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61.
Lina Nordquist Malou Friederich-Persson Angelica Fasching Per Liss Kumi Shoji Masaomi Nangaku Peter Hansell Fredrik Palm 《Journal of the American Society of Nephrology : JASN》2015,26(2):328-338
Hyperglycemia results in increased oxygen consumption and decreased oxygen tension in the kidney. We tested the hypothesis that activation of hypoxia-inducible factors (HIFs) protects against diabetes-induced alterations in oxygen metabolism and kidney function. Experimental groups consisted of control and streptozotocin-induced diabetic rats treated with or without chronic cobalt chloride to activate HIFs. We elucidated the involvement of oxidative stress by studying the effects of acute administration of the superoxide dismutase mimetic tempol. Compared with controls, diabetic rats displayed tissue hypoxia throughout the kidney, glomerular hyperfiltration, increased oxygen consumption, increased total mitochondrial leak respiration, and decreased tubular sodium transport efficiency. Diabetic kidneys showed proteinuria and tubulointerstitial damage. Cobalt chloride activated HIFs, prevented the diabetes-induced alterations in oxygen metabolism, mitochondrial leak respiration, and kidney function, and reduced proteinuria and tubulointerstitial damage. The beneficial effects of tempol were less pronounced after activation of HIFs, indicating improved oxidative stress status. In conclusion, activation of HIFs prevents diabetes-induced alteration in kidney oxygen metabolism by normalizing glomerular filtration, which reduces tubular electrolyte load, preventing mitochondrial leak respiration and improving tubular transport efficiency. These improvements could be related to reduced oxidative stress and account for the reduced proteinuria and tubulointerstitial damage. Thus, pharmacologic activation of the HIF system may prevent development of diabetic nephropathy. 相似文献
62.
Christina Stadler Christine M. Freitag Arne Popma Lucres Nauta-Jansen Kerstin Konrad Eva Unternaehrer Katharina Ackermann Anka Bernhard Anne Martinelli Helena Oldenhof Malou Gundlach Gregor Kohls Martin Prätzlich Meinhard Kieser Ronald Limprecht Nora M. Raschle Noortje Vriends Robert L. Trestman Marietta Kirchner Linda Kersten 《Journal of child psychology and psychiatry, and allied disciplines》2024,65(3):316-327
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Hugo J.A. Adams Thomas C. Kwee Malou A. Vermoolen Inge Ludwig Marc B. Bierings Rutger A.J. Nievelstein 《European journal of radiology》2014
Objective
To assess and compare patient experience of whole-body magnetic resonance imaging (MRI) to that of computed tomography (CT) for staging newly diagnosed lymphoma.Materials and methods
A total of 36 patients with newly diagnosed lymphoma prospectively underwent whole-body MRI and CT for staging purposes. Patients were asked to fill in a short questionnaire with regard to the burden and experience of the examination on a Likert scale (range 1–4). Wilcoxon signed rank tests were used to determine statistically significant differences in patient (dis)comfort between the two examinations.Results
Patients reported to be significantly (P = 0.007) less worried before undergoing whole-body MRI compared to CT. Patients also experienced whole-body MRI as significantly (P = 0.010) less unpleasant and felt significantly (P = 0.003) better shortly after the scan. The necessary preparations before CT scanning (i.e. insertion of intravenous line, drinking of contrast fluid), which are not required for whole-body MRI, were reported to be a considerable burden.Conclusion
In this study in patients with newly diagnosed lymphoma, whole-body MRI was experienced as a more patient-friendly technique than CT. 相似文献64.
Katrine Laura Rasmussen Malou Philips Armando Tripodi Jens Peter Goetze 《European journal of haematology》2020,104(6):519-525
A common inquiry in coagulation laboratories is how to interpret an unexpected, isolated prolonged activated partial thromboplastin time (APTT). In this context, isolated means together with a normal prothrombin time (PT) and/or normal international normalized ratio (INR). This finding may lead to contact with laboratory doctors for further advice on a diagnostic strategy. Occasionally, the need for a diagnostic algorithm can be subacute, where surgery has to be postponed until an explanation for the isolated, prolonged APTT has been established. Activated partial thromboplastin time as a coagulation test was developed to monitor patients with hemophilia. Different APTT reagents display considerable differences in their sensitivity to deficiencies of coagulation factors. An isolated, prolonged APTT is seen in (a) individuals/patients with lupus anticoagulants, (b) patients in treatment with anticoagulants, mainly heparin, and (c) patients with deficiencies of specific coagulation factors. In this tutorial review, we summarize what may cause an isolated prolonged APTT and we present a simple diagnostic algorithm to differentiate between lupus anticoagulants (common) and factor deficiencies (rare). The identification of an isolated prolonged APTT as well as the underlying cause can be of the utmost importance in ensuring the correct therapeutic follow-up. 相似文献
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Shelagh Redmond Erik von Elm Anette Blümle Malou Gengler Thomas Gsponer Matthias Egger 《Journal of clinical epidemiology》2013,66(12):1367-1375
ObjectivesTo identify factors associated with discrepant outcome reporting in randomized drug trials.Study Design and SettingCohort study of protocols submitted to a Swiss ethics committee 1988–1998: 227 protocols and amendments were compared with 333 matching articles published during 1990–2008. Discrepant reporting was defined as addition, omission, or reclassification of outcomes.ResultsOverall, 870 of 2,966 unique outcomes were reported discrepantly (29.3%). Among protocol-defined primary outcomes, 6.9% were not reported (19 of 274), whereas 10.4% of reported outcomes (30 of 288) were not defined in the protocol. Corresponding percentages for secondary outcomes were 19.0% (284 of 1,495) and 14.1% (334 of 2,375). Discrepant reporting was more likely if P values were <0.05 compared with P ≥ 0.05 [adjusted odds ratio (aOR): 1.38; 95% confidence interval (CI): 1.07, 1.78], more likely for efficacy compared with harm outcomes (aOR: 2.99; 95% CI: 2.08, 4.30) and more likely for composite than for single outcomes (aOR: 1.48; 95% CI: 1.00, 2.20). Cardiology (aOR: 2.34; 95% CI: 1.44, 3.79) and infectious diseases (aOR: 1.77; 95% CI: 1.01, 3.13) had more discrepancies compared with all specialties combined.ConclusionDiscrepant reporting was associated with statistical significance of results, type of outcome, and specialty area. Trial protocols should be made freely available, and the publications should describe and justify any changes made to protocol-defined outcomes. 相似文献
68.
Endogenous retroviral genetic material serves as a reservoir for the generation of retroviral pathogens by recombination between activated endogenous or exogenous infectious agents. Some porcine tissues actively express infectious porcine endogenous retroviruses (PERVs). Of the three classes of PERV characterized to date, two, PERV-A and B, are capable of infecting human cells in vitro, whereas PERV-C cannot. Here, we demonstrate that the PERV-C envelope surface protein (SU) when disassociated from its C-terminus binds human cells. Further, we show that PERV-C binding to human cells is not inhibited in 293 cells productively infected with PERV-A, confirming that the molecule PERV-C interacts with on human cells is distinct from that used by PERV-A. Moreover, we demonstrate that the envelope region encompassing the proline-rich region is required for binding to cells in addition to the putative variable region A (VRA) and B (VRB). The region in the C-terminus of the SU that alters the binding and infectivity properties of PERV-C differs by only nine residues from the analogous region of PERV-A. Caution may be warranted even when a xenotransplantation product is from source pigs that do not express human-tropic viruses, as minimal mutations within PERV-C combined with selection in a human recipient could render PERV-C infectious in humans. 相似文献
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Malou Heijligers Aafke van Montfoort Madelon Meijer-Hoogeveen Frank Broekmans Katelijne Bouman Irene Homminga Jos Dreesen Aimee Paulussen John Engelen Edith Coonen Vyne van der Schoot Marieke van Deursen-Luijten Nienke Muntjewerff Andrea Peeters Ron van Golde Mark van der Hoeven Yvonne Arens Christine de Die-Smulders 《Journal of assisted reproduction and genetics》2018,35(11):1995-2002