艾滋病合并马尔尼菲青霉病江西首例报告

目的 分析艾滋病并发马尔尼菲青霉病的发病情况、临床特征、诊断要点。方法 对艾滋病合并马尔尼菲青霉病患者的临床资料进行总结。结果 艾滋病并发马尔尼菲青霉病的患者临床症状呈现多样性，但以马尔尼菲青霉病的表现为主。结论 艾滋病且易并发马尔尼菲青霉病，应引起临床高度重视。     

急性单核细胞白血病8年诊治回顾(附68例报告)

目的探讨急性单核细胞白血病的临床特征及不同方案、剂量的疗效.方法分析近8年医治的68例急性单核细胞白血病的临床资料.结果M5占同期收治急性髓细胞白血病的53.9%,30～50岁年龄多见,占55.9%.贫血及浸润症状表现明显.部分以全血细胞减少或高白细胞特征起病.总缓解率67.3%.结论老年M5患者多见全血细胞减少.DA（柔红霉素＋阿糖胞苷）方案较HA（高三尖杉酯碱＋阿糖胞苷）方案缓解率明显提高.强烈化疗对提高完全缓解（CR）率明显有益.     

全自动血压计智能校准仪的研发

为了提高血压计校准的速度和准确性,本产品运用新型压力传感器,特殊的8955单片机调压控制程序,很好的解决了血压计(表)的校准问题.     

Hyperbaric oxygenation induced tolerance against focal cerebral ischemia in mice is strain dependent

SV129 or C57BL/6 mice were exposed to hyperbaric oxygenation (HBO, 5 days, 1 h every day, 100% O(2) at 3 atm absolute). One day after the 5th HBO session focal cerebral ischemia was induced. In SV129 mice, HBO induced tolerance against permanent focal cerebral ischemia (n=42, mean infarct volume reduction 27%, P=0.001), but not against transient (30 or 60 min) focal cerebral ischemia. In the C57BL/6 strain of mice, HBO did not induce tolerance against focal cerebral ischemia, even when the duration of ischemia or the HBO protocol were modified. For the first time we demonstrate that HBO can induce tolerance to focal cerebral ischemia, but this effect is strain dependent.     

超声乳化吸除及人工晶状体植入术治疗小瞳孔白内障的临床探讨

目的:探讨小瞳孔时的白内障超声乳化术的手术技巧和临床效果。方法:对23例(27眼)散瞳后小瞳孔的白内障患者采用钝性分离及非切开的牵拉法扩大瞳孔,进行原位超声乳化并人工晶状体囊袋内植入术。结果:术后随访6～12mo,所有病例术后视力较术前有不同程度的提高,术后视力0.1～0.2者5眼,0.3～0.5者14眼;0.8以上者8眼。结论:采用钝性分离及非切开的牵拉扩大瞳孔法,原位超声乳化可使小瞳孔的白内障恢复良好的视力和生理性圆瞳孔或近圆瞳孔,手术并发症少。     

羊膜加巩膜前部覆盖防治羟基磷灰石义眼座眶内植入暴露的临床分析

目的:探讨羊膜加前部巩膜覆盖对防治羟基磷灰石(HA)义眼座植入暴露的临床效果。方法:采用羊膜联合自体或异体巩膜为加固物对13例(13眼)行Ⅰ、Ⅱ期HA义眼座植入,随访12～20mo。结果:13例均获得了较好的疗效,未见其他并发症。结论:在行HA义眼座植入时采用羊膜联合前部自体或异体巩膜覆盖加固有利于结膜创口的愈合,预防创口裂开,减少义眼座暴露。     

角膜新生血管形成机制研究进展

Campbell 1949年首先提出角膜新生血管(cornealne ovascularization，CNV)是由于角膜中存在一种能扩散的可溶性因子。现在已纯化、弄清序列并克隆成功了许多多肽类因子，不少因子具有复杂的生物学作用，这里统称为血管形成调节因子，一些小分子非肽类因子的性状尚在研究中。     

Immunobiologic, cytogenetic and drug response features of a newly established cell line (SCRC-1) from renal small cell carcinoma

PURPOSE: We describe the establishment and preliminary characterization of a cell line designated SCRC-1, which was derived from a primary renal small cell carcinoma. MATERIALS AND METHODS: Continuous cultures of a primary stage IVa renal small cell carcinoma and a xenograft in nude mice derived therefrom were characterized by immunohistology, electron microscopy, immunofluorescence/flow cytometry, cytogenetic analysis, and an in vitro drug resistance assay. RESULTS: SCRC-1 cells were reactive with antibodies to NSE, chromogranin-A, bombesin, Bcl-2, CD44s, CD44v6, CD44v7 to 8, vimentin and S100 protein (predominantly beta-subunit), and were unreactive with antibodies to EMA, CD54, EGFR(R1), URO-5, URO-7, URO-8 and URO-10. A similar immunoprofile was also found in both the primary tumor and the xenograft. Cytogenetic analysis revealed the following common clonal aberrations in all 50 metaphases analyzed: 45, XX, t (X;10;18) (p11;p11;q11), -der(18)t(X;10;18), indicating the clonal nature of this neoplasm. SCRC-1 cells showed low drug resistance to cyclophosphamide, doxorubicin, gemcitabine and fluorouracil, intermediate resistance to carmustine and mitomycin-C, and extreme resistance to cisplatin. CONCLUSION: We have documented the initial characterization of SCRC-1, which may be the first cell line reported to be derived from a primary small cell carcinoma of the kidney. This cell line can be used for further studies uncovering the biology and histogenesis of this rare cancer and delineating differences among small cell carcinomas of the kidney and other histological types.     

高效液相同时测定保健食品中两种结构形式洛伐他汀的含量

目的：建立保健食品中同时测定两种结构形式洛伐他汀含量的方法。方法：用高效液相色谱法同时测定含保健食品中两种结构形式洛伐他汀的含量。结果：方法线性范围为：0．500～0．025μg，最低检出限为0．001μg，总分析时间11min。洛伐他汀平均保留时间：闭环型9．632min，开环型8．682min。4种浓度的平均回收率为：97．77％。结论：高效液相色谱法同时测定洛伐他汀浓度稳定、可靠、简便，适用于保健食品的分析。     

抗单核细胞抗体与冠心病间关系的探讨

目的研究抗单核细胞抗体与冠心病的关系。方法以健康成人外周血单核细胞(MOC)为靶抗原,用微量间接酶免疫组织化学技术检测了35例冠心病(CHD)患者,27例献血员血清中抗单核细胞抗体(AMA)。结果冠心病组和献血员组血清中抗单核细胞抗体阳性率分别为54.3%、14.8%,平均滴度分别为1∶6.05、1∶2.63。病例组与对照组比较阳性率和平均滴度都明显增加(P<0.01),CHD患者血清稀释4倍AMA阳性率为48.6%,其四种临床类型AMA阳性率有差异,但不具显著性(P>0.05)。结论抗单核细胞抗体与冠心病有一定的关系。