全文获取类型
收费全文 | 8254篇 |
免费 | 845篇 |
国内免费 | 496篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 54篇 |
妇产科学 | 77篇 |
基础医学 | 1122篇 |
口腔科学 | 84篇 |
临床医学 | 1150篇 |
内科学 | 1585篇 |
皮肤病学 | 71篇 |
神经病学 | 441篇 |
特种医学 | 345篇 |
外国民族医学 | 15篇 |
外科学 | 863篇 |
综合类 | 929篇 |
现状与发展 | 4篇 |
预防医学 | 475篇 |
眼科学 | 71篇 |
药学 | 849篇 |
35篇 | |
中国医学 | 585篇 |
肿瘤学 | 803篇 |
出版年
2024年 | 27篇 |
2023年 | 176篇 |
2022年 | 476篇 |
2021年 | 643篇 |
2020年 | 488篇 |
2019年 | 425篇 |
2018年 | 421篇 |
2017年 | 362篇 |
2016年 | 394篇 |
2015年 | 575篇 |
2014年 | 665篇 |
2013年 | 632篇 |
2012年 | 764篇 |
2011年 | 798篇 |
2010年 | 511篇 |
2009年 | 413篇 |
2008年 | 391篇 |
2007年 | 370篇 |
2006年 | 309篇 |
2005年 | 332篇 |
2004年 | 66篇 |
2003年 | 60篇 |
2002年 | 30篇 |
2001年 | 16篇 |
2000年 | 11篇 |
1999年 | 11篇 |
1998年 | 18篇 |
1997年 | 22篇 |
1996年 | 24篇 |
1995年 | 22篇 |
1994年 | 18篇 |
1993年 | 12篇 |
1992年 | 4篇 |
1991年 | 2篇 |
1990年 | 14篇 |
1989年 | 19篇 |
1988年 | 14篇 |
1987年 | 12篇 |
1986年 | 3篇 |
1985年 | 4篇 |
1984年 | 2篇 |
1983年 | 5篇 |
1982年 | 9篇 |
1981年 | 5篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1976年 | 3篇 |
1975年 | 5篇 |
1959年 | 1篇 |
排序方式: 共有9595条查询结果,搜索用时 15 毫秒
91.
92.
目的:研究人参皂苷Rg1对原代培养正常大鼠大脑皮质神经细胞生物膜的影响。方法:采用细胞培养技术,运用比色法、硫代巴比妥酸法、黄嘌呤氧化酶法(羟胺法)和微量酶标法测定人参皂苷Rg1对细胞内ACP活力、MDA含量、SOD活力及LDH释放量的影响。结果:1mg/ml、2 mg/ml及4 mg/ml人参皂苷Rg1作用30min可不同程度增加正常培养神经细胞的LDH释放量和细胞内SOD活力,降低细胞内ACP活力及MDA含量。结论:1mg/ml、2 mg/ml及4 mg/ml人参皂苷Rg1作用30min对正常培养大脑皮质神经细胞生物膜具有显著影响,其中对溶酶体膜有保护作用,对生物膜的脂质过氧化反应有抑制作用,能减轻自由基对生物膜的攻击及损伤,但对细胞膜可能有一定的损伤作用。 相似文献
93.
Jun-ying Jia Er-huan Zang Li-juan Lv Qin-yu Li Chun-hua Zhang Ying Xia Lei Zhange Lian-sheng Dangf Min-hui Li e 《中草药(英文版)》2021,13(1):49-63
Ischemic heart diseases are one of the major causes of death worldwide. Effective restoration of blood flow can significantly improve patients’ quality of life and reduce mortality. However, reperfusion injury cannot be ignored. Flavonoids possess well-established antioxidant properties;They also have other benefits that may be relevant for ameliorating myocardial ischemia-reperfusion injury(MIRI). In this review,we focus on flavonoids with cardiovascular-protection function and emphasize their pharmacological effects. The main mechanisms of flavonoid pharmacological activities against MIRI involve the following aspects: a) antioxidant, b) anti-inflammatory, c) anti-platelet aggregation, d) anti-apoptosis, and e)myocardial-function regulation activities. We also summarized the effectiveness of flavonoids for MIRI. 相似文献
94.
目的:观察不同针刺刺激量对胆囊结石术后胃肠功能紊乱患者胃肠功能的恢复以及血管活性肠肽(VIP)的影响。方法:将32例患者分为四组,分为提插强刺激组、提插弱刺激组、捻转强刺激组、捻转弱刺激组,观察给予不同针刺刺激后四组患者的胃肠功能和血管活性肠肽(VIP)的变化。结果:统计学处理后,对于肠鸣音恢复时间,提插强刺激组和捻转弱刺激组之间的比较有统计学意义;对于术后排气时间,提插强刺激与捻转强刺激、捻转弱刺激之间,提插弱刺激与捻转弱刺激之间均有统计学意义(P<0.05),其余无统计学意义;术后排便时间统计结果无差异(P>0.05)。对于VIP,四组病人术前血管活性肠肽无差异(P>0.05),具有可比性;术后第2天四组病人血浆血管活性肠肽含量治疗后均有回升趋势,提插弱刺激组和捻转弱刺激组病人血浆VIP含量在治疗后与提插强刺激组和捻转强刺激组比较均有明显差异(P<0.05)。结论:强刺激对血管活性肠肽的变化的影响较弱刺激好,同样的刺激量下提插较捻转的对血管活性肠肽的变化影响大,提插强刺激对于胃肠功能恢复的作用由于其他三种。 相似文献
95.
Gui-Yuan Lv Yan-Ping Zhang Jian-Li Gao Jing-Jing Yu Jing Lei Zhi-Ru Zhang Bo Li Ruan-Juan Zhan Su-Hong Chen 《Journal of ethnopharmacology》2013
Ethnopharmacological relevance
Flos Chrysanthemi is used in a variety of diseases in traditional Chinese medicine including hypertension, and the total flavonoids (rich in luteolin (LUT) and buddleoside (BUD)) of Flos Chrysanthemi is known to modulate vascular functions and reduce the blood pressure. However, the active flavonoids and their synergistic effects on anti-hypertension are still unclear. To investigate the combined anti-hypertension effects of LUT and BUD enriched extracts on spontaneously hypertensive rats (SHR), as well as the anti-hypertensive mechanism of LUT&BUD mixture.Materials and methods
CODA Mouse & Rat Tail-Cuff Blood Pressure System was used to measure the systolic blood pressure (SBP) and diastolic blood pressure (DBP) of SHR after treated with extracts contains with LUT and/or BUD. The expressions of Ang II, PRA, ALD, ET, PGI2 and TXB2 were investigated by ELASA. Serum NO concentration was measured by the method of Nitric acid reductase.Results
A single administration of LUT, BUD, or LUT:BUD=1:1 significantly reduced SBP by about 3.35 mmHg, 4.39 mmHg and 15.42 mmHg, respectively. Chronic administration of LBM (at 60 mg/kg; p.o. for 30 days) reduced both SBP and DBP by 4.04% and 5.24% of the vehicle group, respectively. Oral administration of LBM at 60 mg/kg inhibited the serum levels of ANG, ALD and ET, but increased serum NO concentration.Conclusion
This study shows the synergistic anti-hypertension effects of LUT and BUD in SHR. The effects of LBM on blood pressure are associated with RAAS and endothelial system. Thus, our experiments suggest that the combination of luteolin and buddleoside from Flos Chrysanthemi are potentially useful for the therapeutic treatments for hypertension. 相似文献96.
目的采用高效液相色谱法测定红宝散中欧前胡素的含量。方法采用HPLC法,Apollo-C18(250mm×4.6mm,5μm)色谱柱,流动相为甲醇一水(55:45),流速为1.0mL·min-1,紫外检测波长为300nm,柱温为室温。结果欧前胡素进样量在0.0300-0.2000ug线性关系良好,r=0.9999,平均回收率99.68%,RSD=0.35%。结论本方法准确、简便、快速,可作为红宝散中欧前胡素的含量测定。 相似文献
97.
98.
目的 建立南葶苈子饮片中槲皮素、山奈酚及异鼠李素的含量测定方法。方法 采用Diamond—C18色谱柱;甲醇-0.4%磷酸溶液(50:50)为流动相;流速1.0mL·min;检测波长360nm。结果 线性范围:槲皮素0.1184~0.8288μg,r=0.9995,山奈酚0.0258~0.1806/μg,r=0.9994,异鼠李素0.0444~0.3108μg,r=0.9994;平均回收率:槲皮素99.51%,RSD=2.10%(n=6),山奈酚101.03%,RSD=2.08%(n=6),异鼠李素99.80%,RSD=2.09%(n=6)。结论 该法操作简便、准确,重复性好,可用于南葶苈子饮片中槲皮素、山奈酚及异鼠李素的含量测定。 相似文献
99.
Jiabin Cai Lili Zheng Danni Lv Min He Jieni Xiong Junqing Mao 《Pediatric hematology and oncology》2020,37(7):620-629
AbstractSince the emergence of patients with COVID-19 in December 2019, the virus has rapidly spread worldwide. Children with malignant tumors are more prone to be infected and develop severe infections. Prevention and control of the pandemic and ensuring the progress of the cancer diagnosis and treatment is a significant problem in the current scenario. This article proposes a scientific management system for patients with solid tumors to guarantee emergency surgery, rationally arrange limited-term surgery, appropriately defer elective surgery, and guarantee regular chemotherapy, while protecting children from SARS-CoV-2 infection and ensuring the continuity of comprehensive diagnosis and treatment. 相似文献
100.