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排序方式: 共有9996条查询结果,搜索用时 15 毫秒
991.
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Ashley Rajappan BSc Anna Pearce PhD Hazel M. Inskip PhD Janis Baird PhD Sarah R. Crozier PhD Cyrus Cooper FMedSci Keith M. Godfrey FRCP Graham Roberts MRCPCH DM Jane S.A. Lucas FRCPCH PhD Katharine C. Pike FRCPCH PhD The Southampton Women's Survey Study Group 《Pediatric pulmonology》2017,52(10):1291-1299
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Jon B. Toledo Matthias Arnold Gabi Kastenmüller Rui Chang Rebecca A. Baillie Xianlin Han Madhav Thambisetty Jessica D. Tenenbaum Karsten Suhre J. Will Thompson Lisa St. John-Williams Siamak MahmoudianDehkordi Daniel M. Rotroff John R. Jack Alison Motsinger-Reif Shannon L. Risacher Colette Blach Joseph E. Lucas Rima Kaddurah-Daouk 《Alzheimer's & dementia》2017,13(9):965-984
Introduction
The Alzheimer's Disease Research Summits of 2012 and 2015 incorporated experts from academia, industry, and nonprofit organizations to develop new research directions to transform our understanding of Alzheimer's disease (AD) and propel the development of critically needed therapies. In response to their recommendations, big data at multiple levels are being generated and integrated to study network failures in disease. We used metabolomics as a global biochemical approach to identify peripheral metabolic changes in AD patients and correlate them to cerebrospinal fluid pathology markers, imaging features, and cognitive performance.Methods
Fasting serum samples from the Alzheimer's Disease Neuroimaging Initiative (199 control, 356 mild cognitive impairment, and 175 AD participants) were analyzed using the AbsoluteIDQ-p180 kit. Performance was validated in blinded replicates, and values were medication adjusted.Results
Multivariable-adjusted analyses showed that sphingomyelins and ether-containing phosphatidylcholines were altered in preclinical biomarker-defined AD stages, whereas acylcarnitines and several amines, including the branched-chain amino acid valine and α-aminoadipic acid, changed in symptomatic stages. Several of the analytes showed consistent associations in the Rotterdam, Erasmus Rucphen Family, and Indiana Memory and Aging Studies. Partial correlation networks constructed for Aβ1–42, tau, imaging, and cognitive changes provided initial biochemical insights for disease-related processes. Coexpression networks interconnected key metabolic effectors of disease.Discussion
Metabolomics identified key disease-related metabolic changes and disease-progression-related changes. Defining metabolic changes during AD disease trajectory and its relationship to clinical phenotypes provides a powerful roadmap for drug and biomarker discovery. 相似文献994.
Maitrot A Lucas MF Doncarli C Farina D 《Medical & biological engineering & computing》2005,43(4):487-492
In the study, an efficient method to perform supervised classification of surface electromyogram (EMG) signals is proposed.
The method is based on the choice of a relevant representation space and its optimisation with respect to a training set.
As EMG signals are the summation of compact-support waveforms (the motor unit action potentials), a natural tool for their
representation is the discrete dyadic wavelet transform. The feature space was thus built from the marginals of a discrete
wavelet decomposition. The mother wavelet was designed to minimise the probability of classification error estimated on the
learning set (supervised classification). As a representative example, the method was applied to simulate surface EMG signals
generated by motor units with different degrees of short-term synchronisation. The proposed approach was able to distinguish
surface EMG signals with degrees of synchronisation that differed by 10%, with a misclassification rate of 8%. The performance
of a spectral-based classification (error rate approximately 33%) and of the classification with Daubechies wavelet (21%)
was significantly poorer than with the proposed wavelet optimisation. The method can be used for a number of different application
fields of surface EMG classification, as the feature space is adapted to the characteristics of the signal that discriminate
between classes.
An erratum to this article is available at . 相似文献
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A multicenter validation of recombinant β3 integrin–coupled beads to detect human platelet antigen‐1 alloantibodies in 498 cases of fetomaternal alloimmune thrombocytopenia 下载免费PDF全文
Winnie Chong Ernest Turro Paul Metcalfe Rizwan Yusuf Yves Mérieux Dominique Rigal Leendert Porcelijn Elly Huiskes Geoff Lucas Nina Bendukidze Ann Green Rita Fontão‐Wendel Anne Husebekk Jonathan Dixey Alan Guest Rosey Mushens Willem H. Ouwehand Cristina V. Navarrete 《Transfusion》2015,55(11):2742-2751
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Resin composite plus connective tissue graft to treat single maxillary gingival recession associated with non‐carious cervical lesion: randomized clinical trial 下载免费PDF全文
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Saulo Gabriel Moreira Falci Lucas Duarte‐Rodrigues Ednele Fabyene Primo‐Miranda Patrícia Furtado Gonalves Endi Lanza Galvo 《Special care in dentistry》2019,39(4):362-374
A systematic literature search was conducted (through April 2017), using Web of Science, PubMed and Virtual Health Library, manual reference list, and grey literature searches. The quality of the studies was evaluated using the Newcastle‐Ottawa Quality Assessment Scale. The meta‐analysis was performed using R software. A total of 30 studies was included in this review. From a total of 25 studies included in the meta‐analysis, the prevalence of oral and maxillofacial injuries among epileptic subjects was 19%. Among the epileptic patients who suffered some type of injury due to epileptic seizures, 52% had facial soft tissue injuries (95%CI: 28‐75%), 18% suffered dental trauma (95%CI: 11‐29%), and 12% (95%CI: 4‐28%) suffered maxillofacial fractures. Epileptic patients were more likely to have oral and maxillofacial injuries than healthy individuals (OR: 5.22, 95%CI: 2.84‐9.36) and subjects with psychogenic nonepileptic seizures (OR: 2.77, 95%CI: 1.28‐5.99), but not than patients with special needs (OR: 2.45,95%CI: 0.95‐6.31). 相似文献
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