全文获取类型
收费全文 | 4922篇 |
免费 | 463篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 237篇 |
妇产科学 | 65篇 |
基础医学 | 572篇 |
口腔科学 | 97篇 |
临床医学 | 550篇 |
内科学 | 984篇 |
皮肤病学 | 68篇 |
神经病学 | 346篇 |
特种医学 | 285篇 |
外科学 | 633篇 |
综合类 | 146篇 |
一般理论 | 3篇 |
预防医学 | 468篇 |
眼科学 | 132篇 |
药学 | 338篇 |
中国医学 | 10篇 |
肿瘤学 | 461篇 |
出版年
2023年 | 26篇 |
2022年 | 53篇 |
2021年 | 107篇 |
2020年 | 56篇 |
2019年 | 120篇 |
2018年 | 98篇 |
2017年 | 71篇 |
2016年 | 100篇 |
2015年 | 111篇 |
2014年 | 145篇 |
2013年 | 231篇 |
2012年 | 264篇 |
2011年 | 254篇 |
2010年 | 190篇 |
2009年 | 154篇 |
2008年 | 230篇 |
2007年 | 231篇 |
2006年 | 252篇 |
2005年 | 240篇 |
2004年 | 229篇 |
2003年 | 230篇 |
2002年 | 172篇 |
2001年 | 182篇 |
2000年 | 144篇 |
1999年 | 121篇 |
1998年 | 81篇 |
1997年 | 70篇 |
1996年 | 72篇 |
1995年 | 61篇 |
1994年 | 49篇 |
1993年 | 52篇 |
1992年 | 65篇 |
1991年 | 65篇 |
1990年 | 50篇 |
1989年 | 63篇 |
1988年 | 56篇 |
1987年 | 73篇 |
1986年 | 43篇 |
1985年 | 50篇 |
1984年 | 33篇 |
1983年 | 34篇 |
1982年 | 29篇 |
1981年 | 27篇 |
1980年 | 26篇 |
1978年 | 28篇 |
1977年 | 38篇 |
1976年 | 29篇 |
1975年 | 27篇 |
1974年 | 28篇 |
1972年 | 32篇 |
排序方式: 共有5417条查询结果,搜索用时 593 毫秒
991.
992.
993.
994.
995.
Ka Ling Rosalina Ip Jason Chi-Chiu So Man-Fai Law Raymond S. M. Wong Ho Chi Tam Margaret H. L. Ng 《Hemoglobin》2016,40(4):260-263
Hb Tarrant [α126(H9)Asp→Asn; HBA2: c.379G?>?A (or HBA1)], is a rare high oxygen affinity hemoglobin (Hb) variant that causes erythrocytosis, previously described in a few Mexican–American families. Here we report the first Chinese family with this Hb variant presenting with unexplained familial erythrocytosis. No evidence of hemolysis was seen. A locally adapted approach to the diagnostic process in clinical laboratories is discussed. Molecular analysis has an important role in confirmation of the diagnosis. Proper identification of this rare but clinically significant Hb variant is helpful for family counseling and will help to guide appropriate management of absolute erythrocytosis. 相似文献
996.
Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam 《World journal of gastroenterology : WJG》2016,22(28):6484-6500
Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. 相似文献
997.
Spontaneous circumferential intramural esophageal dissection complicated with esophageal perforation and esophageal‐pleural fistula: a case report and literature review 下载免费PDF全文
Spontaneous intramural esophageal dissection (IED) is a rare disease entity. There are few reports of spontaneous IED requiring surgical treatment. Hereby, we report a 37‐year‐old gentleman who was diagnosed to have spontaneous extensive circumferential IED complicated with esophageal perforation, empyema, and esophageal‐pleural fistula. Esophageal stenting and drainage of empyema were unsuccessful. Computed tomography and gastrografin contrast swallow demonstrated a leak to the pleural cavity, suggestive of esophageal‐pleural fistula. Subsequently, a two‐stage operation was performed: cervical esophagogastrostomy to bypass the perforated esophagus, followed by esophagectomy and decortication of the right lung. The patient recovered and was discharged home after a 3‐week hospitalization. The management principles and recent published literature related to IED were reviewed. 相似文献
998.
通过回顾香港地区肿瘤放射治疗设备、人员、技术等情况的进展,可为广大读者提供一个简单清晰的脉络,并帮助了解香港地区肿瘤放射治疗学创建与发展过程。此报告是对香港地区肿瘤放射治疗学发展的宣传与肯定,也更是为扩大放射肿瘤学科交流和发展提供契机。 相似文献
999.
Field, coil, and echo-time influence on sensitivity and reproducibility of brain proton MR spectroscopy 总被引:2,自引:0,他引:2
Inglese M Spindler M Babb JS Sunenshine P Law M Gonen O 《AJNR. American journal of neuroradiology》2006,27(3):684-688
BACKGROUND AND PURPOSE: Clinical MR imaging scanners now offer many choices of hardware configurations that were not available in the first 25 years of their existence. Our goal was to assess the influence of coil technology, magnetic field strength, and echo time (TE) on the sensitivity, reflected by the signal intensity-to-noise-ratio (SNR) and reproducibility of proton MR spectroscopy (1H-MR spectroscopy). MATERIAL AND METHODS: The SNR, the intersubject reproducibility, and the intrasubject reproducibility of N-acetylaspartate (NAA), creatine (Cr), and choline (Cho) levels were compared at the common TEs of 30, 144, and 288 ms, by using 1H-MR spectroscopy in 6 volunteers at (1) 3T with a single-element quadrature (SEQ); (2) 1.5T with SEQ; and (3) 1.5T with a 12-channel phased-array (PA) head coil. RESULTS: In terms of sensitivity, the best SNR for all metabolites was obtained at the shortest TE (30 ms). It was comparable between the 3 and 1.5T with the PA, but approximately 35% better than the 1.5T with SEQ. This SNR difference declined <25% at TE of 144 ms and to equity among all imagers at TE of 288 ms. Reproducibility, reflected in the coefficient of variation (CV), was best for NAA at TE of 288 ms, 15%-50% better than at TE of 30 ms in either gray (GM) or white matter (WM). The CV for Cr was best, at TE of 288 ms for GM, but its WM results were independent of TE. Metabolite level reproducibility did not depend on coil technology or magnetic field strength. CONCLUSIONS: For the same coil type, the SNR of all major metabolites was approximately 35% better at 3T than at 1.5T. This advantage, however, was offset at 1.5T with a PA coil, making it a cost-effective upgrade for existing scanners. Surprisingly and counterintuitively, despite the lowest SNR, the best reproducibility was obtained at the longest TE (288 ms), regardless of field or coil. 相似文献
1000.
Hesseltine SM Law M Babb J Rad M Lopez S Ge Y Johnson G Grossman RI 《AJNR. American journal of neuroradiology》2006,27(6):1189-1193
BACKGROUND AND PURPOSE: Evaluation of the spinal cord is important in the diagnosis and follow-up of patients with multiple sclerosis. Our purpose was to investigate diffusion tensor imaging (DTI) changes in different regions of normal-appearing spinal cord (NASC) in relapsing-remitting multiple sclerosis (RRMS). METHODS: Axial DTI of the cervical spinal cord was performed in 24 patients with RRMS and 24 age- and sex-matched control subjects. Fractional anisotropy (FA) and mean diffusivity (MD) were calculated in separate regions of interest (ROIs) in the anterior, lateral, and posterior spinal cord, bilaterally, and the central spinal cord, at the C2-C3 level. Patients and control subjects were compared with respect to FA and MD with the use of an exact Mann-Whitney test. Logistic regression and receiver operating characteristic (ROC) curve analysis assessed the utility of each measure for the diagnosis of RRMS. RESULTS: DTI metrics in areas of NASC in MS were significantly different in patients compared with control subjects; FA was lower in the lateral (mean +/- SD of 0.56 +/- 0.10 versus 0.69 +/- 0.09 in control subjects, P < .0001), posterior (0.52 +/- 0.11 versus 0.63 +/- 0.10, P < .0001), and central (0.53 +/- 0.10 versus 0.58 +/- 0.10, P = .049) NASC ROIs. Assessing DTI metrics in the diagnosis of MS, a sensitivity of 87.0% (95% confidence interval [CI], 66.4 to 97.1) and a specificity of 91.7% (95% CI, 73.0 to 98.7) were demonstrated. CONCLUSION: The NASC in RRMS demonstrates DTI changes. This may prove useful in detecting occult spinal cord pathology, predicting clinical course, and monitoring disease progression and therapeutic effect in MS. 相似文献