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131.
Rout Jyoti R. Sahoo Santi L. Das Ritarani Ram Shidharth S. Chakraborty Anindita Sudarshan Mathummal 《Proceedings of the National Academy of Sciences, India. Section B.》2017,87(4):1469-1478
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - The effects of Cu stress on the alterations in the activities of antioxidant enzymes from both leaf and root... 相似文献
132.
Permanent nonselective His bundle pacing in an adult with L‐transposition of the great arteries and complete AV block
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Adam C. Kean MD MPH W. Aaron Kay MD Jyoti K. Patel MD John M. Miller MD Gopi Dandamudi MD 《Pacing and clinical electrophysiology : PACE》2017,40(11):1313-1317
We report the placement of a permanent transvenous nonselective His bundle pacing lead in conjunction with a transvenous pacemaker/implantable cardioverter‐defibrillator in an adult with Levo‐Transposition of the Great Arteries (L‐TGA) and a stenotic coronary sinus (CS) ostium, which would not accommodate a transvenous left ventricular (LV) pacing lead. Nonselective His bundle pacing provided a nearly identical ventricular activation pattern in this previously unpaced patient. Many L‐TGA patients will have an eventual need for permanent pacing and, given the challenges of CS cannulation, His bundle pacing may represent a preferred modality rather than pure morphologic LV pacing or surgical systemic ventricular lead placement to achieve optimal electrical synchrony. 相似文献
133.
Khuda-Bukhsh AR Pathak S Guha B Karmakar SR Das JK Banerjee P Biswas SJ Mukherjee P Bhattacharjee N Choudhury SC Banerjee A Bhadra S Mallick P Chakrabarti J Mandal B 《Evidence-based complementary and alternative medicine : eCAM》2005,2(4):537-548
Groundwater arsenic (As) has affected millions of people globally distributed over 20 countries. In parts of West Bengal (India) and Bangladesh alone, over 100 million people are at risk, but supply of As-free water is grossly inadequate. Attempts to remove As by using orthodox medicines have mostly been unsuccessful. A potentized homeopathic remedy, Arsenicum Album-30, was administered to a group of As affected people and thereafter the As contents in their urine and blood were periodically determined. The activities of various toxicity marker enzymes and compounds in the blood, namely aspartate amino transferase, alanine amino transferase, acid phosphatase, alkaline phosphatase, lipid peroxidation and reduced glutathione, were also periodically monitored up to 3 months. The results are highly encouraging and suggest that the drug can alleviate As poisoning in humans. 相似文献
134.
Nikita M. Virdiya Jayant N. Palaskar Jyoti Wankhade Nikhil Joshi 《The Journal of prosthetic dentistry》2017,117(5):592-596
Aging is associated with loss of teeth, resorption of the alveolar process, and reduced tonicity of the facial muscles, leading to sunken cheeks and an unesthetic appearance. Esthetics in patients in need of complete dentures can be improved with the help of cheek plumpers to support the cheeks. They are noninvasive and straightforward to fabricate. Despite the reported success with the sole use of maxillary cheek plumpers, in certain situations, maxillary cheek plumpers provide inadequate support to the cheeks, evident in the lower third of the face. This clinical report describes a technique for fabricating detachable mandibular and maxillary cheek plumpers with 2 different types of attachment mechanisms. 相似文献
135.
Harish Chandra Pal Ronald D. Baxter Katherine M. Hunt Jyoti Agarwal Craig A. Elmets Mohammad Athar Farrukh Afaq 《Oncotarget》2015,6(29):28296-28311
Melanoma is the most deadly form of cutaneous malignancy, and its incidence rates are rising worldwide. In melanoma, constitutive activation of the BRAF/MEK/ERK (MAPK) and PI3K/AKT/mTOR (PI3K) signaling pathways plays a pivotal role in cell proliferation, survival and tumorigenesis. A combination of compounds that lead to an optimal blockade of these critical signaling pathways may provide an effective strategy for prevention and treatment of melanoma. The phytochemical fisetin is known to possess anti-proliferative and pro-apoptotic activities. We found that fisetin treatment inhibited PI3K signaling pathway in melanoma cells. Therefore, we investigated the effect of fisetin and sorafenib (an RAF inhibitor) alone and in combination on cell proliferation, apoptosis and tumor growth. Combination treatment (fisetin + sorafenib) more effectively reduced the growth of BRAF-mutated human melanoma cells at lower doses when compared to individual agents. In addition, combination treatment resulted in enhanced (i) apoptosis, (ii) cleavage of caspase-3 and PARP, (iii) expression of Bax and Bak, (iv) inhibition of Bcl2 and Mcl-1, and (v) inhibition of expression of PI3K, phosphorylation of MEK1/2, ERK1/2, AKT and mTOR. In athymic nude mice subcutaneously implanted with melanoma cells (A375 and SK-MEL-28), we found that combination therapy resulted in greater reduction of tumor growth when compared to individual agents. Furthermore, combination therapy was more effective than monotherapy in: (i) inhibition of proliferation and angiogenesis, (ii) induction of apoptosis, and (iii) inhibition of the MAPK and PI3K pathways in xenograft tumors. These data suggest that simultaneous inhibition of both these signaling pathways using combination of fisetin and sorafenib may serve as a therapeutic option for the management of melanoma. 相似文献
136.
Mucormycosis is an acute often fatal infection caused by fungi of family mucoracea (Kauffman and Malani Curr Infect Dis Rep 9(6):435–440). The principal pathogens in this family are rhizopus, mucor and absidia species. Mucoracea are found in soil, decaying vegetation and other organic matter. Mucormycosis is a polymorphic disease with diverse clinical manifestation. It is divided into rhinocerebral, pulmonary, cutaneous, cardiac, gastrointestinal and disseminated. Rhinocerebral mucormycosis the most commonest manifestation of mucormycosis is usually a fatal fulminant infection. Rhinocerebral mucormycosis can be further divided into rhino-maxillary and rhino-orbito-cerebral. The disease commonly occur in diabetics who have ketoacidosis but is also seen in severely debilitated or immunosuppressed patients. It has also been reported from otherwise normal individuals. Early diagnosis and treatment is mandatory for a successful management of this infection. 相似文献
137.
ObjectiveTo evaluate the gastric anti-ulcer activity of methanolic extract of Cayratia trifolia L. (MECT) (Vitaceae) leaves in experimental animals.MethodsMECT was investigated in pylorus ligation and ethanol induced ulcer models in Wistar rats. In both models, the common parameter determined was ulcer index. MECT at doses of 250, 500 mg/kg (p.o.) was used to determine whether it could produce significant inhibition of the gastric lesions induced by pylorus ligation and ethanol.ResultsThe extract (250 and 500 mg/kg) showed significant (P<0.05) reduction in gastric volume and ulcer index as compared to the control in both of the two models.ConclusionsIt can be concluded that MECT possesses antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity. 相似文献
138.
Bilateral temporal lobe hyperintensity (BTH) is a commonly encountered MRI finding in a wide spectrum of clinical conditions and often poses a diagnostic challenge to the radiologist. The purpose of this paper is to elucidate several diseases that manifest as BTH on MRI, based on a retrospective review of cranial MRI of 65 cases seen in our institution between October 2007 and September 2010. We found BTH in different clinical scenarios that included infective diseases (herpes simplex virus, congenital cytomegalovirus infection), epileptic syndrome (mesial temporal sclerosis), neurodegenerative disorders (Alzheimer's disease, frontotemporal dementia, Type 1 myotonic dystrophy), neoplastic conditions (gliomatosis cerebri), metabolic disorders (mitochondrial encephalopathy, lactic acidosis and stroke-like episodes, Wilson's disease, hyperammonemia), dysmyelinating disease (megalencephalic leukoencephalopathy with subcortical cysts), and vascular (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) and paraneoplastic (limbic encephalitis) disorders. The conventional MRI findings with advanced MRI such as diffusion-weighted imaging, susceptibility-weighted imaging and MR spectroscopy along with laboratory results are potentially helpful in distinguishing the different clinical conditions and thus affect the early diagnosis and clinical outcome. 相似文献
139.
J Khadka VK Gothwal C McAlinden EL Lamoureux K Pesudovs 《Health and quality of life outcomes》2012,10(1):80
ABSTRACT: BACKGROUND: A critical component that influences the measurement properties of a patient-reportedoutcome (PRO) instrument is the rating scale. Yet, there is a lack of general consensusregarding optimal rating scale format, including aspects of question structure, the number andthe labels of response categories. This study aims to explore the characteristics of ratingscales that function well and those that do not, and thereby develop guidelines forformulating rating scales. METHODS: Seventeen existing PROs designed to measure vision-related quality of life dimensions weremailed for self-administration, in sets of 10, to patients who were on a waiting list for cataractextraction. These PROs included questions with ratings of difficulty, frequency, severity, and global ratings. Using Rasch analysis, performance of rating scales were assessed byexamining hierarchical ordering (indicating categories are distinct from each other and followa logical transition from lower to higher value), evenness (indicating relative utilization ofcategories), and range (indicating coverage of the attribute by the rating scale). RESULTS: The rating scales with complicated question format, a large number of response categories, orunlabelled categories, tended to be dysfunctional. Rating scales with five or fewer responsecategories tended to be functional. Most of the rating scales measuring difficulty performedwell. The rating scales measuring frequency and severity demonstrated hierarchical orderingbut the categories lacked even utilization. CONCLUSION: Developers of PRO instruments should use a simple question format, fewer (four to five) andlabelled response categories. 相似文献
140.
Jyoti Khadka Vijaya K Gothwal Colm McAlinden Ecosse L Lamoureux Konrad Pesudovs 《Health and quality of life outcomes》2012,10(1):1-13