Safety and efficacy of anti-EGFR monoclonal antibody (SCT200) as second-line therapy in advanced esophageal squamous cell carcinoma

Objective: The mainstay treatment of esophageal squamous cell carcinoma(ESCC) involves chemotherapy and immunotherapy. However, alternative therapies are required for patients who are refractory or intolerant to existing therapies.Methods: In this single-arm, multicenter, open-label phase Ib study, 30 patients received an intravenous infusion of SCT200, an antiepidermal growth factor receptor(EGFR) monoclonal antibody, 6.0 mg/kg once a week for 6 weeks, followed by 8.0 mg/kg once every 2 weeks u...     

中性粒细胞异常增殖相关的BCR/ABL-慢性白血病的临床特征

目的:探讨与中性粒细胞异常增殖相关的BCR/ABL-慢性白血病的临床特征.方法:报告3例不同类型与中性粒细胞异常增殖相关的BCR/ABL-慢性白血病并结合文献进行讨论.结果:3例均为老年男性,表现为以中性粒细胞为主的白细胞异常增多、BCR/ABL融合基因阴性.例1诊断为慢性中性粒细胞白血病(CNL),脾大,外周血以成熟中性粒细胞增高为特征,胞浆内中毒颗粒易见,无明显病态造血,中性粒细胞碱性磷酸酶(NAP)染色强阳性,骨髓粒系增生明显活跃.例2诊断为不典型慢性髓细胞白血病(aCML),血涂片示不成熟粒细胞比例增高伴粒系病态造血,尤其核染色质异常浓聚更为明显,骨髓象表现为髓系增生和病态造血,原始细胞轻度增多.例3诊断为慢性粒单核细胞白血病(CMML),外周血成熟单核细胞数量和比例异常偏高,粒系病态如核分叶过多、环状核和假性Pelger-Huet畸形等易见,骨髓髓系增生明显活跃伴病态造血,无原始细胞增多.结论:中性粒细胞异常增殖相关的BCR/ABL-慢性白血病较为少见,易于误诊,细胞形态学特征是诊断BCR/ABL-慢性白血病的基础.临床表现、多种实验室检查结果尤其是分子生物学等有助于正确诊断这类疾病.     

Angiogenesis in implantation

Problem Implantation failure and early pregnancy loss are common following natural conceptions and they are particularly important clinical hurdles to overcome following assisted reproduction attempts. The importance of adequate vascular development and maintenance during implantation has recently become a major focus of investigation. Materials and methods Review of current published literature was undertaken to summerize the cells and cell products that regulate tissue vascularity during implantation. Results Vascular development at the maternal fetal interface can be regulated by a number of different cell types; two principal candidates are trophoblast and natural killer cells. A wide range of soluble factors, some with well established angiogenic functions as well as other more novel factors, can contribute to vascular development and maintenance at the maternal–fetal interface. Conclusions Robust vascular development occurs during implantation and early placentation of normal pregnancies. Studies to define the extent and mechanisms by which defects in vascularity contribute to human implantation failure and early miscarriage need to be undertaken. Vascular development during implantation is mediated by numerous cell types and cell products and aberrant vascularity likely contributes to implantation failure and early pregnancy loss.     

首发精神分裂症患者IL-1β的血清蛋白水平及PBMC mRNA表达

目的从基因转录和蛋白水平,观察精神分裂症中IL-1β的动态变化情况,了解其免疫状态,并探讨IL-1β与精神病理的关系。方法采用病例对照研究方法,精神分裂症组为根据DSM—Ⅳ诊断为精神分裂症的本地汉族患者83例,单一应用利培酮治疗,在治疗前后评定PANSS量表;对照组为健康志愿者65例。应用ELISA和RT—PCR方法,同时检测血清IL-1β蛋白水平和PBMC中IL-1β mRNA表达。结果（1）精神分裂症组治疗前、后与对照组血清IL--1β水平相比,均明显增高,差异有显著性（P〈0．05）。精神分裂症组治疗后血清IL—-1β水平与治疗前相比明显下降,差异有显著性（P〈0．05）。（2）IL-1β治疗前后的差值与PANSS量表降分率呈显著正相关（r=0．388,P〈0．05）。（3）精神分裂症组治疗前、后PBMC中IL-1β mRNA表达与对照组相比明显增高,差异有显著性（P〈0．05）。精神分裂症组治疗后PBMC中IL-1β mRNA表达与治疗前相比明显下降,差异有显著性（P〈0．05）。结论（1）精神分裂症患者存在免疫激活,IL-1β水平的变化可作为病情缓解的一个灵敏指标。（2）精神分裂症患者PBMC呈激活状态,是IL-1β的主要来源之一,探讨影响PBMC细胞因子mRNA表达的因素,有助于反映对机体的免疫状况的影响。     

APC介入治疗支气管结核的临床疗效探讨

目的探讨氩等离子体凝固(argon plasma coagulation,APC)介入治疗支气管结核的临床疗效。方法对40例确诊支气管结核的患者实施经可弯曲电子支气管镜氩气刀介入治疗,并观察其疗效。结果40例治疗1～4次,平均1.9次,经支气管镜复查,显效30例,占75%;有效10例,占25%;总有效率100%。不良反应:治疗中22例有轻微刺激性呛咳,4例感觉局部烧灼痛,未发生支气管壁坏死、穿孔、气胸、纵隔气肿等并发症。结论APC介入治疗支气管结核,在解除支气管阻塞、加速病灶的吸收及组织再生和修复方面疗效确切,痰菌阴转率及肺不张治愈率均较高,能缓解支气管狭窄后遗症,安全性高,不良反应小,有较好的临床应用价值。     

三甲医院医保管理工作的难点及对策研究简

通过医院和参保人两个途径对相关人员进行医院医保管理工作的调研,指出三甲医院医保管理工作存在有事实依据取证和处罚难、实时有效的监督和控制难、规范化管理监管难、参保对象的期望值与实际差距较大等4个方面的难点,进而提出完善政策体系,优化宣传策略、建立医保“一站式”服务体系、联合其他定点医院共同协议管理、设立监督岗位,强化监管力度等建议。     

2006～2007年桐乡市不同人群HIV监测检测结果分析

目的:分析不同人群HIV监测结果及感染者特征,制定有效的防控措施。方法:采用EXECL数据库对2006~2007年桐乡市各艾滋病实验室检测数据和网络直报个案资料进行整理、分析。结果:2006年检测38674份血清,确认HIV抗体阳性为10例,占0.03%,2007年检测37287份,确认HIV抗体阳性为6例,占0.02%,HIV阳性者的家属的检测确认阳性率都最高,分别为14.29%和16.67%。感染者特征中21~25岁为感染主要年龄段,以无业为主,以性行为为HIV传播的高危行为,住在城镇较多。结论:桐乡市的艾滋病处于低流行水平,且以特定人群为主,有向一般人群扩散的趋势,故要继续加强监测并采取以开展健康教育为主的干预,特别是面向农村和农民,提高自我防范意识,以遏制艾滋病在我市的流行和蔓延。