可逆性后部白质脑病综合征患者临床表现与磁共振影像学特点分析

目的分析可逆性后部白质脑病综合征(RPLS)患者的临床表现及磁共振(MRI)影像学特点。方法回顾性分析115例RPLS患者的临床及影像学资料。结果 115例RPLS患者表现为血压升高(89.56%)、痫性发作(74.78%)、头痛(59.13%)、视觉障碍(32.17%)、神经系统体征(20.00%)和意识改变(15.65%),其中101例(87.83%)患者头颅MRI异常,累及枕叶(71.29%)、顶叶(59.40%)、额叶(49.50%)、颞叶(38.26%)、侧室脑旁(1.98%)、脑干(3.96%)、小脑(3.96%)、皮质(3.96%)、丘脑(0.99%)、基底节区(0.99%),病灶为等或低T1WI信号,高T2WI信号,等或低DWI信号,高ADC及FLAIR信号。治疗后随访3～60月,81例预后良好,21例预后不良,5例死亡。预后不良组头痛发生率、住院期间m RS评分≥3分及并发症比例高于预后良好组(P<0.05)。结论 RPLS的MRI表现具有特征性,结合临床表现可作出正确判断,及时治疗,改善预后。     

自我干预强化点检表对前列腺手术患者自护能力与心理韧性及并发症的影响

目的：自我干预强化点检表对前列腺手术患者自护能力与心理韧性及并发症的影响。方法：选取2019年5月～2021年6月在我院126例前列腺手术患者作为研究对象,按照随机数字表法分为对照组(予以常规护理干预)与观察组(在常规护理干预的基础上予以自我干预强化点检表),各63例,对比自我护理能力测定量表(ESCA)、心理韧性量表;观察并发症(尿路感染、尿道狭窄、尿潴留、尿失禁、尿频)。结果：入院时,两组患者 ESCA评分、心理韧性评分(坚韧、乐观、自强)比较差异无统计学意义;出院后3个月,观察组的ESCA评分、心理韧性评分(坚韧、乐观、自强)高于对照组。观察组患者的并发症总发生率低于对照组。结论：自我干预强化点检表有利于提高前列腺手术患者的自护能力与心理韧性,以及降低并发症发生率。     

Accelerated-strategy renal replacement therapy for critically ill patients: A systematic review and meta-analysis

Background:The aim of this study was to investigate the clinical effect and safety of accelerated-strategy initiation of renal replacement therapy (RRT) in critically ill patients.Methods:PubMed, Embase, OVID, EBSCO, and the Cochrane Library databases were searched for relevant articles from inception to December 30, 2020. Only RCTs that compared the clinical efficacy and safety between accelerated-strategy RRT and standard-strategy RRT among critically ill adult patients with acute kidney injury (AKI) were included. The primary outcome was 28-day mortality.Results:A total of 5279 patients in 12 RCTs were included in this meta-analysis. The 28-day mortality rates of patients treated with accelerated and standard RRT were 37.3% (969/2596) and 37.9% (976/2573), respectively. No significant difference was observed between the groups (OR, 0.92; 95% CI, 0.70–1.12; I² = 60%). The recovery rates of renal function were 54.5% and 52.5% in the accelerated- and standard-RRT groups, respectively, with no significant difference (OR, 1.03; 95% CI, 0.89–1.19; I² = 56%). The rate of RRT dependency was similar in the accelerated- and standard-RRT strategies (6.7% vs 5.0%; OR, 1.11; 95% CI, 0.71–1.72; I² = 20%). The accelerated-RRT group displayed higher risks of hypotension, catheter-related infection, and hypophosphatemia than the standard-RRT group (hypotension: OR, 1.26; 95% CI, 1.10–1.45; I² = 36%; catheter-related infection: OR, 1.90; 95% CI, 1.17–3.09; I² = 0%; hypophosphatemia: OR, 2.11; 95% CI, 1.43–3.15; I² = 67%).Conclusions:Accelerated RRT does not reduce the risk of death and does not improve the recovery of kidney function among critically ill patients with AKI. In contrast, an increased risk of adverse events was observed in patients receiving accelerated RRT. However, these findings were based on low quality of evidence. Further large-scale RCTs is warranted.     

中国女性与日本女性股骨颈几何参数的比较

目的：股骨颈脆性骨折是后果最严重、医疗花费最高和病死率最高的骨质疏松性骨折类型。股骨颈几何参数(femoral neck geometric parameters,FNGPs)是反映股骨颈几何学特征的重要参数,与股骨颈强度和脆性骨折风险密切相关。股骨颈脆性骨折的发病率存在明显的种族差异,但FNGPs是否有种族差异尚未明确。本研究旨在比较中国女性与日本女性FNGPs的差异。方法：本研究为横断面研究,从湖南省长沙市及周边地区招募女性健康志愿者3 859名,年龄为10.0～86.0(45.7±17.1)岁。测量并记录研究对象的体重、身高,并计算其体重指数(body mass index,BMI),采用双能X线骨密度测量仪测量研究对象的股骨颈投射骨面积(bone area, BA)和股骨颈骨密度(bone mineral density,BMD)。采用BA和/或BMD计算各种FNGPs,包括股骨颈轴长中点的外周直径(outer diameter,OD)、横截面积(cross-sectional area,CSA)、平均皮质厚度(cortical thickness,CT)、内皮质直径(endo...     

GO/iron series systems enhancing the pH shock resistance of anaerobic systems for sulfate-containing organic wastewater treatment

In this study, the effect of pH shock during the treatment of sulfate-containing organic wastewater was investigated using an anaerobic fermentation system reinforced with graphene oxide (GO)/iron series systems. The results show that the anaerobic system with the GO/iron series systems exhibited enhanced resistance to pH shock. Among them, the GO/Fe⁰ system had the strongest resistance to pH shock, the systems of GO/Fe₃O₄ and GO/Fe₂O₃ followed close behind, while the blank system performed the worst. After pH shock, the COD_Cr removal rate, SO₄²⁻ removal rate, and gas production of the GO/Fe⁰ group were significantly improved compared with those of the control group by 51.0%, 65.3%, and 34.6%, respectively, while the accumulation of propionic acid was the lowest. Further, detailed microbial characterization revealed that the introduction of the GO/iron series systems was beneficial to the formation of more stable anaerobic co-metabolic flora in the system, and the relative abundance of Geobacter, Clostridium, Desulfobulbus and Desulfovibrio increased after acidic and alkaline shock.

In this paper, we studied the pH shock resistance mechanism of GO/iron series from the perspectives of the treatment effect, changes in effluent pH and VFA, and microbial co-metabolic stability, providing a reference for the practical application.     

缺氧对成熟脂肪细胞去分化影响的实验研究

目的 研究缺氧环境下成熟脂肪细胞体外培养的形态学变化,探讨缺氧环境对成熟脂肪细胞去分化的影响.方法 从成人吸脂术后抽吸物提取脂肪组织来源的干细胞,诱导为成熟脂肪细胞,在缺血缺氧的环境下培养.观察各时间段细胞的形态变化.结果 由脂肪组织来源的干细胞诱导而成的成熟脂肪细胞,在缺氧环境培养数日后,细胞从圆形变为可持续分裂的成纤维细胞状细胞.结论 成熟的脂肪细胞在一定条件下可以去分化为成纤维细胞状细胞.     

复方鲜药外敷治疗肿瘤性溃疡伤口临床研究

目的:观察复方鲜药外敷对肿瘤性溃疡伤口的治疗效果.方法 :选取肿瘤性溃疡伤口患者60例,按随机数字表法分为观察组和对照组各30例.对照组给予常规护理及芦荟外敷,观察组给予常规护理联合复方鲜药外敷.观察2组肿瘤性溃疡伤口愈合面的大小、视觉模拟评分(VAS)、恶臭评分、生存期、生活质量等指标变化情况.结果 :护理后,观察组...     

穴位贴敷联合逍遥散加减治疗经前期综合征的临床研究

目的 探讨穴位贴敷联合逍遥散加减治疗经前期综合征（PMS）的临床效果。方法 选取2019年11月至2021年11月新余市中医院收治的60例肝郁型PMS患者作为研究对象,采用抽签法将其分为单一组与联合组,每组各30例。单一组患者采用逍遥散加减治疗,联合组患者采用逍遥散加减治疗联合穴位贴敷治疗。比较两组患者的中医证候积分、治疗效果、汉密尔顿焦虑量表（HAMA）评分。结果 治疗后,两组患者的中医证候积分均低于治疗前,差异有统计学意义（P<0.05）;治疗后,联合组患者的中医证候积分低于单一组,差异有统计学意义（P<0.05）。联合组患者的总有效率高于单一组,差异有统计学意义（P<0.05）。治疗后,两组患者的HAMA评分均低于治疗前,差异有统计学意义（P<0.05）;治疗后,联合组患者的HAMA评分低于单一组,差异有统计学意义（P<0.05）。结论 穴位贴敷联合逍遥散加减治疗能够明显改善PMS相关症状,改善患者焦虑情绪。     

长效抗菌材料联合蒙脱石散治疗老年卧床失禁性皮炎的效果

目的 探讨长效抗菌材料联合蒙脱石散治疗老年卧床失禁性皮炎的效果。方法 选取2019年2月至2020年12月江西省赣南医学院第一附属医院心血管内科收治的66例老年卧床失禁性皮炎患者作为研究对象,采用摸球法分为常规组和观察组,各33例。常规组采用蒙脱石散治疗,观察组采用蒙脱石散联合长效抗菌材料治疗,比较两组患者的临床指标、疗效、生活质量及皮肤愈合情况。结果 治疗前两组患者生活质量评分比较,差异无统计学意义（P>0.05）;治疗后观察组生活质量评分高于常规组,差异有统计学意义（P<0.05）。观察组治疗时间及愈合时间均短于常规组,差异有统计学意义（P<0.05）。观察组的皮肤损伤情况优于常规组,差异有统计学意义（P<0.05）。观察组治疗总有效率高于常规组,差异有统计学意义（P<0.05）。结论 长效抗菌材料联合蒙脱石散用于老年卧床失禁性皮炎患者的治疗效果显著,能有效改善患者生活质量,提升临床效果,同时减少皮肤损伤,进而缩短患者治疗时间,值得推广。     

The Potential Roles of Dietary Anthocyanins in Inhibiting Vascular Endothelial Cell Senescence and Preventing Cardiovascular Diseases

Cardiovascular disease (CVD) is a group of diseases affecting the heart and blood vessels and is the leading cause of morbidity and mortality worldwide. Increasingly more evidence has shown that the senescence of vascular endothelial cells is the key to endothelial dysfunction and cardiovascular diseases. Anthocyanin is a type of water-soluble polyphenol pigment and secondary metabolite of plant-based food widely existing in fruits and vegetables. The gut microbiome is involved in the metabolism of anthocyanins and mediates the biological activities of anthocyanins and their metabolites, while anthocyanins also regulate the growth of specific bacteria in the microbiota and promote the proliferation of healthy anaerobic flora. Accumulating studies have shown that anthocyanins have antioxidant, anti-inflammatory, and anti-aging effects. Many animal and in vitro experiments have also proven that anthocyanins have protective effects on cardiovascular-disease-related dysfunction. However, the molecular mechanism of anthocyanin in eliminating aging endothelial cells and preventing cardiovascular diseases is very complex and is not fully understood. In this systematic review, we summarize the metabolism and activities of anthocyanins, as well as their effects on scavenging senescent cells and cardioprotection.