全文获取类型
收费全文 | 34786篇 |
免费 | 2779篇 |
国内免费 | 449篇 |
专业分类
耳鼻咽喉 | 370篇 |
儿科学 | 1016篇 |
妇产科学 | 613篇 |
基础医学 | 4984篇 |
口腔科学 | 519篇 |
临床医学 | 3321篇 |
内科学 | 7390篇 |
皮肤病学 | 763篇 |
神经病学 | 2596篇 |
特种医学 | 1306篇 |
外国民族医学 | 16篇 |
外科学 | 4239篇 |
综合类 | 1462篇 |
现状与发展 | 1篇 |
一般理论 | 2篇 |
预防医学 | 2743篇 |
眼科学 | 689篇 |
药学 | 2656篇 |
10篇 | |
中国医学 | 671篇 |
肿瘤学 | 2647篇 |
出版年
2023年 | 276篇 |
2022年 | 683篇 |
2021年 | 1134篇 |
2020年 | 701篇 |
2019年 | 858篇 |
2018年 | 1056篇 |
2017年 | 788篇 |
2016年 | 762篇 |
2015年 | 942篇 |
2014年 | 1208篇 |
2013年 | 1538篇 |
2012年 | 2207篇 |
2011年 | 2236篇 |
2010年 | 1387篇 |
2009年 | 1145篇 |
2008年 | 1647篇 |
2007年 | 1695篇 |
2006年 | 1623篇 |
2005年 | 1509篇 |
2004年 | 1346篇 |
2003年 | 1287篇 |
2002年 | 1210篇 |
2001年 | 1117篇 |
2000年 | 1109篇 |
1999年 | 987篇 |
1998年 | 351篇 |
1997年 | 304篇 |
1996年 | 266篇 |
1995年 | 214篇 |
1994年 | 212篇 |
1993年 | 174篇 |
1992年 | 518篇 |
1991年 | 499篇 |
1990年 | 475篇 |
1989年 | 432篇 |
1988年 | 453篇 |
1987年 | 382篇 |
1986年 | 372篇 |
1985年 | 365篇 |
1984年 | 257篇 |
1983年 | 187篇 |
1982年 | 119篇 |
1981年 | 103篇 |
1979年 | 210篇 |
1978年 | 111篇 |
1977年 | 124篇 |
1976年 | 113篇 |
1974年 | 130篇 |
1972年 | 128篇 |
1969年 | 104篇 |
排序方式: 共有10000条查询结果,搜索用时 8 毫秒
91.
The simian immunodeficiency virus is a retrovirus closely related to the human immunodeficiency viruses; it induces an AIDS-like disease in macaques, and provides therefore an obvious animal model for anti-lentiviral drug and vaccine strategy assessments. In our experiment, we immunized rhesus macaques with a purified and formalin-inactivated whole SIVmac251 antigen preparation. Most of these monkeys were still protected for more than 4 months following a heterologous SIVsm intravenous challenge. Both virus stocks, for vaccine preparation and challenge, were provided by culture supernatants of infected T cells of human origin. Four of the protected macaques were then reimmunized with the same antigen preparation and rechallenged intravenously with a homologous rhesus cell grown SIVmac251. Unexpectedly, all animals developed clinical and biological evidence of infection by day 15 after the second challenge. 相似文献
92.
目的:探讨用氨甲喋呤(Methotraxate,MTX)配伍中药治疗条件适宜的输卵管妊娠的可行性及疗效。方法:对MTX配伍中治疗的输卵管妊娠86例临床资料进行分析。结果:82例治疗成功,成功率为95.35%,其中,治疗1个疗程69例,2个疗程13例,随访16例妊娠,1例2年后对侧输卵管妊娠,4例治疗失败者改手术治疗,病理见不同程度的滋养细胞溶解,绒毛坏死,出血,结论:使用MTX配伍中药治疗输卵管异位妊娠,方法简便易行,安全有效,副作用少,特别适合于基层医院。 相似文献
93.
心肌缺血再灌注损伤时细胞核被膜钙泵活性特征的研究 总被引:1,自引:0,他引:1
目的 研究心肌缺血再灌注损伤时Ca2 + 、ATP、ADP和AMP对细胞核被膜钙泵 (Ca2 + ATPase)活性的调节。方法 采用大鼠心肌缺血再灌注模型 ,密度梯度分离纯化细胞核 ,定磷法测定Ca2 + ATPase活性。结果 与正常大鼠相比 ,缺血再灌注损伤动物血浆MDA和FFA显著升高 (P <0 0 1) ;细胞核Ca2 + ATPase活性下降 ,对Ca2 + 亲和力降低 ;ADP、AMP对核Ca2 + ATPase活性的影响明显减弱 ;ATP对Ca2 + ATPase的作用在 [ATP]小于 1 0mmol L时 ,与正常细胞Ca2 + AT Pase活性无显著差异 ,浓度增至 2 0mmol L时 ,活性低于正常细胞 ,ATP浓度继续增加 ,核Ca2 + ATPase活性快速增加。结论 心肌缺血再灌注损伤时Ca2 + 、ATP、ADP、AMP对心肌细胞核Ca2 + ATPase活性的影响发生了明显改变 ,其病理生理意义值得进一步探讨。 相似文献
94.
95.
计算机在医学领域中的应用及展望 总被引:2,自引:0,他引:2
对计算机在医学文献检索、医学统计软件包的编制、疾病诊断、医院管理等医学领域中的应用作了简要的综述,并对未来的发展进行了预测。 相似文献
96.
Further phenotypic evidence that nodular, lymphocyte-predominant Hodgkin's disease is a large B-cell lymphoma in evolution 总被引:4,自引:0,他引:4
S M Chittal C Alard J F Rossi T al Saati A Le Tourneau J Diebold G Delsol 《The American journal of surgical pathology》1990,14(11):1024-1035
Five cases of nodular, lymphocyte predominant Hodgkin's disease (nLP HD), in which an association with (n = 3) and transformation to (n = 2) large cell lymphoma (LCL) were found, were studied with monoclonal antibodies against B-, T-, and Reed-Sternberg (R-S) cell-associated antigens and epithelial membrane antigen (EMA) on paraffin sections. Both lymphocytic (L) and histiocytic (H) cells of nLP HD and lymphoma cells of LCL expressed multiple B-cell-associated antigens (detected by LN-1/CDw75, L26, MB2, DBB.42, DBA.44, DND.53, DNA.7 antibodies) but did not react with antibodies against T-cell-associated (MT1, UCHL1/CD45RO) (one exception for CD45RO in LCL) and R-S cell-associated (Leu-M1/CD15, Ber-H2/CD30) antigens. EMA was expressed by L and H cells in all cases and conserved in LCL cells, emphasizing the frequent expression of EMA by the diagnostic cells of nLP HD. An antibody (BNH9) against blood group-related antigens (H and Y oligosaccharide antigens) that does not normally react with lymphoid cells was found to be reactive with few L and H cells in two of five and most LCL cells in four of five cases. The finding might be indicative of abnormal activation of lymphoid cells. The data reinforce current implications that nLP HD is a B-cell malignancy in evolution and that it is not truly representative of Hodgkin's disease in terms of biological and clinical behavior. 相似文献
97.
98.
B Croisile B Laurent D Michel D Le Bars L Cinotti F Mauguière 《Revue neurologique》1991,147(3):192-199
The authors report 3 cases of slowly progressive aphasia with different language disturbances: anomia, pure word deafness and Broca's aphasia. All patients were independent in daily life activities. Insight, judgement and overall behaviour were intact. There was no major disturbance of other cognitive functions, but psychometric tests showed mild deficits suggesting widespread involvement. CT scans and magnetic resonance imaging showed focal dilatation of the left sylvian fissure. A positron emission tomographic study showed left perisylvian hypometabolism. A review of the literature yielded an increasing number of cases of this degenerative syndrome affecting dominant hemisphere language areas. Our cases confirm the clinical heterogeneity of degenerative aphasia. Postmortem neuropathological examinations are rare and many causes are found: Pick's disease, Alzheimer's disease or aspecific gliosis. 相似文献
99.
100.