卫生资源配置不平衡之殇

在我国卫生资源总体不足和配置不合理。一方面,中国有13亿人口,占世界总人口的22%,而卫生总费用仅占世界卫生总费用的2%。更严重的是另一方面,据卫生部提供的数据,目前全国80%的医疗资源集中在大城市,其中的30%又集中在大医院。每年到大医院就诊的人群,有80%左右是在基层医院即可解决的常见病、多发病。     

听力测试中短文听写的应试技巧

复合式听写比听力选择题更强调语言综合运用能力。全面打好语言基本功是提高听写能力的重要途径。但听写训练具有自身的科学性和技巧性，多练加巧练可以取得事半功倍的成效。     

王焕禄老中医治疗哮喘发作期的用药经验

王焕禄老中医在长期的临床实践中，总结出治疗哮喘病的一些用药体会，兹介绍如下，以飨读者。     

卵巢肿瘤合并副肿瘤性综合征

卵巢肿瘤合并副肿瘤性综合征（ovarian tumor associated with paraneoplastic syndrome）并非罕见,但由于此综合征往往先于肿瘤出现,而因肿瘤病灶小或隐匿不易被发现,常被临床医师所忽略,导致肿瘤未能得到及时诊断和治疗.＂paraneoplastic syndrome＂一词有译为副肿瘤性综合征、副肿瘤综合征、副癌综合征、肿瘤外综合征者.此综合征为肿瘤患者的一种复合症状,该症状不能用肿瘤本身或肿瘤转移来解释.现按主要受累系统的几种综合征简介如下,以加强临床医师对卵巢肿瘤合并副肿瘤性综合征特点的认识,减少误诊、误治。     

Effects of cerulenin on the endogenous fatty acid synthetic activity in squamous cell carcinoma of the oral cavity.

PURPOSES: Inhibition of cerulenin on the endogenous fatty acid synthetic activities of oral squamous cell carcinoma (OSCC) and normal oral mucosa was assayed. METHODS: Squamous cell carcinoma and normal oral mucosa were collected fresh from surgical specimens. The collected tissues were minced in RPMI 1640 and divided into 3 groups: cerulenin treated, dimethylsulfoxide treated, and control. The tissues were incubated in [1(2)-(14)C]acetic acid, sodium salt for the last 2.5 hours of the treatment at 37 degrees C in 5% CO(2). After labeling, total lipids were extracted and counted for (14)C by scintillation counting. RESULTS: Endogenous fatty acid synthetic activities of oral squamous cell caranoma in the cerulenin-treated group decreased by 19% at 1 hour, 64% at 2 hours, and 87% at 4 hours; remained nearly unchanged in the dimethylsulfoxide-treated group; and increased slightly in the control group. The oral mucosa tissues were only mildly affected by cerulenin in fatty acid synthesis. CONCLUSIONS: Cerulenin significantly inhibits fatty acid synthetic activity in squamous cell carcinoma and only mildly affected the oral mucosa, indicating that the fatty acid synthetic pathway may be exploited as a target for developing anticancer drugs.