以人为本 建立有效的医院人才激励机制

随着医疗市场的逐渐形成和完善，医疗市场已成为有序竞争的市场，并通过这个市场对医疗资源进行重新整合和配置。医院作为医疗市场竞争的主体，要在医疗市场中立于不败之地，必须对自己的资源进行优化，充分发挥自己的潜能，赢得竞争优势。医院资源中，最重要的资源是人才资源，医疗技术的发挥、医疗成果的取得、医疗服务的开展等一系列医疗活动都离不开医务工作者。因此，必须建立有效的人才激励机制，充分发挥人的主观能动性、调动人的积极因素，才能使医院在市场竞争中立于不败之地。本文结合医院人员结构特点及我院的实例，就如何建立以人为本的医院人才激励机制进行探讨。     

近年国内关于氧氟沙星不良反应的报道

氧氟沙星(Ofloxacin,商品名Tarivid)是第三代 喹诺酮类抗生素药物,其抗菌谱广,抗菌力强,细菌 耐药性低的特点而广泛用于临床。常见的不良反应 为恶心、呕吐、上腹部不适、头晕、头痛、失眠、皮疹、 血清转氨酶升高等。本文收集了几种少见的不良反 应,报道如下,应引起重视。     

The Application of Topical Anesthesia Combined with Subconjunctival Anesthesia for Glaucoma Surgery

Purpose: To evaluate the feasibility, reliability and analgesia effect of topical anesthesia combined with subconjunctival anesthesia in anti-glaucomatous surgery.Methods: Two hundred and four cases (357 eyes) underwent anti-glaucomatous surgeries under topical anesthesia with 0.5％ Alcaine eye drops combined with subconjunctival anesthesia with 2％ Lidocaine. The analgesic effect was analysed with visual analogue pain scale.Results: Among all of 357 eyes, 62 eyes underwent peripheral iridectomy, 67 eyes underwent simple trabeculectomy, 167 eyes underwent compound brabeculectomy and 12 eyes nonpenetrating trabecular surgery. The effects of anesthesia were as follows: 304 eyes (85.2％) were painless (Grade Ⅰ), 50 eyes (14.0％) were slight painful (Grade Ⅱ), and 3 eyes (0.8％) were more painful (Grade Ⅲ) during surgery. And no severe complications were observed in all the cases during surgery and postoperatively. Amaurosis fugax was not observed in the glaucoma patients at the late stage with narrow vi     

内分泌科中药注射液应用分析

目的：对医院内分泌科中药注射液的使用情况进行分析评估,为临床合理用药提供参考依据。方法：采用药物限定日剂量（DDD）分析方法,统计我院2008年10月～2009年9月内分泌科中药注射液的用药频度（DDDs）、销售金额等数据。结果：丹参川芎嗪的销售金额最高。DDDs排序位于前3位的分别是丹参川芎嗪、苦碟子、灯盏细辛。结论：医院内分泌科中药注射液中丹参川芎嗪占主要地位。     

枯草杆菌Bacillus sp F26产过氧化氢酶的发酵条件

从内蒙古呼伦贝尔草原的盐碱湖中分离到的一株低度嗜盐嗜碱细菌Bacillus sp F26，能积累高水平过氧化氢酶（CAT）。对Bacillus sp F26发酵产过氧化氢酶的环境与营养条件的研究结果表明，其积累高水平过氧化氢酶的适宜环境条件为：温度37℃，种龄20-22h，接种量5％，装液量50mL／（250mL的摇瓶）。适宜发酵培养基组成（g／L）为：葡萄糖15，牛肉膏10，玉米浆10，酵母膏5，磷酸二氢钾1，氯化镁0．2，氯化钠50，碳酸钠10。采用上述条件进行摇瓶分批发酵实验，发酵20h，过氧化氢酶酶活达到16．32U／mL，细胞干重为4．12g／L。进一步研究发现，在对数生长后期（16h）添加2mmol／L的H2O2可以明显刺激产酶，在5L的发酵罐上进一步以指数速率方式流加H2O2，由于该流加方式可降低H2O2对细胞的毒害作用，过氧化氢酶酶活达到29．89U／mL，与分批发酵相比提高了92．8％。     

GABAergic Interneurons at Supraspinal and Spinal Levels Differentially Modulate the Antinociceptive Effect of Nitrous Oxide in Fischer Rats

Background: The study hypothesizes that nitrous oxide (N2O) releases opioid peptide in the brain stem, which results in inhibition of [gamma]-aminobutyric acid-mediated (GABAergic) neurons that tonically inhibit the descending noradrenergic inhibitory neurons (DNIN), resulting in activation of DNIN. In the spinal cord, activation of DNIN leads to the release of norepinephrine, which inhibits nociceptive processing through direct activation of [alpha]2 adrenoceptor and indirect activation of GABAergic neurons through [alpha]1 adrenoceptor. Arising from this hypothesis, it follows that GABAergic neurons will modulate the antinociceptive effect of N2O in diametrically opposite directions at supraspinal and spinal levels. The authors have tested this tenet and further examined the effect of midazolam, a GABA-mimetic agent, on N2O-induced antinociceptive effect.

Methods: Adult male Fischer rats were administered muscimol (GABAA receptor agonist) intracerebroventricularly (icv), gabazine (GABAA receptor antagonist) intrathecally (intrathecal), or midazolam intraperitoneally (intraperitoneal). Fifteen minutes later, they were exposed to air or 75% N2O and were subjected to the plantar test after 30 min of gas exposure. In some animals administered with midazolam, gas exposure was continued for 90 min, and the brain and spinal cord were examined immunohistochemically.

Results: The N2O-induced antinociceptive effect, which was attenuated by icv muscimol, intrathecal gabazine, and intraperitoneal midazolam. Midazolam inhibited N2O-induced c-Fos expression (a marker of neuronal activation) in the pontine A7 and spinal cord.     

溴隐亭引起癫痫发作一例

溴隐亭是治疗高催乳素血症的首选药物，但其可引发癫痼发作，在临床上并不多见。我院2007年10月20日收治1例。现报告如下。     

机采血小板发生不良献血反应的原因和预防措施

目的探讨机采血小板献血反应原因及献血者献血反应率与循环血量、献血者体重、抗凝剂中毒等关系。方法对886名机采血小板献血者中发生献血反应的115人的情况详细记录，并进行分析。结果轻、中、重度反应率分别为11％、1．7％、0．22％；总循环血量〈2500mL、（2500～3000）mL、（3000-3500）mL、〉3500mL献血反应率分别为8．3％、15．4％、16．9％、29．2％；体重（45．50）kg、（51～60）kg、（61—70）kg、〉70kg，其献血反应率分别为38．2％、14．3％、12．6％、9．0％。首次、多次献血反应率分别为24％、5．2％。结论选择体重高、血小板计数高、多次献血者，可减少机采血小板献血者献血反应的发生。     

278例染色体异常的遗传学分析

目的:研究染色体异常与智力低下、习惯性流产夫妇、不育、不孕症、畸胎、死胎史的关系.方法:采用人类外周血淋巴细胞培养,G显带,核型分析.结果:共检出染色体异常278例,其中儿童智力低下病人中检出异常核型147例,占52.84%;习惯性流产、死胎史的病人中检出异常核型12例,占4.31%;不育、不孕的病人检出异常核型99例,占35.61%;原发闭经和继发闭经的病人检出异常核型18例,占6.47%.结论:染色体异常是引起智力低下,习惯性流产、不育不孕症、畸胎死胎史等重要原因之一.     

浅析动态探究式教学法

学校教育要突出“以学生发展为本”，就要围绕学生这个教育主体开展教学改革、探讨教学方法新思路。该结合高校“两课”教学实践，及时总结经验，提升理论高度，提出了动态探究式教学法，旨在尝试创新教学方式方法，活跃教学氛围、提高教学质量。