全文获取类型
收费全文 | 295篇 |
免费 | 19篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 14篇 |
妇产科学 | 3篇 |
基础医学 | 23篇 |
口腔科学 | 9篇 |
临床医学 | 27篇 |
内科学 | 65篇 |
皮肤病学 | 13篇 |
神经病学 | 12篇 |
特种医学 | 63篇 |
外科学 | 33篇 |
综合类 | 25篇 |
预防医学 | 11篇 |
眼科学 | 1篇 |
药学 | 9篇 |
肿瘤学 | 7篇 |
出版年
2022年 | 1篇 |
2019年 | 2篇 |
2018年 | 5篇 |
2017年 | 4篇 |
2016年 | 4篇 |
2015年 | 1篇 |
2014年 | 6篇 |
2013年 | 8篇 |
2012年 | 3篇 |
2011年 | 7篇 |
2010年 | 10篇 |
2009年 | 10篇 |
2008年 | 14篇 |
2007年 | 14篇 |
2006年 | 11篇 |
2005年 | 15篇 |
2004年 | 15篇 |
2003年 | 12篇 |
2002年 | 4篇 |
2001年 | 2篇 |
1999年 | 3篇 |
1998年 | 17篇 |
1997年 | 23篇 |
1996年 | 14篇 |
1995年 | 11篇 |
1994年 | 5篇 |
1993年 | 8篇 |
1992年 | 2篇 |
1990年 | 2篇 |
1989年 | 6篇 |
1988年 | 6篇 |
1987年 | 6篇 |
1986年 | 6篇 |
1985年 | 19篇 |
1984年 | 8篇 |
1983年 | 3篇 |
1982年 | 6篇 |
1981年 | 7篇 |
1980年 | 5篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1949年 | 1篇 |
排序方式: 共有316条查询结果,搜索用时 15 毫秒
91.
FMRP is associated to the ribosomes via RNA 总被引:8,自引:8,他引:8
Tamanini F; Meijer N; Verheij C; Willems PJ; Galjaard H; Oostra BA; Hoogeveen AT 《Human molecular genetics》1996,5(6):809-813
92.
抗肿瘤药物研究Ⅰ:去甲斑蝥素氨基酸衍生物的合成与抗癌活性 总被引:1,自引:0,他引:1
In order to search for new compounds with higher anti-cancer activities and lower toxicities, 19 amino acid derivatives of norcantharidin, of which 16 are unknown compounds, were designed and synthesized. Preliminary screening results revealed that 2-(syn-exo-7-oxabicyclo [2. 2. 1] heptane-2, 3-dicarboxylic imido)-N-phenyl glutaramic acid exhibited a fairly apparent inhibitory activity against human-hepatoma cells in vitro (inhibitory rate 39.4% at 0.025 μtmol/ml). 相似文献
93.
We describe a new pyeloureteral drainage catheter that can be used for both genitourinary tract stenting and drainage, as well as tamponade of bleeding from the renal parenchyma or subcutaneous tissue. Primary indications for the use of this catheter and recommendations on insertion techniques are presented. With the exception of one case of minor kinking of the catheter, we have had no complications or failures with this catheter. While insertion through an unprotected tissue track is somewhat difficult, we have had good success introducing the catheter through a 24-F or larger Teflon working sheath. The catheter has excellent patient retention properties. It can be converted from external to internal drainage or vice versa simply and quickly on the ward. 相似文献
94.
1 OverviewoffemalemalignanciesinEuropeCancerincidenceandmortalityestimatesfor 1995werereportedrecentlyfor 38countriesinEurope[1] .Therewereestimated 2 .6millionnewcasesofcancerinEuropein 1995 ,representingoverone quarteroftheworldburdenofcancerwhileEurope’sinhabi… 相似文献
95.
Efstathios?J.?BoviatsisEmail author Andreas?T.?Kouyialis George?Stranjalis Stefanos?Korfias Damianos?E.?Sakas 《Neurosurgical review》2003,26(26-4):206-209
The effective treatment of intracranial abscess remains controversial. Progress in technology, linked with the development of neuronavigational systems, has made stereotactic aspiration and drainage of intracerebral abscesses effective and valid alternatives to traditional methods, namely, conservative medical treatment or open surgical excision. Between 1995 and 2002, 12 patients at our hospital underwent drainage of intracerebral abscesses under stereotactic guidance. Ten patients had solitary lesions and two had multiple abscesses. The appropriate antibiotic schemes were administered following culture of the aspirated material. The size of the abscess, the mass effect, and response to antibiotic treatment were followed up by repeated CT scans. All patients showed improvement and, at the end of treatment, returned to their previous activities. There were neither deaths nor any postoperative complication. A second aspiration was required in one patient due to recurrence of the abscess. The CT-guided stereotactic aspiration of brain abscesses helps achieve all treatment goals. It drains the contents of the abscess, reduces mass effect, and confirms diagnosis. It is minimally invasive, carries minimal morbidity and mortality, and can be performed on compromised patients under local anesthesia. 相似文献
96.
CT-guided stereotactic aspiration of brain abscesses 总被引:11,自引:0,他引:11
The effective treatment of intracranial abscess remains controversial. Progress in technology, linked with the development
of neuronavigational systems, has made stereotactic aspiration and drainage of intracerebral abscesses effective and valid
alternatives to traditional methods, namely, conservative medical treatment or open surgical excision. Between 1995 and 2002,
12 patients at our hospital underwent drainage of intracerebral abscesses under stereotactic guidance. Ten patients had solitary
lesions and two had multiple abscesses. The appropriate antibiotic schemes were administered following culture of the aspirated
material. The size of the abscess, the mass effect, and response to antibiotic treatment were followed up by repeated CT scans.
All patients showed improvement and, at the end of treatment, returned to their previous activities. There were neither deaths
nor any postoperative complication. A second aspiration was required in one patient due to recurrence of the abscess. The
CT-guided stereotactic aspiration of brain abscesses helps achieve all treatment goals. It drains the contents of the abscess,
reduces mass effect, and confirms diagnosis. It is minimally invasive, carries minimal morbidity and mortality, and can be
performed on compromised patients under local anesthesia. 相似文献
97.
98.
99.
100.
Temperature-dependent effects of EDTA on the membrane glycoprotein IIb- IIIa complex and platelet aggregability 总被引:6,自引:0,他引:6
In agreement with previous studies, we observed that incubation of washed human platelets with EDTA at 37 degrees C for short periods caused an irreversible loss of their aggregation response to adenosine diphosphate and markedly diminished their capacity to bind fibrinogen. AP-2 is a monoclonal antibody that reacts with a determinant specific to the glycoprotein (GP) IIb-IIIa complex. We now report that in a direct binding assay, the number of sites for AP-2 on platelets incubated with EDTA at 37 degrees C fell to approximately 30% of those present on control platelets. This effect of EDTA was not observed at room temperature. Analysis of the treated platelets by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed normal amounts of GP IIb and GP IIIa. However, studies using crossed immunoelectrophoresis with 125I-AP-2, 125I-Tab (anti-GP IIb), or 125I- AP-3 (anti-GP IIIa) in intermediate gels showed that at 37 degrees C, EDTA was inducing an irreversible change in GP IIb-IIIa complexes. A reduction in size and probable dissociation of the GP IIb-IIIa precipitate was accompanied by the appearance of precipitates having the characteristics of those given by free GP IIb and free GP IIIa and the location of a major new cathodal precipitate, which bound Tab and AP-3 but not AP-2. Membrane modifications associated with the loss of antigenic determinants on GP IIb-IIIa may explain EDTA-induced loss of platelet aggregability at 37 degrees C. 相似文献