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61.
冠心病患者血脂异常与胰岛素抵抗的关系 总被引:12,自引:5,他引:7
目的 :探讨冠心病患者血脂异常与胰岛素抵抗的关系。方法 :观察 68例冠心病患者与 66例对照者的血脂、血糖、胰岛素等生化指标 ,以胰岛素释放指数———空腹胰岛素 (FIns) /空腹血糖 (FBG)和胰岛素敏感指数(1 /FBG×FIns)作为胰岛素抵抗 (IR)的指标 ,与空腹血脂进行直线相关分析。结果 :冠心病组与对照组对比 ,血糖水平无明显差异 (P >0 .0 5) ,而血胰岛素、胰岛素释放指数明显较对照组增高 (P <0 .0 5) ,胰岛素敏感指数明显较对照组低 (P <0 .0 5)。冠心病组的甘油三酯 (TG)、总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL -C)明显较对照组增高 (P <0 .0 5)、高密度脂蛋白胆固醇 (HDL -C)明显较对照组低 (P <0 .0 5)。冠心病组胰岛素释放指数、胰岛素敏感指数分别与TG ,TC和LDL -C呈正相关 ,与HDL -C呈负相关。结论 :冠心病患者存在着高胰岛素血症和胰岛素抵抗 ,而且冠心病患者的胰岛素抵抗和血脂异常密切相关。 相似文献
62.
应用免疫磁珠法分离脐血CD34^+细胞,以比较CD34^+细胞亚群及各系相关抗原的变化。经过分离,CD34^+细胞由1.47±0.77%升至57.39±16.17%,分离后CD34^+CD38^-细胞占CD34^+细胞的比率为7.82±4.79%CD34^+。细胞纯化同时可减少CD3^+细胞达14.12±9.18倍,CD15^+细胞减少16.42±21.47倍;B系(CD19)、巨核系(CD41) 相似文献
63.
抗—HCV阳性单采浆供血员HGV感染随访研究 总被引:3,自引:0,他引:3
为了解单采浆供血员庚型肝炎病毒(HGV)感染及其转归,对102名抗-HCV阳性单采浆供血员冻存血清进行抗-HGV和HGVRNA检测,对抗-HGV和(或)HGVRNA阳性者作3年随访研究。采用EIA法检测抗-HGV,包被抗原来自HGV不同功能区的合成肽。应用RT-PCR法检测HGVRNA,引物选自HGVNS3区。结果表明,抗-HCV阳性单采浆供血员HGVRNA阳性率为19.61%(20/102),抗-HGV阳性率为17.65%(18/102),HGV感染率(抗HGV和/或HGVRNA阳性)为24.51%(25/102),而对照组仅为0.94%(1/106)。提示单采血浆是HGV感染的重要危险因素。HGVRNA和抗-HGV的3年阴转率分别为35.00%(7/20)和11.11%(2/18),说明HGV感染有慢性携带趋势 相似文献
64.
Dr. James Hui Ph.D. Dr. Yow-Ming C. Wang Ph.D. Dr. Appavu Chandrasekaran Ph.D. Dr. Douglas R. Geraets Pharm.D. Dr. James H. Caldwell M.D. Dr. Larry W. Robertson Ph.D. Dr. Richard H. Reuning Ph.D. 《Pharmacotherapy》1994,14(5):607-612
Study Objective . To compare digoxin tablets and liquid-filled capsules with respect to excretion of the drug and its metabolites in urine and feces at steady state. Design . A randomized, crossover trial, each period lasting 3 weeks, with no washout period. Setting . A university hospital. Patients . Six patients, five of whom were elderly, with histories of gastrointestinal disorders, such as hypochlorhydria, intestinal bacterial overgrowth, and inflammatory bowel disease. Interventions . The patients received digoxin once/day in either tablet or capsule form for 3 weeks, and then were switched to the other formulation. Total urinary and fecal excretion from the last 3 days of each regimen were analyzed for the drug and metabolites. Measurements and Main Results . No statistically significant differences were found between tablets and capsules in recovery of digoxin or its metabolites in urine or feces (p=0.05). One subject had a 4-fold increase in urinary drug excretion and 50% decrease in fecal excretion after taking the capsules compared with tablets. Intersubject variability in extent and type of metabolite excretion was greater than intrasubject variability. Conclusions . Fecal analyses may be an accurate way to classify patients as formers of digoxin reduction products. 相似文献
65.
66.
Objective. To study the characteristics of changes of LDH enzyme patterns of mice under slight hypoxia.Methods. Mice treated with artificial hypoxia, various tissues were made for the test of LDH enzymatic activity by the specific staining technique. LDH (1 -5) relative percentage enzymatic activity (RPEA) were measured with CS-910 dual-wavelength thin layer chromatography scanner.Results. The RPEA of LDH isozymes of various tissues after slight hypoxia shifted to the isozymes LDH1 and LDH2, whose principal subunits are H subunits, and the RPEA of LDH,(H4), LDH2(H3M) increased, while RPEA of LDH5(M4) in various tissues decreased prominently except the cardiac muscle, and that of LDH4(HM3) decreased as well. After polyacrylamide gel electrophoresis (PAGE) of the hypoxia treated cardiac muscle specimen was made, activity subbands originated regularly in the isozyme patterns of LDH, with the regularity of LDH1 (0 subband), LDH2 (0-1 subbands), LDH3 (0-2 subbands), LDH4 (1-3 subbands), LDH5 (2-4 subbands). 相似文献
67.
Hsiu Hui Chiu Hsiao Hui Chou Wen Dar Jean Wung Yang Shieh 《Journal of microbiology, immunology, and infection》2007,40(1):14-23
BACKGROUND AND PURPOSE: Marine luminous bacteria were isolated and identified from samples in shallow coastal waters of Taiwan during the relatively warm seasons. METHODS: Identification of the luminous isolates was performed based on differences of phenotypic and genotypic characteristics together with data from phylogenetic analysis. RESULTS: Twenty seven strains of marine luminous bacteria were isolated. They were divided into five types based on differences of phenotypic characteristics. However, they could be clustered into only two genotypes according to the analysis of restriction patterns of polymerase chain reaction-amplified 16S rRNA genes digested with various restriction enzymes. The characterization data together with the 16S rRNA gene-based phylogenetic analysis revealed that the isolates included in phenotype I (seven isolates) could be Photobacterium leiognathi, and those included in phenotypes II-V (twenty isolates) might be classified as Vibrio harveyi. However, phylogeny based on gyrB sequences indicated that phenotypes II-V could be classified into two species, V. harveyi and Vibrio campbellii. CONCLUSION: Culturable luminous bacteria in the shallow coastal waters of Taiwan during the sampling period are dominated by V. harveyi/campbellii and P. leiognathi, and the former species appeared to be more prevalent and numerous than the latter species in general. 相似文献
68.
云南金铁锁的生物学特性及其保护的初步研究 总被引:12,自引:0,他引:12
对金铁锁的生物学特征、适应性及其机理进行探讨。结果表明:金铁锁具有旱生植物的结构和特征,耐旱、耐贫瘠能力较细。同时提出了相应的保护措施。为合理的开发、利用和保护金铁锁提供了依据。 相似文献
69.
目的 了解本社区高血压患者的危险因素现状,探讨干预对策。方法 采用分层整群抽样的方法,随机抽取社区4个里委2级、3级高血压患者402例作为研究对象,收集各项危险因素如性别、年龄、血脂、血糖、吸烟、饮食、体育锻炼、体重等,并进行统计分析。结果402例高血压患者1年内进行所有相关辅助检查者有14例,占3.48%;1年内进行相关辅助检查一项者306例,占76.12%。饮食控制及进行体育锻炼有300例,占74.43%;吸烟62例,占15.42%。结论 高血压患者对饮食控制及体育锻炼、吸烟有害的知晓率明显提高,而对相关辅助检查认识不足。 相似文献
70.