全文获取类型
收费全文 | 331473篇 |
免费 | 27346篇 |
国内免费 | 16613篇 |
专业分类
耳鼻咽喉 | 3420篇 |
儿科学 | 5108篇 |
妇产科学 | 7000篇 |
基础医学 | 44050篇 |
口腔科学 | 7120篇 |
临床医学 | 39531篇 |
内科学 | 52976篇 |
皮肤病学 | 4566篇 |
神经病学 | 20013篇 |
特种医学 | 12078篇 |
外国民族医学 | 141篇 |
外科学 | 37614篇 |
综合类 | 39834篇 |
现状与发展 | 55篇 |
一般理论 | 53篇 |
预防医学 | 21311篇 |
眼科学 | 9397篇 |
药学 | 32374篇 |
192篇 | |
中国医学 | 13065篇 |
肿瘤学 | 25534篇 |
出版年
2023年 | 3402篇 |
2022年 | 8270篇 |
2021年 | 12368篇 |
2020年 | 9042篇 |
2019年 | 8483篇 |
2018年 | 9491篇 |
2017年 | 8113篇 |
2016年 | 7734篇 |
2015年 | 11560篇 |
2014年 | 14243篇 |
2013年 | 12989篇 |
2012年 | 19344篇 |
2011年 | 21541篇 |
2010年 | 12663篇 |
2009年 | 10114篇 |
2008年 | 14305篇 |
2007年 | 14528篇 |
2006年 | 14666篇 |
2005年 | 14366篇 |
2004年 | 9881篇 |
2003年 | 9311篇 |
2002年 | 8052篇 |
2001年 | 11292篇 |
2000年 | 11913篇 |
1999年 | 11078篇 |
1998年 | 5172篇 |
1997年 | 4754篇 |
1996年 | 3708篇 |
1995年 | 3440篇 |
1994年 | 2915篇 |
1993年 | 2121篇 |
1992年 | 5485篇 |
1991年 | 5277篇 |
1990年 | 4709篇 |
1989年 | 4512篇 |
1988年 | 4314篇 |
1987年 | 3994篇 |
1986年 | 3690篇 |
1985年 | 3405篇 |
1984年 | 2318篇 |
1983年 | 1996篇 |
1979年 | 2030篇 |
1978年 | 1233篇 |
1975年 | 1245篇 |
1974年 | 1414篇 |
1973年 | 1459篇 |
1972年 | 1403篇 |
1971年 | 1276篇 |
1970年 | 1159篇 |
1969年 | 1146篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
121.
122.
123.
Marlen Z. Gonzalez Lane Beckes Joanna Chango Joseph P. Allen James A. Coan 《Social cognitive and affective neuroscience》2015,10(7):921-928
Neuroimaging studies using the social-exclusion paradigm Cyberball indicate increased dorsal anterior cingulate cortex (dACC) and right insula activity as a function of exclusion. However, comparatively less work has been done on how social status factors may moderate this finding. This study used the Cyberball paradigm with 85 (45 females) socio-economically diverse participants from a larger longitudinal sample. We tested whether neighborhood quality during adolescence would predict subsequent neural responding to social exclusion in young adulthood. Given previous behavioral studies indicating greater social vigilance and negative evaluation as a function of lower status, we expected that lower adolescent neighborhood quality would predict greater dACC activity during exclusion at young adulthood. Our findings indicate that young adults who lived in low-quality neighborhoods in adolescence showed greater dACC activity to social exclusion than those who lived in higher quality neighborhoods. Lower neighborhood quality also predicted greater prefrontal activation in the superior frontal gyrus, dorsal medial prefrontal cortex and the middle frontal gyrus, possibly indicating greater regulatory effort. Finally, this effect was not driven by subsequent ratings of distress during exclusion. In sum, adolescent neighborhood quality appears to potentiate neural responses to social exclusion in young adulthood, effects that are independent of felt distress. 相似文献
124.
125.
Feng He Yuanjun Ma Shi Li Haozhe Ren Qian Liu Xiaohua Chen Hui Miao Tao Ye Qian Lu Zuge Yang Tianle Li Xin Tong Hongxu Yang Mian Zhang Helin Wang Yazhou Wang Shibin Yu 《Journal of bone and mineral research》2022,37(5):1044-1055
Temporomandibular joint osteoarthritis (TMJOA) is a chronic degenerative disease for which the underlying mechanism still remains unclear. Compared with apoptosis and autophagy, necroptosis causes greater harm to tissue homeostasis by releasing damage-associated molecular patterns (DAMPs). However, the role of necroptosis and downstream key DAMPs in TMJOA is unknown. Here, rodent models of TMJOA were established by the unilateral anterior crossbite (UAC). Transmission electron microscopy (TEM) and immunohistochemistry of receptor interacting protein kinase 3 (RIPK3)/phosphorylation of mixed lineage kinase domain-like protein (pMLKL) were conducted to evaluate the occurrence of necroptosis in vivo. The therapeutic effects of blocking necroptosis were achieved by intra-articularly injecting RIPK3 or MLKL inhibitors and using RIPK3 or MLKL knockout mice. In vitro necroptosis of condylar chondrocyte was induced by combination of tumor necrosis factor alpha (TNFα), second mitochondria-derived activator of caspases (SMAC) mimetics and carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]- fluoromethylketone (z-VAD-fmk). The possible DAMPs released by necroptotic chondrocytes were screened by quantitative proteomics and blocked by specific antibody. Translucent cytosol, swollen organelles, and ruptured cell membranes, features of necroptosis, were frequently manifested in chondrocytes at the early stage of condylar cartilage degeneration in TMJOA, which was accompanied by upregulation of RIPK3/pMLKL. Inhibiting or knocking out RIPK3/MLKL significantly prevented cartilage degeneration. DAMPs released by necroptotic condylar chondrocytes, such as syndecan 4 (SDC4) and heat shock protein 90 (HSP90), were verified. Furthermore, blocking the function of SDC4 significantly attenuated the expression of TNFα in cartilage and synovium, and accordingly increased cartilage thickness and reduced synovial inflammation. Thus, the necroptotic vicious cycle of TNFα-SDC4-TNFα contributes to cartilage degeneration and synovitis, and can serve as a potential therapeutic target for treating TMJOA. © 2022 American Society for Bone and Mineral Research (ASBMR). 相似文献
126.
Jing Yang Changqing Liu Linxia Zhang Yanhui Liu Aihua Guo Huiwu Shi Xiaoxia Liu Ying Cheng 《Inflammation》2015,38(4):1415-1423
127.
128.
129.
130.