P波离散度对急性心肌梗死并发房颤的意义

目的　探讨P波离散度 (Pd)对急性心肌梗死并发房颤的预测价值。 方法　 选 36例急性心肌梗死并发房颤的患者 ,观察其P波离散度 ,P波最大时限 (Pmax)。选 80例单纯急性心肌梗死的患者 ,作对照分析。 结果　急性心肌梗死并发房颤的Pd、Pmax与对照组比较有明显差异 (P <0 .0 1)。 结论　P波离散度可作为急性心肌梗死患者并发房颤的一预测指标。     

试论乌梅丸以气味配伍组方

乌梅丸出自《伤寒论》厥阴病篇，其为历代医家推崇的关键在于紧扣病机，方证对应，组方合理，配伍精当。本文从酸辛苦甘，刚柔相济；清上温下，攻补兼施；辛开苦降，土木两调3个方面讨论了乌梅丸按照气味配伍组方的特点。     

甘草饮片超微粉碎前后甘草酸溶出行为的比较研究

目的 :考察超微粉碎前后甘草饮片中甘草酸溶出行为变化规律。方法 :以甘草酸含量为测定指标 ,分别对不同的样品进行测定实验。结果 :超微粉碎后甘草酸的溶出显著提高 ,且粉碎时间越长 ,粒度越细 ,甘草酸溶出越易。结论 :超微粉碎后有助于甘草饮片中甘草酸的溶出 ,粉碎粒度对甘草酸的溶出有显著的影响。     

我国天然活性多糖药理研究进展

近年来，多糖的研究日益受到重视。天然多糖具有丰富多彩的药理活性，本文主要综述了多糖在抗肿瘤、免疫调节、抗衰老、抗血糖、抗病毒、降血脂等方面发挥着重要的活性作用。     

中药活性成分治疗类风湿性关节炎的研究

类风湿性关节炎是一种全身性、自身免疫性疾病，是临床难治疾病之一。中药对类风湿性关节炎的治疗疗效确切、安全、副作用少，优势独特，具有广泛的应用前景和重要的开发价值。而中药抗类风湿性关节炎的活性成分种类繁多，生物活性表现在抗菌、抗炎、镇痛和免疫调节等多方面。本文系统地综述了中药抗类风湿性关节炎活性成分的研究现状。     

电针治疗对老年性痴呆大鼠血清β淀粉样蛋白及生长因子水平的影响

目的:观察电针对老年性痴呆(AD)模型大鼠β-淀粉样蛋白及转化生长因子(TGF-α)的影响,揭示针灸治疗的作用机理和针灸治疗AD的免疫基础。方法:建立AD大鼠模型,随机分为电针组、喜得镇组、模型自然恢复组、假手术组,观察血清β-AP和TGF-α水平。结果:电针组和喜得镇组大鼠血清β-AP水平明显下降(P<0.05),但仍明显高于假手术组。结论:电针能降低AD模型大鼠血清中β淀粉样蛋白及TGF-α。     

谷胱甘肽治疗帕金森病30例临床观察

目的 探讨还原型谷胱甘肽(古拉定，GLT)对帕金森病人治疗效果，观察GLT治疗后病人血超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH—Px)、丙二醛(MDA)水平的变化。方法 选择30例临床未治疗或服用美多巴因副反应被迫减药病人，应用GLT进行治疗，治疗前后行血SOD、GSH—PX、MDA测定，并设立对照组、正常人组比较；治疗、Px对照组进行了治疗前后H—Y分级及Webster评分。结果 治疗组和正常人组比较，血SOD、GSH—Px显减低(P＜o．01)，MDA显增高(P＜o．01)；GLT治疗后，SOD、GSH—Px值较治疗前明显升高(P＜o．05、P＜o．01)，MDA值下降(P＜o．05)，而对照组改变不明显。治疗前后评分，治疗后临床症状有显改善(P＜o．01)，与对照组比较，两组有显差异(P＜o．01)。结论 GLT对PD病人有较显治疗作用。     

加替沙星片治疗急性细菌性感染随机双盲对照研究

目的：评价加替沙星治疗急性细菌性感染的安全性和有效性。方法：采用多中心、随机双盲、阳性药平行对照方法，对临床确诊为轻、中度急性呼吸系统或泌尿系统感染的患者220例，试验组、时照组各110例，分别口服加替沙星、氧氟沙星200mg，bid，疗程7～14d。结果：试验组103例、对照组100例完成试验。试验组和对照组痊愈率分剐为76．7％和71．0％，有效率分别为93．2％和85．0％，细菌清除率分别为96．7％和93．8％，两组间差异均无统计学意义。不良反应发生率分别为16．4％和18．2％。试验组和对照组分别有5例(4．55％)和9例（8．18％)出现ALT、AST轻度升高，停药10d后复查恢复正常。结论：加替沙星抗菌谱广，抗菌活性强，能安全有效地治疗轻、中度急性呼吸系统和泌尿系统感染。     

应用胰岛素泵治疗儿童及青少年1型糖尿病对糖代谢的影响

为观察应用胰岛素泵治疗儿童及青少年1型糖尿病(T1DM)对糖代谢的影响 ,随访10例胰岛素泵治疗的T1DM患儿 ,分别观察胰岛素泵治疗前、后6个月的糖化血红蛋白值(HbA1c)、胰岛素用量、严重低血糖及酮症酸中毒发生次数的变化情况。结果显示 ,胰岛素泵治疗6个月后HbA1c 显著下降 ,治疗前为8.97 %±1.69 %,治疗后为7.51 %±1.17 % (t=2.52 ,P<0.05) ;胰岛素用量无显著下降 ;未发生严重低血糖和酮症酸中毒。表明胰岛素泵治疗可有效控制血糖 ,明显降低HbA1c,减少低血糖及酮症酸中毒的发生 ,是儿童及青少年T1DM常规治疗的较好选择。     

Basic fibroblast growth factor protects auditory neurons and hair cells from noise exposure and glutamate neurotoxicity

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