鼻咽癌组织中Survivin蛋白和HIF-1α表达水平及临床意义

目的 探讨鼻咽癌组织中Survivin蛋白和缺氧诱导因子-1α(HIF-1 α)表达水平及临床意义.方法 选取2010年12月-2015年12月经病理切片确诊为鼻咽癌的患者72例;同时选取24例慢性鼻咽炎组织标本进行对照.应用免疫组织化学检测Survivin蛋白和HIF-1α的表达情况,并分析其表达水平的临床意义.结果 鼻咽癌组织中Survivin蛋白和HIF-1α阳性表达率均高于慢性鼻咽炎组织(P＜ 0.001).Ⅲ+Ⅳ期鼻咽癌组织Survivin蛋白和HIF-1α的阳性表达率、中等及以上阳性表达率均高于Ⅰ+Ⅱ期鼻咽癌组织(P ＜0.001);有淋巴结转移的患者Survivin蛋白和HIF-1α的阳性表达率均高于无淋巴结转移的患者(P＜0.05和P＜0.001).结论 Survivin和HIF-1α表达在鼻咽癌组织中具有较高的表达,两者在鼻咽癌的分期,进展过程中起到了重要的作用.     

李发枝教授艾滋病发热医案数据挖掘分析

目的：分析李发枝教授治疗艾滋病发热的用药规律,为中医药治疗艾滋病发热提供相应的用药参考依据。方法：利用复杂网络分析方法,研究河南尉氏县2007 年9 月~2012 年6 月期间接受李发枝教授治疗过的艾滋病发热患者,分析艾滋病发热的病因病机、名老中医辨证论治及用药规律。结果：运用多维检索查询分析得出,本次研究中治疗艾滋病发热的核心药物为柴胡、甘草、黄芩等和解清热药物及党参、黄芪等益气扶正之品;核心处方为小柴胡汤和补中益气汤加减。结论：李发枝教授治疗艾滋病发热以清热兼补中益气为治则。     

Effect of Bi,Sb, and Ti on Microstructure and Mechanical Properties of SAC105 Alloys

The Sn-Ag-Cu (SAC) solder alloys with a low Ag (Ag < 3 wt.%) content have attracted great attention owing to their low cost, increased ability in bulk compliance, and plastic energy dissipation. However, some of their mechanical properties are generally lower than the SAC alloys with a higher Ag content. Adding alloying elements is an effective approach for improving the mechanical properties of the SAC alloys. In this study, the effect of Bi, Sb, and Ti on Sn-1 wt.%Ag-0.5 wt.%Cu (SAC105) solder alloys was investigated. The SAC solders with four compositions: SAC105-1 wt.%Bi, SAC105-1 wt.%Sb, SAC105-1 wt.%Bi-1 wt.%Sb, SAC105-1 wt.%Bi-1 wt.%Sb-0.4 wt.%Ti were prepared. The microstructure and phase compositions were characterized using electron scanning microscopy, and X-ray diffraction. The thermal properties and wettability were also examined. Uniaxial tensile tests and nano-indentation tests were conducted to evaluate the mechanical properties. The results show that adding Bi or Sb could increase the strength of SAC105 alloys mainly due to the solid solution strengthening effect. The creep resistance of SAC105 alloys was also improved with the additions of Bi and Sb. The co-additions of Bi and Sb into SAC105 alloys exhibit an enhanced creep resistance than that calculated by the theoretical calculation. The further addition of Ti into SAC105-1Bi-1Sb alloys demonstrated a much-improved creep resistance, which could be attributed to the synergistic effects of both solid solution strengthening and the precipitation hardening effects.     

炔雌醇环丙孕酮片治疗多囊卵巢综合征临床分析

目的：探讨炔雌醇环丙孕酮片治疗多囊卵巢综合征（PCOS）的临床效果。方法：选择本院收治的66例多囊卵巢综合征患者,全部PCOS患者都从撤药流血或者月经流血第5天起,每天晚上服用1片炔雌醇环丙孕酮片,连续服用21d。然后在撤药撤血第5天开始重复使用炔雌醇环丙孕酮片,共使用6个周期。观察治疗前后体征参数、性激素水平和血糖代谢水平。结果：多囊卵巢综合征患者在治疗后,多毛体征和痤疮严重程度大为减轻,而且卵巢的体积显著减小,黄体生成素、黄体生成素/空腹胰岛素、总睾酮均显著下降（P〈0.05）,血糖代谢不受影响（P〉0.05）。治疗前正常排卵者3例,治疗后正常排卵者45例。结论：炔雌醇环丙孕酮片对多囊卵巢综合征患者有显著的抗激素作用,对血糖代谢无不良影响,促进排卵,能显著降低雄激素和相关体征。     

中医儿科学本科专业实施导师制的问题及对策

本科生导师制是立德树人背景下高校教学改革的重要举措,现已逐渐成为高等医学教育的大趋势.作为新增专业,中医儿科学在实施本科生导师制方面也进行了探索,从目前中医儿科学实施本科生导师制的必要性、存在的问题及对策进行了探讨,以期为更好地实施导师制、提高人才培养质量提供参考.     

抗核小体抗体与抗dsDNA抗体在系统性红斑狼疮及狼疮肾炎诊断中的意义

目的 探讨抗核小体抗体(AnuA)和抗dsDNA抗体在狼疮肾炎(LN)诊断中的价值.方法 对98例LN患者(LN组)和79例非LN的系统性红斑狼疮(SLE)患者(非LN组)采用酶联免疫吸附(ELISA)法检测AnuA和ds-DNA抗体,并进行比较.两组标本行抗Sm抗体、抗nRNP抗体、抗核糖体P蛋白和抗中性粒细胞胞浆抗体(ANCA)检测,并进行相关性分析.结果 LN组患者血清中AnuA和抗dsDNA抗体的阳性率分别为63.69％和67.86％,非LN组阳性率分别为44.21％和51.39％,LN组阳性率明显高于非LN组(P＜0.05).LN组与非LN组和ANCA比较,差异有统计学意义(P＜0.05),抗SM抗体抗nRNP抗体和抗核糖体P蛋白比较,差异无统计学意义(P＞0.05).结论 AnuA和抗dsDNA抗体可作为诊断SLE的指标,其与SLE患者发生LN密切相关.同时检测多种自身抗体有助于诊断SLE和LN.     

双旋转皮瓣应用于乳腺癌保留乳房治疗的临床研究

目的：研究拓宽乳腺癌保留乳房治疗的指征及改善术后美容效果的手术方法。方法：对65例临床T1-3N0-2M。乳腺癌患者行肿瘤切除＋全腋淋巴结清除术,达到切缘阴性,术中采用双旋转乳腺皮瓣进行乳腺整形,辅以放、化和（或）内分泌治疗。结果：65例清除腋窝淋巴结8～26枚／例,平均16枚／例,术后中位随访时间为68个月,均无局部复发,3、5、8年生存率分别为100％、91．67％和86．67％。保留乳房的美容效果满意率为95．38％。结论：采用双旋转乳腺皮瓣行乳腺癌保留乳房手术,可以拓宽乳腺癌保留乳房治疗的指征,提高术后美容效果的满意度,不降低肿瘤局部控制率及生存率。     

慢性心力衰竭患者血浆氨基末端脑钠素前体水平对病情的评估

目的探讨氨基末端脑钠素前体(NT-proBNP)水平对慢性心力衰竭患者病情评估的临床价值.方法选择慢性心力衰竭患者135例,以NYHA方法评估其心功能,部分患者行超声心动图检查测定左室射血分数(LVEF);采用ELISA法测定NT-proBNP水平,放射免疫法测定肾素-血管紧张素-醛固酮系统激素水平.结果随着心功能级别增高,NT-proBNP 水平递增,Ⅰ级(1例)、Ⅱ级(47例)、Ⅲ级(65例 )和Ⅳ级(22例 )的NT-proBNP 水平分别为61、746 、1668 和4720 ng/L.各级间均差异有统计学意义(P<0.01).血管紧张素原、肾素、血管紧张素Ⅱ及醛固酮的血浆水平,随心功能或LVEF变化不显著或无规律性.结论NT-proBNP水平对于慢性心力衰竭患者的病情评估具有较高的价值,且优于肾素-血管紧张素-醛固酮系统激素.     

撬拨复位空心钉内固定治疗跟骨舌状骨折

目的探讨撬拨复位空心钉内固定治疗跟骨舌状骨折的临床意义。方法对31例39侧跟骨舌状骨折,行闭合撬拨复位空心钉内固定术。结果全部病例得到随访,平均随访22个月,根据Maryland评分系统进行术后功能评价。优18足,良16足,可3足,差2足,优良率87．2％。结论跟骨舌状骨折行撬拨复位空心钉内固定可以较好复位,固定可靠,早期开始功能锻炼,疗效满意。     

An association of elevated serum prolactin with phthalate exposure in adult men

Objective To investigate the associations of hormone circulation with phthalate exposure in adult men. Methods Semen and serum samples were collected from 118 men who were suspected of infertility. Phthalate diesters including dibutyl phthalate (DBP) and diethylhexyl phthalate (DEHP) in both semen and serum samples were measured, along with serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), estradiol (E 2 ) and prolactin (PRL). Results Serum PRL was positively as...