specific domains of ion transport proteins and transient receptors potential (TRP) channels, (2) they contain at least 173 residues that display significant homologies with conserved regions of different mucolipins from several species, and (3) as TRPMLs, they include six predicted transmembrane domains. Gene expression analysis reveals that lmmlB is upregulated in metacyclics and amastigotes relative to procyclics, while lmmlA is constitutively expressed in the three Leishmania developmental stages. These genes could constitute potential drug targets. 相似文献
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