“全国肠道蠕虫病防治讲习班”在浙江省医学科学院召开

根据卫生部／世界卫生组织2004／2005年度卫生技术合作项目(CHN／MVP／1．2／001／02．01．02．LC．01)的计划安排，“全国肠道蠕虫病防治讲习班”于2004年11月9-13日在杭州市浙江省医学科学院举办。讲习班得到了卫生部、浙江省卫生厅、浙江省预防医学会和全国有关省(自治区)的支持。     

Safety, tolerability and pharmacokinetic study of recombinant human parathyroid hormone in healthy male Chinese subjects

AIM： To determine the safety, tolerability and pharmacokinetic parameters of a new drug recombinant human parathyroid hormone [ rhPTH （1-84）] in healthy male Chinese subjects. METHODS： domly divided Thirty-six healthy male volunteers were rangroups received into 3 groups. The volunteers in these single subcutaneous injection of rhPTH （ 1-84） in a dosage of 1, 2 and 4 μg/kg respectively. Blood samples were obtained before and after administration within 24 hours. The rhPTH concentrations in sennn were determined by enzyme linked immunosorbent assay （ELISA）. The pharmacokinetic parameters determined with use of standard noncompartmental analysis were the maximum serum concentration （ Cmax ）, the time to attain that concentration （ tmax ）, and the area under the serum concentration-time curve up to 24 hours（ AUC0-24 ） and up to infinity （AUC0-∞）. Dose proportionality of pharmacokinetic parameters （AUC, Cmax of every volunteer of each dosage and A UC was computed from log transformed data） and was examined by mean of analysis of variance （ANOVA） using SPSS software package. In the study, subjects＇ symptoms, objective signs, and vital signs, including blood pressure, heart rate, respiratory rate and body temperature, were checked and 12-lead electrocardiography was recorded before and after drug administration within 24 hours. Routine laboratory tests, including hematology, blood biochemistry, serum electrolyte, and urinalysis, were performed before and after drug administration within at 24 hours.[第一段]     

一项甘露醇治疗脑出血的随机对照研究

目的:研究甘露醇对自发性脑出血(ICH)患者的治疗效果。方法:将128例发病6d内经CT证实为幕上ICH的患者随机分为试验组和对照组。试验组患者接受20%甘露醇治疗,每4h给予100m l,共5d,在接下来的2d中逐渐减量并停用,对照组患者接受假输液。主要终点为1个月时的死亡率,次要终点为根据Barthel指数评分评定3个月时的功能残疾情况。结果:65例患者纳入试验组,63例患者纳入对照组。试验组和对照组患者在年龄、格拉斯哥昏迷量表(GCS)评分、加拿大神经功能量表(CNS)评分、瞳孔不对称、非偏瘫侧锥体束征、出血部位、中线移位和血肿向侧脑室扩展情况…     

芪附通便汤治疗老年功能性便秘219例

便秘是老年人常见的症状,分器质性和功能性。功能性便秘如果选药不当常常出现药物依赖性,久而久之便秘反而加重。作者自拟芪附通便汤配合大黄苏打片治疗老年功能性便秘219例,取得满意疗效,与单纯使用大黄苏打片或单纯使用芪附通便汤比较存在疗效好,依赖性小的特点。现介绍如下:     

老年颤证治疗四法

<正> 颤证又称颤振、振掉、震颤、肝风、身震摇,是以头部或肢体摇动、颤抖为主要临床表现的一种病证,类似现代医学的震颤麻痹(帕金森氏病),是发生于中年以上的中枢神经系统变性疾病。大多以50～60岁发病,且男性多于女性。根据前人的经验和自己的临床体会,立标本兼治、扶正祛邪为其治疗大纲,初步总结出颤证证治四法。     

EXPRESSION OF C-MYC AND N-RAS ONCOGENES IN HUMANHEPATOCELLULAR CARCINOMA AND PANCREATIC ADENOCARCINOMA A BIOCHEMICAL ANDIMMUNOCYTOCHEMICAL STUDY

WiLh RNA-DNA dot blot technique, the expression of c-myc and N-ras oncogenes in human hepato cellular carcinoma was found to be higher than in tie non-cancerous liver tissue adjacent to the carci noma (p<0.01). The expression of both oncogenes was high in the fetal liver and gradually decreased with age during development, indicating a probable co-operation of c-myc and N-ras. Immunocytochemi- cal analysis showed changes in protein products of c-myc hepatocellular carcinoma and its nan cancerous tissue were similar to those in mRNA expression. The same was true for the fetal liver during its development. A comparable study was also made on the ex pression of c-myc and N-ras oncogenes in limited samples of human pancreatic adenocarcinoma and its noncancerous tissue. The results are inconclu sive, and further studies are needed.     

Modified Scleral Flap Incision to Reduce Corneal Astigmatism after Intraocular Lens Implantation

To investigate a simple method during extracapsular cataract extraction with posterior chamber intraocular lens implantation in order to reduce surgically induced corneal astigmatism.Methods: A modified scleral flap incision was used in the extracapsular cataract extraction with intraocular lens implantation and the postoperative changes in conreal astigmatism was observed.Results: The peak value of postoperative corneal astigmatism was 3. 60 D, and the corneal astigmatism regression was 2. 11 D, surgically induced astigmatism was less significant in modified scleral flap incision group than that in conventional limbal incison group (P<0. 05).Conclusions: The modified scleral flap incision is an ideal incision for cataract extraction with intraocular lens implantation when phacoemulsifier is not available. Eye Science 1995; 11-. 136-139.     

末节手指骨骨折的治疗

1998年以来，我科在362例末节手指骨骨折的处理中，采用1枚7号针头作贯穿固定的方法，该法简便易行，疗效满意。     

一种新颖、敏感的蠕虫感染粪检方法

粪便寄生虫卵检查是临床诊断的基本手段，是肠道蠕虫流行病学调查的重要内容。Kato-Katz涂片法是检测人类曼氏血吸虫病的常规方法，因操作简便而普遍应用于流行区，以检测感染率和感染度及考核疗效，但其敏感性易受粪便性状的影响。在此介绍一种新的粪检方法——Percoll法。     

Effect of Ligustrazine on Bone Marrow Microenvironment and Signal Transducti on Path in Irradiation Injured Mice

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