全文获取类型
收费全文 | 13121篇 |
免费 | 1006篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 96篇 |
儿科学 | 522篇 |
妇产科学 | 356篇 |
基础医学 | 1731篇 |
口腔科学 | 103篇 |
临床医学 | 1408篇 |
内科学 | 2668篇 |
皮肤病学 | 206篇 |
神经病学 | 1256篇 |
特种医学 | 460篇 |
外科学 | 1771篇 |
综合类 | 123篇 |
一般理论 | 12篇 |
预防医学 | 1540篇 |
眼科学 | 249篇 |
药学 | 924篇 |
中国医学 | 31篇 |
肿瘤学 | 702篇 |
出版年
2023年 | 172篇 |
2022年 | 231篇 |
2021年 | 583篇 |
2020年 | 365篇 |
2019年 | 529篇 |
2018年 | 561篇 |
2017年 | 412篇 |
2016年 | 396篇 |
2015年 | 394篇 |
2014年 | 562篇 |
2013年 | 650篇 |
2012年 | 1066篇 |
2011年 | 1021篇 |
2010年 | 458篇 |
2009年 | 393篇 |
2008年 | 697篇 |
2007年 | 646篇 |
2006年 | 567篇 |
2005年 | 547篇 |
2004年 | 497篇 |
2003年 | 419篇 |
2002年 | 393篇 |
2001年 | 171篇 |
2000年 | 195篇 |
1999年 | 149篇 |
1998年 | 75篇 |
1997年 | 52篇 |
1996年 | 47篇 |
1995年 | 48篇 |
1994年 | 42篇 |
1993年 | 44篇 |
1992年 | 121篇 |
1991年 | 78篇 |
1990年 | 105篇 |
1989年 | 99篇 |
1988年 | 113篇 |
1987年 | 92篇 |
1986年 | 66篇 |
1985年 | 82篇 |
1984年 | 60篇 |
1983年 | 77篇 |
1981年 | 43篇 |
1979年 | 50篇 |
1978年 | 49篇 |
1975年 | 49篇 |
1974年 | 66篇 |
1972年 | 56篇 |
1971年 | 50篇 |
1970年 | 40篇 |
1967年 | 40篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
12.
Mani N Pavuluri Megan Marlow O'Connor Erin M Harral Melissa Moss John A Sweeney 《Neuropsychopharmacology》2006,60(9):951-956
BACKGROUND: Previous research has demonstrated that academic and neuropsychological functions are compromised in pediatric bipolar disorder (PBD). Investigation of the degree to which neuropsychological deficits might contribute to those academic problems is needed to aid in the recognition and intervention for school achievement difficulties in PBD. METHODS: A sample of 55 children and adolescents with PBD with and without attention-deficit/hyperactivity disorder (ADHD) (PBD group, n = 28; PBD+ADHD group, n = 27) were tested with a computerized neurocognitive battery and standardized neuropsychological tests. Age range of subjects was 7-17 years, with the mean age of 11.97 (3.18) years. Parents completed a structured questionnaire on school and academic functioning. RESULTS: Logistic regression analyses indicated that executive function, attention, working memory, and verbal memory scores were poorer in those with a history of reading/writing difficulties. A separate logistic regression analysis found that attentional dysfunction predicted math difficulties. These relationships between neuropsychological function and academic difficulties were not different in those with PBD+ADHD than in those with PBD alone. CONCLUSIONS: In PBD neuropsychological deficits in the areas of attention, working memory, and organization/problem solving skills all contribute to academic difficulties. Early identification and intervention for these difficulties might help prevent lower academic achievement in PBD. 相似文献
13.
14.
15.
Megan Boitano 《Nutrition in clinical practice》2006,21(6):617-622
During critical illness, the stress response causes accelerated gluconeogenesis and lipolysis, leading to hyperglycemia and elevated serum triglyceride levels. The traditional nutrition support strategy of meeting or exceeding calorie requirements may compound the metabolic alterations of the stress response. Hypocaloric nutrition support has the potential to provide nutrition support without exacerbating the stress response. Studies have shown hypocaloric nutrition support to be safe and to achieve nitrogen balance comparable with traditional regimens. Benefits shown include improved glycemic control, decreased intensive care unit (ICU) length of stay (LOS), and decreased ventilator days and infection rate; however, not all studies have produced identical results. Providing adequate dietary protein has emerged as an important factor in efficacy of the hypocaloric regimen. Although it is inconclusive, currently available research suggests that a nutrition support goal of 10-20 kcal/kg of ideal or adjusted weight and 1.5-2 g/kg ideal weight of protein may be beneficial during the acute stress response. Well-designed, randomized, controlled studies with adequate sample size that evaluate relevant clinical outcomes such as mortality, ICU LOS, and infection while controlling for factors such as glycemic control, severity of illness, incorporation of calories from all sources, in addition to feeding regimens, are needed to definitively determine the effects of hypocaloric nutrition support. 相似文献
16.
Pharmacokinetics and pharmacodynamics of benazepril hydrochloride in patients with major proteinuria
Ch. Schweizer G. Kaiser W. Dieterle J. Mann 《European journal of clinical pharmacology》1993,44(5):463-466
Summary We have investigated whether the pharmacokinetics and pharmacodynamics of the ACE inhibitor benazepril hydrochloride are altered with proteinuria by studying 8 patients with major proteinuria of different causes who were given a single dose of 10 mg p.o.The maximum plasma concentration of benazepril was found between 0.5 and 2 h after dosing (median 1 h). Its elimination was almost complete within 6 h. Peak plasma levels of benazeprilat, the active metabolite of benazepril, were observed between 1 and 6 h (median 2.5 h). The elimination of benazeprilat from plasma was biphasic, with mean initial and terminal half-lives of 3.0 and 17.3 h, respectively. On average, the pharmacokinetic parameters of benazepril and benazeprilat in the patients did not differ from those in a historical control group of healthy volunteers, but intersubject variability in the AUC and half-lives of benazeprilat was greater in the patients.Plasma ACE was completely inhibited from 1.5 to 6 h after dosing, and at 48 h the mean inhibition was still 42 %. Plasma renin showed substantial intersubject variation. Mean supine blood pressure (systolic/diastolic) was reduced from baseline by a maximum of 18/13 mm Hg at 6 h. Proteinuria was diminished after benazepril in 7 patients.In conclusion, the results of this study suggest that proteinuria in the nephrotic range does not require a change in benazepril dosage. 相似文献
17.
Pharmacological properties of fluphenazine-mustard, an irreversible calmodulin antagonist 总被引:1,自引:0,他引:1
We describe an improved synthesis and properties of fluphenazine-mustard, a potent phenothiazine having an alkylating chlorethylamine chain in its structure. The drug possesses anticalmodulin activity equivalent to the parent compound, but unlike fluphenazine dihydrochloride, the mustard derivative irreversibly antagonizes the ability of calmodulin to activate cyclic nucleotide phosphodiesterase. This property is partially calcium-dependent and can be overcome by coincubation with excess fluphenazine dihydrochloride. The compound irreversibly inactivated calmodulin when incubated with intact cells and caused single-stranded breakage of DNA. Fluphenazine-mustard possesses potent antiproliferative and cytotoxic properties against malignant cell lines that are likely to be mediated through both of these actions. 相似文献
18.
McArdle's disease with myoadenylate deaminase deficiency: observations in a combined enzyme deficiency 总被引:1,自引:0,他引:1
Exercise and work potential of a patient with coexistent myophosphorylase and myoadenylate deaminase (AMPDA) deficiency was compared with that of three patients with myophosphorylase deficiency alone. The patient with the combined defect failed to produce an abnormal rise in serum ammonia or hypoxanthine as seen in the other patients after forearm exercise. Maximum oxygen consumption and work rates during cycle ergometer testing were similar in all patients, but well below controls. The occurrence of two defects involving short-term energy metabolism in muscle presents an opportunity to define further the metabolic role of AMPDA. 相似文献
19.
20.
Megan A. O’Grady Kristina Wilson Jennifer J. Harman 《The journal of primary prevention》2009,30(6):716-731
The purpose of this study was to evaluate a single-session peer-led safer sex intervention, based on the Information-Motivation-Behavioral
Skills theoretical model, for college students residing in campus residence halls. Participants (N = 108) were assigned to either an hour long control or 5-module intervention session. Compared to the control condition,
the intervention increased participants’ information and women’s subjective norms about preventative behavior. Both the control
and intervention sessions increased intentions to perform preventative behaviors (e.g., keep condoms available). These preliminary
results suggest that this intervention is promising for increasing constructs associated with safer sexual behavior and could
easily be implemented by residence hall staff. 相似文献