慢性心力衰竭病人的临床分析

慢性心力衰竭（CHF）目前是老年人住院和死亡的主要原因，近几年研究结果显示CHF病人出现的肾功能障碍即心肾综合征发病率高，预后差，狭义的心肾综合征特指CHF引起的进行性肾功能损害，并导致肾功能不全，我们回顾性分析我院收治的100例CHF住院病人，着重探讨CHF程度与肾功能不全的发生率及其与住院的时间的关系。现将其临床分析介绍如下。     

Colposcopic assessment in microinvasive carcinoma of the cervix

Forty of the 87 patients with microinvasive carcinoma (MIC) of the uterine cervix who underwent surgery were diagnosed colposcopically and the results were compared with the cytological and histological diagnoses. The cytology showed preinvasive carcinoma in 20 (50.0%) patients and invasive carcinoma in 19 (47.5%) patients. A correct colposcopic diagnosis was made in nine (22.5%) patients as having microinvasive carcinoma, 21 (52.5%) patients preinvasive carcinoma and eight (20%) patients invasive carcinoma, to sum up accuracy rate as 32.1%. The abnormalities most commonly observed in colposcopy were mosaic, punctuation and white epithelium. In microinvasive carcinoma, the triad co-existed in 43% of the patients. Atypical vessels, characteristic of invasion, were found in only one third of the patients. Microinvasion, therefore, may not be evident on colposcopy alone. It is therefore necessary to apply cone biopsy, prior to definite therapy, to make an accurate assessment of the maximum depth and extent of the invasion prior to definitive therapy.     

Gene expression and structure of immunoglobulin epsilon chains

The study of immunoglobulin genes has been an active area of research in recent years. The study of IgE heavy (epsilon) chain gene, in particular, has a significant impact on our understanding of the IgE system. The localization of the epsilon gene in the cluster of mouse heavy chain constant region genes has been determined, and models for gene rearrangements leading to epsilon chain gene expression have been provided. The regulation of IgE antibody production can thus be discussed in the context of these models in combination with knowledge of the cellular basis of IgE production. Comparison of the epsilon chain sequence among human, rat, and mouse has allowed a better understanding of the evolution and structure-function relationship of the epsilon chain. Furthermore, expression of epsilon chain cDNA in Escherichia coli and demonstration of biological activities of expression products have paved the basis for identification of defined peptides representing the structures for recognition by IgE receptors. These studies are discussed in this review.     

A novel DRB1*09 allelic sequence in the Jing ethnic minority of China.

A new DRB1 allele, DRB1*0902, has been identified in an individual of the Jing ethnic minority. Its sequence was confirmed by sequencing of PCR products and clones. This allele differed by three nucleotides from DRB1*09012 at positions 157, 161 and 166, and resulted in amino acid motif substitution from VAES to DAEY.     

善宁治疗顽固性大咯血疗效观察

目的 评价善宁对顽固性大咯血的疗效。方法 将55例传统药物抢救无效或有禁忌的大咯血分为治疗组（善宁）与对照组（立止血组），观察24—72h的止血效果。结果 治疗组总有效率为92％，对照组为70％，两组比较有显著差异p〈0．05（x^2=4．125）。结论 善宁治疗大咯血疗效显著，使用安全，不良反应少，值得临床推广应用。     

In vivo actions of insulin-like growth factor-I (IGF-I) on bone formation and resorption in rats

The in vivo action of insulin-like growth factor-I on bone metabolism has been studied using a new model. Insulin-like growth factor-I (IGF-I) was continuously infused into the arterial supply of the right hindlimb of ambulatory rats for up to 14 days and the effects on cortical and trabecular bone formation and the number of osteoclasts were determined by histomorphometric techniques. The contralateral limb acted as an internal control. IGF-I infusion significantly increased cortical bone formation (p less than 0.01). Trabecular bone was increased 22% (p = 0.07), but the infusion was only for seven days. These effects of IGF-I were age dependent, being absent in young, rapidly growing animals, but present at least until one year of age. IGF-I appears to be a purely anabolic hormone for bone formation, since it significantly stimulates osteoblasts and decreases the number of osteoclasts. Thus, although IGF-I mediates the growth-promoting effect of growth hormone, it does not mediate growth hormone's action on bone resorption.