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81.
Tetsuya Kumagai Haruko Kashiwamura Mari Katsumata Masao Ozaki 《Pediatric Dental Journal》2021,31(1):86-91
ObjectivePrevention is difficult to decrease dental caries only via the partial application of fluoride. The GC Co. has developed a coating material adhesive containing fluoride and zinc. It is thought that this zinc has an effect which prevents dental caries. The aim of this study was to evaluate the influence of the Caredyne Shield® (CS) on biofilm generation by S. mutans, as compared to an acidulated phosphate fluoride (APF) gel.Materials and methodsWe performed the comparative study of the biofilm inhibitory effect which used the enamel of bovine teeth. Specimens were separated into a control group, an APF gel group, and a CS group. Biofilms were generated by adherent S. mutans. We observed the antibacterial weigh by the creation state of Biofilms.ResultsSignificant difference was observed in the number of bacterial colonies formed after 24 h, the number of bacterial colonies formed from detached S. mutans from the CS-treated experimental group were fewer in number than in the other group (p < 0.01). The biofilm formed by S. mutans 72 h after dissemination on the enamel surface was visible by fluorescence microscopy (Live/Dead staining method) and under the scanning electron microscope, in the CS-treated group, no plastic structures were observed, as the models were free of the biofilm and only scattered S. mutans cells were observed.ConclusionWe showed in this study the efficacy of CS in controlling the formation of biofilm. From such a result, we conclude that CS is a novel anticaries agent. 相似文献
82.
Kotaro Sugimoto Akira Takasawa Shingo Ichimiya Masaki Murata Hiromichi Kimura Tomoyuki Aoyama Johan J.P. Gille Naoto Kuroda Hiroshi Shimizu Tadashi Hasegawa Norimasa Sawada Mitsuko Furuya Yoji Nagashima 《Pathology international》2013,63(10):510-515
Chromophobe renal cell carcinoma (RCC) accounts for approximately 5% of renal epithelial neoplasms. Multiple and/or bilateral chromophobe RCCs in an individual are generally rare but frequently occur in patients with Birt–Hogg–Dubé syndrome (BHDS) and in patients with tuberous sclerosis complex (TSC). The responsible genes in both BHDS and TSC act as tumor suppressors. Therefore, it seems that some genetic backgrounds are required for the generation and progression of multiple chromophobe RCCs. Here, we report a case of multiple and bilateral chromophobe RCCs along with several small‐sized capsular angiomyolipomas known as ‘capsulomas’ in a 39‐year‐old woman who had neither a particular medical history nor specific gene mutation. There has been no report of sporadic multiple chromophobe RCCs and ‘capsulomas’ developing in a patient without genetic features, having potential for novel genetic variation. 相似文献
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84.
Intramembranous bone regeneration differs among common inbred mouse strains following marrow ablation 下载免费PDF全文
Meghan M. Moran Amarjit S. Virdi Kotaro Sena Steven R. Mazzone Margaret A. McNulty Dale R. Sumner 《Journal of orthopaedic research》2015,33(9):1374-1381
Various intact and post‐injury bone phenotypes are heritable traits. In this study, we sought to determine if intramembranous bone regeneration following marrow ablation differed among common inbred mouse strains and to identify how early the differences appear. We found a ~four‐fold difference in the regenerated bone volume 21 days after marrow ablation in females from four inbred mouse strains: FVB/N (15.7 ± 8.1%, mean and standard deviation), C3H/He (15.5 ± 4.2%), C57BL/6 (12.2 ± 5.2%), and BALB/c (4.0 ± 4.4%); with BALB/c different from FVB/N (p = 0.007) and C3H/He (p = 0.002). A second experiment showed that FVB/N compared to BALB/c mice had more regenerated bone 7 and 14 days after ablation (p < 0.001), while at 21 days FVB/N mice had a greater fraction of mineralizing surface (p = 0.008) without a difference in mineral apposition rate. Thus, differences among strains are evident early during intramembranous bone regeneration following marrow ablation and appear to be associated with differences in osteogenic cell recruitment, but not osteoblast activity. The amount of regenerating bone was not correlated with other heritable traits such as the intact bone phenotype or soft tissue wound healing, suggesting that there may be independent genetic pathways for these traits. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1374–1381, 2015. 相似文献
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Masato Kaku Hiroshi Shimasue Junji Ohtani Shunichi Kojima Hiromi Sumi Hanaka Shikata Shotoku Kojima Masahide Motokawa Tahsin Raquib Abonti Toshitsugu Kawata Kazuo Tanne Kotaro Tanimoto 《The Angle orthodontist》2015,85(3):518
This case report describes the treatment of a skeletal Class III malocclusion with autotransplantation of a cryopreserved tooth. To gain an esthetic facial profile and good occlusion, extraction of bimaxillary premolars and surgical therapy were chosen. The patient had chronic apical periodontitis on the lower left first molar. Although she did not feel any pain in that region, the tooth was considered to have a poor prognosis. Therefore, we cryopreserved the extracted premolars to prepare for autotransplantation in the lower first molar area because the tooth would probably need to be removed in the future. The teeth were frozen by a programmed freezer with a magnetic field (CAS freezer) that was developed for tissue cryopreservation and were cryopreserved in −150°C deep freezer. After 1.5 years of presurgical orthodontic treatment, bilateral sagittal split ramus osteotomy was performed for mandible setback. Improvement of the facial profile and the occlusion were achieved in the retention phase. Six years after the initial visit, the patient had pain on the lower left first molar, and discharge of pus was observed, so we extracted the lower left first molar and autotransplanted the cryopreserved premolar. Three years later, healthy periodontium was observed at the autotransplanted tooth. This case report suggests that long-term cryopreservation of teeth by a CAS freezer is useful for later autotransplantation, and this can be a viable technique to replace missing teeth. 相似文献
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89.
Lack of an association between T-wave alternans and ST-segment depression during exercise-induced ambulatory ischemia 总被引:1,自引:0,他引:1
Ikeda T Kumagai K Takami M Tezuka N Nakae T Sakata T Noro M Enjoji Y Sugi K Yamaguchi T 《Journal of electrocardiology》2000,33(3):261-267
It is known that T-wave alternans (TWA), which identify patients at risk for arrhythmic events, often occur during acute coronary occlusion in association with ST-segment elevation. To test the hypothesis that TWA is associated with a certain state/severity of myocardial infarction/ischemia, we assessed the association between TWA and ST-segment depression during exercise-induced ambulatory ischemia. Of 351 consecutive patients with coronary artery disease who underwent assessment of microvolt TWA by exercise, 23 patients with effort angina without a history of infarction with ST depression (> or =0.11 mV) during TWA test were selected. These patients were compared with 222 postinfarction patients consisting of 38 patients with, and 184 patients, without the ST depression, and 18 normal individuals. The incidence (9%) of determinate TWA in the patients with angina was significantly (P < .0001) lower than that (52%) in the postinfarction patients. There was no significant difference between the angina patients and the controls (6%). There was also no difference between the patients with (58%) and without the ST depression (51%) in the postinfarction patients. Moreover, no correlation existed between the TWA voltage and the ST-depression magnitude in both angina and postinfarction patients. We concluded that there is no association between TWA and ambulatory ischemia with ST depression. 相似文献
90.
Shoichiro Sumi MD Dr. Kazutomo Inoue MD Masafumi Kogire MD Ryuichiro Doi MD Mitsutoshi Yun MD Hiromu Kaji MD Ryo Hosotani MD Masaki Fujimura MD Kotaro Uchida MD Shinya Kiyama PhD Kouki Kitagawa PhD Haruaki Yajima PhD Nobutaka Fujii PhD Takayoshi Tobe MD 《Digestive diseases and sciences》1991,36(11):1523-1528
This study examined the effect of synthetic porcine neuropeptide Y on the splanchnic blood flows and the exocrine pancreatic secretion in dogs. Graded doses of neuropeptide Y (0.1–5 g/kg, intravenous) caused dose-dependent reduction of the secretin-stimulated exocrine pancreatic secretion and of the blood flows in the superior mesenteric artery, the portal vein, and the pancreatic tissue. Neuropeptide Y at 5 g/kg reduced the blood flows to 45.9±13.3% (superior mesenteric artery), 63.0±10.5% (portal vein), and 77.9±4.8% (pancreatic tissue), respectively. This dose also reduced secretin-stimulated pancreatic juice volume and CCK-8 plus secretin-stimulated protein output to 65.2±9.3 and 63.3±14.0%, respectively. This study shows a potent vasoconstrictor effect of neuropeptide Y on splanchnic vessels. Neuropeptide Y also inhibited exocrine pancreatic secretion in a significant correlation with the reduction in pancreatic tissue blood flow, which suggests that reduction in the blood flow may be one of the possible mechanisms of the inhibitory action of neuropeptide Y on exocrine secretion.This work was supported by a grant from the Ministry of Education, Japan (A-61440060). 相似文献