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101.
Novel vascular endothelial growth factor blocker improves cellular viability and reduces hypobaric hypoxia‐induced vascular leakage and oedema in rat brain 下载免费PDF全文
Deepika Saraswat Sarita Nehra Kamal Chaudhary Siva Prasad CVS 《Clinical and experimental pharmacology & physiology》2015,42(5):475-484
Vascular endothelial growth factor (VEGF) is an important cerebral angiogenic and permeability factor under hypoxia. There is a need to find effective molecules that may ameliorate hypoxia‐induced cerebral oedema. In silico identification of novel candidate molecules that block VEGF‐A site were identified and validated with a Ramachandran plot. The active site residues of VEGF‐A were detected by Pocketfinder, CASTp, and DogSiteScorer. Based on in silico data, three VEGF‐A blocker (VAB) candidate molecules (VAB1, VAB2, and VAB3) were checked for improvement in cellular viability and regulation of VEGF levels in N2a cells under hypoxia (0.5% O2). Additionally, the best candidate molecule's efficacy was assessed in male Sprague‐Dawley rats for its ameliorative effect on cerebral oedema and vascular leakage under hypobaric hypoxia 7260 m. All experimental results were compared with the commercially available VEGF blocker sunitinib. Vascular endothelial growth factor‐A blocker 1 was found most effective in increasing cellular viability and maintaining normal VEGF levels under hypoxia (0.5% oxygen) in N2a cells. Vascular endothelial growth factor‐A blocker 1 effectively restored VEGF levels, decreased cerebral oedema, and reduced vascular leakage under hypobaric hypoxia when compared to sunitinib‐treated rats. Vascular endothelial growth factor‐A blocker 1 may be a promising candidate molecule for ameliorating hypobaric hypoxia‐induced vasogenic oedema by regulating VEGF levels. 相似文献
102.
Sankar Prasad Bag Prabir Garu Jim-Long Her Bih-Show Lou Tung-Ming Pan 《RSC advances》2018,8(38):21210
In this paper, we developed a high-performance solid-state pH sensor using a Ce0.9Sr0.1(Zr0.53Ti0.47)O4 (CSZT) membrane through a very simple sol–gel spin-coating process. The structural properties of the CSZT membrane are correlated with its sensing characteristics. The CSZT based EIS sensor exhibited a high pH sensitivity of 92.48 mV pH−1, which is beyond the Nernst limit (59.4 mV pH−1), and good reliability in terms of a low hysteresis voltage of 1 mV and a small drift rate of 0.15 mV h−1. This behaviour is attributed to the incorporation of Sr in the CSZT sensing membrane, which promotes change in the Ce oxidation state from Ce4+ to Ce3+.We developed a high-performance solid-state pH sensor using a Ce0.9Sr0.1(Zr0.53Ti0.47)O4 (CSZT) membrane through a very simple sol–gel spin-coating process. 相似文献
103.
104.
105.
Magnesium transport in normal and uremic patients 总被引:1,自引:0,他引:1
106.
Sudden death in hypertrophic cardiomyopathy: potential importance of altered autonomic control of vasculature 下载免费PDF全文
Current evidence suggests that alterations in the autonomic function and abnormal vascular control play a significant role either as independent triggers themselves or as modifiers of ischaemia and tolerance to to arrhythmias. A combination of several factors--that is, arrhythmia, hypotension, altered autonomic function including vascular control, and ischaemia are therefore likely to act as triggers for sudden death. The relative contribution of each of these factors needs further detailed study. 相似文献
107.
Dr. M. Leela Prasad M.D. Don R. Read M.D. Herand Abcarian M.D. 《Diseases of the colon and rectum》1981,24(6):456-461
Anorectal suppurations are quite common. Supralevator abscesses, previously regarded as a rare subgroup, were seen in 9.1
per cent of 506 patients admitted to Cook County Hospital in a two-year period. Aggressive supportive management was followed
by early, adequate drainage through single or multiple radial perianal incisions or through the rectum whenever indicated.
When fistulas were identified, either a primary fistulotomy or a two-stage fistulotomy using a seton was performed in the
majority of cases. Important factors in the prevention of morbidity and mortality included debridement of all necrotic tissue,
careful bacteriologic studies and judicious use of antibiotics, close postoperative observation, and long-term follow-up of
the patients.
Read at the meeting of the American Society of Colon and Rectal Surgeons, Hollywood, Florida, May 11 to 16, 1980. 相似文献
108.
Perianal abscesses and fistulas 总被引:2,自引:0,他引:2
Paravasthu S. Ramanujam M.D. M. Leela Prasad M.D. Dr. Herand Abcarian M.D. Ana B. Tan R.N. E.T. 《Diseases of the colon and rectum》1984,27(9):593-597
In a five and one-half year period, 1023 patients with anorectal abscesses and fistulas were treated. Under regional anesthesia
the abscesses were unroofed and debrided and a primary fistulotomy was performed whenever a low fistula was identified. In
355 (34.7 per cent) an internal fistulous opening was demonstrated at the time of abscess drainage. Thirty-two patients had
suprashincteric fistulas and underwent two-stage fistulotomy using a seton. Perianal abscesses were encountered in 42.7 per
cent of the patients, followed by ischiorectal (22.7 per cent), intersphincteric (21.4 per cent), and supralevator (7.33 per
cent). The patients with supralevator and intersphincteric abscesses had a high incidence of fistula identified during abscess
drainage. The recurrence rates were 3.7 per cent in the group with abscess drainage only and 1.8 per cent in the group that
had primary fistulotomy along with abscess drainage. The follow-up period averaged 36 months. To accomplish adequate drainage
and identify the deeper components and associated fistulous opening (34.7 per cent of the entire group), careful examination
under regional anesthesia is recommended. Early aggressive treatment of an anorectal abscess and fistula significantly reduces
the possibility of recurrent abscesses and/or the need for further surgery.
Read at the meeting of The American Society of Colon and Rectal Surgeons, Boston, Massachusetts, June 5 to 9, 1983.
Recipient of the 1983 Rowell Laboratories Education Committee Award. 相似文献
109.
110.
Over the years, lipids of non-pathogenic yeast such as Saccharomyces cerevisiae have been characterized to some details; however, a comparable situation does not exist for the human pathogenic fungi. This review is an attempt to bring in recent advances made in lipid research by employing high throughput lipidomic methods in terms of lipid analysis of pathogenic yeasts. Several pathogenic fungi exhibit multidrug resistance (MDR) which they acquire during the course of a treatment. Among the several causal factors, lipids by far have emerged as one of the critical contributors in the MDR acquisition in human pathogenic Candida. In this article, we have particularly focused on the role of lipids involved in cross talks between different cellular circuits that impact the acquisition of MDR in Candida. 相似文献