全文获取类型
收费全文 | 616篇 |
免费 | 53篇 |
国内免费 | 14篇 |
专业分类
儿科学 | 12篇 |
妇产科学 | 9篇 |
基础医学 | 84篇 |
口腔科学 | 7篇 |
临床医学 | 54篇 |
内科学 | 106篇 |
皮肤病学 | 9篇 |
神经病学 | 53篇 |
特种医学 | 98篇 |
外科学 | 64篇 |
综合类 | 11篇 |
预防医学 | 42篇 |
眼科学 | 8篇 |
药学 | 37篇 |
中国医学 | 3篇 |
肿瘤学 | 86篇 |
出版年
2023年 | 3篇 |
2022年 | 13篇 |
2021年 | 19篇 |
2020年 | 11篇 |
2019年 | 13篇 |
2018年 | 22篇 |
2017年 | 21篇 |
2016年 | 27篇 |
2015年 | 16篇 |
2014年 | 26篇 |
2013年 | 30篇 |
2012年 | 21篇 |
2011年 | 37篇 |
2010年 | 19篇 |
2009年 | 13篇 |
2008年 | 28篇 |
2007年 | 35篇 |
2006年 | 28篇 |
2005年 | 20篇 |
2004年 | 19篇 |
2003年 | 10篇 |
2002年 | 20篇 |
2001年 | 15篇 |
2000年 | 11篇 |
1999年 | 13篇 |
1998年 | 26篇 |
1997年 | 16篇 |
1996年 | 15篇 |
1995年 | 15篇 |
1994年 | 8篇 |
1993年 | 13篇 |
1992年 | 1篇 |
1991年 | 9篇 |
1990年 | 10篇 |
1989年 | 7篇 |
1988年 | 14篇 |
1987年 | 8篇 |
1986年 | 1篇 |
1985年 | 10篇 |
1984年 | 6篇 |
1983年 | 9篇 |
1982年 | 7篇 |
1981年 | 4篇 |
1980年 | 4篇 |
1979年 | 2篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1971年 | 1篇 |
1959年 | 1篇 |
排序方式: 共有683条查询结果,搜索用时 15 毫秒
101.
Three patients who had complete agenesis and two patients who had partial agenesis of the corpus callosum (ACC) underwent magnetic resonance (MR) imaging. In addition to excellent visualization of the indirect signs of ACC, direct vivid display (short T1) of the corpus callosum on sagittal images allowed better evaluation of subtle abnormalities than has been possible with other modalities. Associated abnormalities were also well-displayed. MR is the initial procedure of choice in evaluation of the corpus callosum. 相似文献
102.
A case of bronchial asthma and dermatitis due to spiramycin is described in a non-atopic woman who worked as a chick breeder and handling poultry feed containing antibiotic or chemoterapic drugs including spiramycin, chlortetracycline and sulfadimethoxine. Patch tests showed a vigorous delayed reaction to spiramycin. Inhalation challenge test with the chick feed containing spiramycin reproduced symptoms of late asthmatic response (FEV1 fell by 14% and FEF25-75 by 25% within the 4th and 6th hour) with leucocytosis. No significant modification of FEV1 and FEF25-75 was observed within 24 hours after challenge with chick feeds containing other antibiotic or chemotherapeutic agents but not spiramycin. On leaving her job, the patient had no further skin reactions or bronchial asthma episodes. This case suggests that allergic reactions to a chemical product may involve both type III and IV hypersensitivity. 相似文献
103.
Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis 总被引:1,自引:0,他引:1
104.
105.
Sances G Ghiotto N Loi M Guaschino E Marchioni E Catarci T Nappi G 《The journal of headache and pain》2005,6(4):307-309
Medication–overuse
headache (MOH) is one of the
headache forms that most frequently
prompts patients to consult a
specialist headache centre. The prevaence
of this form in the general
population is approximately 1–2%.
Around 40% of patients seen at
headache centres present with a
chronic form of headache and 80%
of this chronic headache patients
make excessive use of symptomatic
drugs. MOH shows a clinical
improvement, accompained by a
reduction in the consumption of
analgesic drugs, if patients are submitted
to detoxification therapy.
But detoxification is only the first
stage in a long and complex course
of care and global approach
demands adequate follow–up visit
to prevent early relapses. At the
Headache Centre of the C. Mondino
Institute of Neurologt in Pavia, a
course of care (CARE) has been
developed for the complente management
of patients with MOH both
during Hospitalization and durimg
the subsequent follow–up period.
CARE IS designed to trace the clinical,
psychopathological and pharmacological
profile of MOH in the
short–, medium– and long–term; to
look for factors possibility predictive
of relapse; to assess the direct
costs linked to overuse–headache in
the year leading up to and following
detoxification; and to evaluate
disability, in terms of working days
lost, before and after detoxification. 相似文献
106.
Tarantino G Spanò A Loi G Parisi A Tarantino M Brancaccio G Gaeta GB Riccio A 《World journal of gastroenterology : WJG》2011,17(12):1606-1613
AIM:To investigate the spleen vascular involvement and the presence of liver fibrosis in a population of subjects with established systemic sclerosis(SSc).METHODS:In a cross-sectional fashion,17 patients with SSc were compared with 18 patients suffering from hepatitis C virus(HCV) -related liver cirrhosis,grade A and B Child-Pugh classification.Eighteen non elderly subjects,apparently healthy,were used as the control group.Splenic artery resistivity index(SARI) at doppler ultraSound,transient elastography o... 相似文献
107.
Michael G. Zywiel Loi��y H. Mustafa Peter M. Bonutti Michael A. Mont 《International orthopaedics》2011,35(6):797-802
Dislocation is one of the most common complications of total hip arthroplasty. The use of constrained liners is an option for the management of chronic hip instability, typically used after other methods have failed. The purposes of this study were to evaluate the overall clinical outcomes and failure rates of a tripolar constrained liner design, to assess the radiographic outcomes of its use, and to examine whether various factors such as abductor mechanism quality and history of previous revision surgeries were associated with an increased risk of failure. Forty-three hips in 39 patients who had a mean follow-up of 51 months (range, 24–110 months) were reviewed. Ninety-one percent of the hips (39 of 43 hips) did not need any revisions over the study period. A new liner was implanted in all four failed hips with concurrent revision of the acetabular cup in three cases. No further dislocations occurred in this group. The mean hip score for surviving hips was 82 points (range, 38–100 points) at final follow-up. Radiographic evaluation revealed stable, well-fixed acetabular components in all surviving hips without progressive radiolucencies. No association was found between abductor muscle quality and the incidence of failure, but patients who experienced a constrained liner failure were more likely to have undergone at least one previous hip revision operation. Tripolar constrained acetabular liners can provide successful outcomes in patients with hip instability, although it is important not to rely on the use of a constrained liner alone in an attempt to compensate for other correctable factors such as component positioning. 相似文献
108.
109.
110.
Dahlke MH Loi R Warren A Holz L Popp FC Weiss DJ Piso P Bowen DG McCaughan GW Schlitt HJ Bertolino P 《Journal of hepatology》2006,44(2):334-341
BACKGROUND/AIMS: The role of adult bone marrow-derived cells (BMC) in hepatic regeneration is controversial. Both transdifferentiation of BMC as well as fusion with hepatocytes have been suggested in toxin-based and genetic selection models. METHODS: We have developed a transgenic mouse model of immune-mediated hepatitis to clarify the role of BMC in liver regeneration following injury mediated by T cells. RESULTS: Repeated adoptive transfer of transgenic T cells into bone marrow chimeras resulted in multiple waves of hepatitis. Hepatocytes derived from donor bone marrow were identified using a self-protein that does not interfere with hepatocyte function and proliferation in recipient animals. Some cells contained one recipient nucleus and another independent donor bone marrow-derived nucleus, suggesting that cellular fusion plays some role in liver repair after immune hepatitis. However, despite pronounced infiltration by myeloid cells, the frequency of fusion was extremely low. CONCLUSIONS: This study provides a unique, clinically relevant model in which fusion hepatocytes can be purified and characterized by the expression of donor MHC antigen. It demonstrates that although fusion between BMC and hepatocytes occurs under conditions of inflammation that correspond to human disease, its frequency needs to be increased to be of any therapeutic value. 相似文献