补脾和胃泄浊法联合常规西药治疗早中期慢性肾功能不全脾虚湿盛证临床研究

目的：观察补脾和胃泄浊法治疗早中期慢性肾功能不全脾虚湿盛证的临床疗效。方法：选择94例早中期慢性肾功能不全患者,按随机数字表法分为对照组和观察组各47例。对照组给予常规西药治疗,观察组在对照组基础上给予补脾和胃泄浊法治疗。评价2组临床疗效,比较2组治疗前后中医证候评分、肾功能、肾血流变化、炎症因子水平及免疫功能。结果：观察组总有效率为89.36%,高于对照组72.34%(P<0.05)。治疗后,2组各项中医证候评分低于治疗前(P<0.05),且观察组各项中医证候评分低于对照组(P<0.05)。治疗后,2组血肌酐(SCr)、尿素氮(BUN)、胱抑素C (Cys-C)、β₂-微球蛋白(β₂-MG)、白细胞介素-6 (IL-6)、C-反应蛋白(CRP)及免疫球蛋白抗体G (IgG)水平较治疗前降低,且观察组低于对照组(P<0.05);2组肾小球滤过率(e GFR)、补体C3水平较治疗前升高,且观察组高于对照组(P<0.05)。治疗后,观察组平均灌注强度(Imix)、血流速度(Vmix)高于治疗前和对照组(P<0....     

安脑片联合奥拉西坦治疗脑卒中后血管性痴呆热毒内盛证临床研究

目的：观察安脑片联合奥拉西坦治疗脑卒中后血管性痴呆（VD）热毒内盛证的临床疗效。方法：按随机数字表法将100例脑卒中后VD热毒内盛证患者分为治疗组与对照组,每组50例。对照组采用奥拉西坦治疗,治疗组给予安脑片联合奥拉西坦治疗,2组均治疗4周。比较2组临床疗效与不良反应发生率。采用美国国立卫生研究院卒中量表（NIHSS）、简易智能精神状态检查量表（MMSE）、临床痴呆评定量表（CDR）、日常生活活动能力量表（ADL）评估神经功能、认知功能、痴呆程度和日常生活活动能力;比较双侧大脑中动脉（MCA）、基底动脉（BA）、大脑前动脉（ACA）、椎动脉（VA）平均血流速度,以及血清脑源性神经营养因子（BDNF）、血管内皮生长因子（VEGF）水平。结果：治疗后,治疗组临床疗效总有效率96.00%,高于对照组82.00%(P<0.05)。治疗后,2组NIHSS、CDR评分均较治疗前降低（P<0.05）,MMSE、ADL评分均较治疗前升高（P<0.05）;治疗组NIHSS、CDR评分均低于对照组（P<0.05）,MMSE、ADL评分均高于对照组（P<0.05）。治疗后,2组...     

Analgesic Effects of Ultrasound‐Guided Iliohypogastric/Ilioinguinal Nerve Block Combined with Lateral Femoral Cutaneous Nerve Block in Total Hip Arthroplasty via Direct Anterior Approach: A Retrospective Cohort Study

ObjectiveThis study aimed to explore the efficacy and safety of the combination of lateral femoral cutaneous nerve blocks (LFCNB) and iliohypogastric/ilioinguinal nerve blocks (IHINB) on postoperative pain and functional outcomes after total hip arthroplasty (THA) via the direct anterior approach (DAA).MethodsIn this retrospective cohort study, patients undergoing THA via the DAA between January 2019 and November 2019 were stratified into two groups based on their date of admission. Sixty‐seven patients received LFCNB and IHINB along with periarticular infiltration analgesia (PIA) (nerve block group), and 75 patients received PIA alone (control group). The outcomes included postoperative morphine consumption, postoperative pain assessed using the visual analogue scale (VAS), the QoR‐15 score, and functional recovery measured as quadriceps strength, time to first straight leg rise, daily ambulation distance, and duration of hospitalization. The Oxford hip score and the UCLA activity level rating were assessed at 1 and 3 months after surgery. In addition, postoperative complications were recorded. Patients were also compared based on the type of incision used during surgery (traditional longitudinal or “bikini” incision).ResultsPatients in the nerve block group showed significantly lower postoperative morphine consumption, lower resting VAS scores within 12 h postoperatively, lower VAS scores during motion within 24 h postoperatively, and better QoR‐15 scores on postoperative day 1. These patients also showed significantly better functional recovery during hospitalization. At 1‐month and 3‐month outpatient follow up, the two groups showed no significant differences in Oxford hip score or UCLA activity level rating. There were no significant differences in the incidence of postoperative complications. Similar results were observed when patients were stratified by type of incision, except that the duration of hospitalization was similar.ConclusionCompared to PIA alone, a combination of LFCNB and IHINB along with PIA can improve early pain relief, reduce morphine consumption, and accelerate functional recovery, without increasing complications after THA via the DAA.     

Comparison of the anxiety,depression and their relationship to quality of life among adult acute leukemia patients and their family caregivers: a cross-sectional study in China

Quality of Life Research - To compare the anxiety, depression and explore their relationship to quality of life (QoL) among adult acute leukemia (AL) patients and family caregivers (FCs) in China....     

Soil microbial activities and carbon and nitrogen fixation

Soil microbial activity that reflects microbiological processes of soil microorganisms is the potential indicator of soil quality, as plants rely on soil microorganisms to mineralize organic nutrients for growth and development. Soil microorganisms also process plant litter and residues into soil organic matter, a direct and stable reservoir of carbon and nitrogen that consists of living and dead organic materials subject to rapid biological decomposition. In natural systems, the action of soil microorganisms is a major determinant of efficient nutrient cycling. This paper reviews the current state of knowledge on the fate of soil microorganisms in terms of carbon and nitrogen fixation.     

Surface modification of titanium implant by microarc oxidation and hydrothermal treatment

Surface modification of titanium implant is processed by microarc oxidation and hydrothermal treatment. A porous surface with a biologically active bone-like apatite layer was formed. The apatite layer consists of very fine crystals and high crystallinity and is integrated with the titanium alloy substrate with a graded structure without a distinct interface. Such a bioactive layer is expected not only to enhance the bony ingrowth into the porous structure, but also to improve the interlocking between implant and bone.     

安宫牛黄丸治疗基底节区脑出血患者颅内高压疗效观察及对血清B 型钠尿肽水平的影响

目的：观察安宫牛黄丸治疗基底节区脑出血患者颅内高压疗效及对氧化应激指标以及血清B 型钠 尿肽（BNP） 水平的影响。方法：选取80 例痰热内闭证基底结节区脑出血患者,按随机数字表法分为观察组 及对照组各40 例,对照组接受脑出血颅内高压常规方案治疗,观察组在对照组基础上联合安宫牛黄丸治疗。 比较2 组治疗前后颅内压（ICP）、平均动脉压（MAP）、心率（HR）、中医证候积分、总抗氧化能力（T-Aoc）、超氧 化物歧化酶（SOD） 以及BNP 水平的变化。结果：治疗后,2 组ICP、MAP 水平均较治疗前下降（P＜0.05）, HR 水平均较治疗前上升（P＜0.05）;观察组ICP、MAP 水平均低于对照组（P＜0.05）,HR 水平高于对照 组（P＜0.05）。治疗后,剧烈头痛、动作迟缓、嗜睡中医证候积分均较治疗前下降（P＜0.05）,观察组上述 3 项中医证候积分均低于对照组（P＜0.05）。治疗后,2 组T-Aoc、SOD 水平均较治疗前上升（P＜0.05）,BNP 水平均较治疗前下降（P＜0.05）;观察组T-Aoc、SOD 水平均高于对照组（P＜0.05）,BNP 水平低于对照 组（P＜0.05）。结论：安宫牛黄丸治疗痰热内闭证基底节区脑出血患者,能有效改善颅内高压,缓解氧化应激 反应,促进心脏功能的恢复。     

孕妇血清标记物在中孕筛查中的应用

目的 :通过对孕妇血清标记物甲胎蛋白 (AFP)和人绒毛膜促性腺激素 ( β -HCG )测定来筛选缺陷儿。 方法 :用放射免疫法对 6 2例孕 14～ 2 3周妊娠妇女上述标记物连测 3次 ,每次隔 12～ 14d ,以两次异常为高危个体。每例筛查者跟踪至胎儿出生后。结果 :在筛查中发现了 1例先天愚型和 1例无脑儿。结论 :上述两种血清标记物可以作为神经管缺陷和先天愚型筛查的一项常规方法