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981.
NGF促再生神经功能恢复的实验研究 总被引:3,自引:0,他引:3
目的 运用电生理、类霍乱毒 -辣根过氧化物酶 (CB-HRP)逆行追踪的方法 ,研究神经生长因子 (nerve growth factorNGF)对再生神经功能恢复的影响。方法 Wistar大白鼠 2 0只 ,切断两侧位于股骨中段的坐骨神经 ,硅胶管桥接形成神经再生小室 ,断端相距 6 mm。右侧再生小室内注入 NGF,左侧注入等量的生理盐水 ,分笼饲养 3个月。结果 NGF侧电生理数值 :L AT:(2 .0 8±0 .42 ) ms,CV:(35 .9± 8.6 7) m/s,AMP:(6 .18± 2 .90 ) mv± 0 .48) mv,各项指标两组数值标本均数的 t检验 P<0 .0 1。CB-HRP逆行追踪 ,被 CB-HRP标记的运动细胞数 NFG侧 :(4.2± 0 .974) ,NS侧 :(2 .3± 0 .483) ,两组数值样本均数的 t检验 P<0 .0 1。结论 通过电生理及 CB-HRP逆行追踪证实 ,NGF有促进再生神经功能恢复的作用 相似文献
982.
983.
合欢皮对小鼠免疫功能的调节作用 总被引:4,自引:0,他引:4
目的 探讨合欢皮对小鼠免疫功能的影响。方法 用相当于生药10mg/(kg.d)、100mg/(kg.d)和500mg/(kg.d)合 皮水提取液,连续小鼠灌胃6d,检测小鼠腹腔巨噬细胞对鸡红细胞(CRBC)的吞噬率和吞噬指数,刀豆素A(ConA)刺激小鼠腹腔巨噬细胞肿瘤坏死因子(TNF)和脾淋巴细胞白细胞介素-2(IL-2)诱生的水平。结果 100mg/(kg.d)合欢皮使小鼠腹腔巨噬细胞的吞噬率 相似文献
984.
Yi-Fei Zhang Jing-Jing Guo Fan Yang Hang-Yu Zhou Na-Na Zhang Xiao-Chuan Xiong Yue Feng Yong-Qiang Deng Cheng-Feng Qin 《Journal of medical virology》2023,95(1):e28290
The geographic range of Zika virus (ZIKV) has expanded from Asia to the Americas, leading to the 2015–2016 pandemic with enhanced neurovirulence. At present, ZIKV is continuously circulating in many Southeast Asian countries. Unfortunately, the persistent evolution of ZIKV in Southeast Asia and its influence on the biological characteristics of the virus remain incompletely understood. In this study, the in vitro and in vivo properties of a new ZIKV isolate obtained from Cambodia in 2019 (CAM/2019) were characterized and compared with those of the Cambodian strain (CAM/2010). Compared with CAM/2010, the CAM/2019 virus showed similar plaque morphology and growth curves in cell cultures and induced comparable viremia and organ viral loads profiles in both BALB/c and A129 (IFNAR1−/−) mice upon intraperitoneal (i.p.) inoculation. Remarkably, the CAM/2019 virus exhibited enhanced neurovirulence in neonatal mice compared with CAM/2010, with a 74-fold reduction in the 50% lethal dose (LD50). Consistently, CAM/2019 produced higher viral loads in the brains of BALB/c neonatal mice than CAM/2010 did. Sequence alignment showed that the CAM/2019 virus has acquired 12 amino acid substitutions, several of which were found to be associated with neurovirulence. In particular, the CAM/2019 virus shared an A1204T substitution in NS2A with the Thai isolate SI-BKK02 that was isolated from a microcephaly case. Taken together, our results indicate that a ZIKV strain isolated with specific mutations has emerged in Cambodia, highlighting the need for extensive molecular and disease surveillance in Cambodia and other Asian countries. 相似文献
985.
Fan Wu Yue Yuan Yanjun Li Di Yin Bing Lang Yangguo Zhao Xueying Fan Huachun Zou Chunhuan Zhang Xiangyue Zeng Caijun Sun 《Journal of medical virology》2023,95(1):e28227
Compared with the nucleic acid amplification test (NATT), the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapid antigen self-testing (RAST) has advantages in speed and convenience. However, little is known about people's acceptance and influencing factors for SARS-CoV-2 RAST. A cross-sectional study was conducted from April 21 to 30, 2022 in China. The χ2 test and multivariate logistic regressions were used to identify the influencing factors. The structural equation model was used to test the extended protective motivation theory (PMT) model hypotheses. Among the total of 5107 participants, 62.5% were willing to accept the SARS-CoV-2 RAST. There were significant differences in acceptance among different residences (p < 0.001), educational level (p < 0.001), occupation (p < 0.001), monthly income (p < 0.001), travel frequency (p < 0.05), and feelings about NATT (p < 0.001). Response efficacy (β = 0.05; p = 0.025) and self-efficacy (β = 0.84; p < 0.001) had a positive effect, while response cost showed a negative effect (β = −0.07; p < 0.001). The public's major concerns about SARS-CoV-2 RAST are its reliability, testing method, price, and authority. Overall, a moderate intention to use SARS-CoV-2 RAST was found among the Chinese population. The extended PMT can be used for the prediction of intention to accept the RAST. We need to take measures to increase people's acceptance of SARS-CoV-2 RAST. 相似文献
986.
The abeted in Colo~ cancer gene (DCC) is re~ as a susceptibility gene in colol'eCtal cancer, whichis located on chlomesome 18qZI. 2. Ihactivation of thisgene may Play an i~ role dndng some Pimessessuch as ~ p~ssion and metastasis. With its ~allycloned, in lop, casinger et alllJ found that a vocablenumber tandem repeat (VNTR) is located wick an intwOf the DCC gene, its lepeat act is 2 hp,the core seqUence of (TA)n ~ numbers ~ 10 -- to tinies, whichis an ideal genetic rnalker. Esophageal… 相似文献
987.
目的:探讨^99mTc-DTPA-甲硝唑在正常动物的体内分布。方法:经小鼠和家兔耳缘静脉注射^99mTc-DPTA-甲硝唑(3.7MBq)后5min24h,连续采集血液和其它脏器标本,测其放射性。结果:^99mTc-DTPA-甲硝唑正常小鼠生物分布除肝脏、肾脏外,其余器官无明显分布。家兔血液清除研究在血中清除快,在血中呈双指数下降T1/2α为0.45h,T1/2β为3.18h。结论:^99mTc- 相似文献
988.
989.
聚乳酸酮洛芬微球的制备及其体外释放度 总被引:5,自引:0,他引:5
制备了生物可降解的材料聚乳酸,用粘度法测定其分子量,并选用A、B、C三种不同分子量的聚乳酸为药物的载体,制备了酮洛芬微球(AS,BS,CS),测定其粒径和体外溶出速率。结果表明催化剂四苯基锡用量增加,所得的聚乳酸分子量增加,而制备酮洛芬微球的聚乳酸分子量越大,其微球粒径越大,溶出速率越小。 相似文献
990.
岳文浩 《山东医科大学学报(社会科学版)》2000,(2)
20世纪诺贝尔医学奖中奖项目 98项中可看出基础医学中奖项目多于临床 ,为 80∶2 0 ;美国人中奖最多 ,英、德领先 ;中奖科学家出身名校并受名师潜移默化 ;医学发展极快 ,2 0世纪下半叶中奖项目难度大、知识面广 ,跨学科、多人合作、智慧科技含量高。为此我国在 2 1世纪的医学教育必须加大投入、重建师资队伍、教学内容及方法不断更新、重视基础医学及人文社会科学、培养学生求异创新思维、更新科技研究水平 ,加大国际交流并结合我国医学优势及需要必定能获得 2 1世纪诺贝尔奖 相似文献