全文获取类型
收费全文 | 1975篇 |
免费 | 187篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 51篇 |
妇产科学 | 30篇 |
基础医学 | 377篇 |
口腔科学 | 31篇 |
临床医学 | 196篇 |
内科学 | 430篇 |
皮肤病学 | 48篇 |
神经病学 | 224篇 |
特种医学 | 36篇 |
外科学 | 183篇 |
综合类 | 11篇 |
预防医学 | 179篇 |
眼科学 | 19篇 |
药学 | 105篇 |
中国医学 | 2篇 |
肿瘤学 | 226篇 |
出版年
2023年 | 24篇 |
2022年 | 32篇 |
2021年 | 81篇 |
2020年 | 50篇 |
2019年 | 56篇 |
2018年 | 86篇 |
2017年 | 50篇 |
2016年 | 48篇 |
2015年 | 51篇 |
2014年 | 71篇 |
2013年 | 98篇 |
2012年 | 197篇 |
2011年 | 144篇 |
2010年 | 68篇 |
2009年 | 67篇 |
2008年 | 115篇 |
2007年 | 109篇 |
2006年 | 111篇 |
2005年 | 100篇 |
2004年 | 86篇 |
2003年 | 83篇 |
2002年 | 59篇 |
2001年 | 33篇 |
2000年 | 26篇 |
1999年 | 25篇 |
1998年 | 15篇 |
1997年 | 12篇 |
1996年 | 14篇 |
1995年 | 13篇 |
1994年 | 18篇 |
1993年 | 6篇 |
1992年 | 23篇 |
1991年 | 27篇 |
1990年 | 20篇 |
1989年 | 12篇 |
1988年 | 15篇 |
1987年 | 9篇 |
1986年 | 15篇 |
1985年 | 11篇 |
1984年 | 6篇 |
1983年 | 10篇 |
1982年 | 7篇 |
1979年 | 5篇 |
1977年 | 4篇 |
1976年 | 4篇 |
1974年 | 4篇 |
1973年 | 4篇 |
1970年 | 5篇 |
1969年 | 4篇 |
1968年 | 5篇 |
排序方式: 共有2166条查询结果,搜索用时 15 毫秒
31.
Eugen Dhimolea Ricardo de Matos Simoes Dhvanir Kansara Aziz Al’Khafaji Juliette Bouyssou Xiang Weng Shruti Sharma Joseline Raja Pallavi Awate Ryosuke Shirasaki Huihui Tang Brian J. Glassner Zhiyi Liu Dong Gao Jordan Bryan Samantha Bender Jennifer Roth Michal Scheffer Constantine S. Mitsiades 《Cancer cell》2021,39(2):240-256.e11
- Download : Download high-res image (202KB)
- Download : Download full-size image
32.
33.
34.
Erik G. Hayman Akil P. Patel W. Taylor Kimberly Kevin N. Sheth J. Marc Simard 《Neurocritical care》2018,28(3):276-287
We sought to review the role that cerebral edema plays in neurologic outcome following cardiac arrest, to understand whether cerebral edema might be an appropriate therapeutic target for neuroprotection in patients who survive cardiopulmonary resuscitation. Articles indexed in PubMed and written in English. Following cardiac arrest, cerebral edema is a cardinal feature of brain injury and is a powerful prognosticator of neurologic outcome. Like other conditions characterized by cerebral ischemia/reperfusion, neuroprotection after cardiac arrest has proven to be difficult to achieve. Neuroprotection after cardiac arrest generally has focused on protecting neurons, not the microvascular endothelium or blood–brain barrier. Limited preclinical data suggest that strategies to reduce cerebral edema may improve neurologic outcome. Ongoing research will be necessary to determine whether targeting cerebral edema will improve patient outcomes after cardiac arrest. 相似文献
35.
36.
Anne-Laure Pin Fran?ois Houle Ma?va Guillonneau éric R. Paquet Martin J. Simard Jacques Huot 《Angiogenesis》2012,15(4):593-608
Endothelial cell migration induced in response to vascular endothelial growth factor (VEGF) is a crucial step of angiogenesis and it depends on the activation of the p38 MAP-kinase pathway downstream of VEGFR2. In this study, we investigated the role of microRNAs (miRNAs) in regulating these processes. We found that the VEGF-induced p38 activation and cell migration are modulated by overexpression of Argonaute 2, a key protein in the functioning of miRNAs. Thereafter, we found that miR-20a expression is increased by VEGF and that its ectopic expression inhibits VEGF-induced actin remodeling and cell migration. Moreover, the expression of miR-20a impairs the formation of branched capillaries in a tissue-engineered model of angiogenesis. In addition, the lentivirus-mediated expression of miR-20a precursor (pmiR-20a) is associated with a decrease in the VEGF-induced activation of p38. In contrast, these processes are increased by inhibiting miR-20a with a specific antagomir. Interestingly, miR-20a does not modulate VEGFR2 or p38 protein expression level. miR-20a does not affect either the expression of other known actors of the p38 MAP kinase pathway except MKK3. Indeed, by using quantitative PCR and Western Blot analysis, we found that pmiR-20a decreases the expression of MKK3 and we obtained evidence indicating that miR-20a specifically binds to the 3′UTR region of MKK3 mRNA. In accordance, the VEGF-induced activation of p38 and cell migration are impaired when the MKK3 expression is knocked down by siRNA. We conclude that miR-20a acts in a feedback loop to repress the expression of MKK3 and to negatively regulate the p38 pathway-mediated VEGF-induced endothelial cell migration and angiogenesis. 相似文献
37.
38.
39.
40.